Patents by Inventor Julie Anne Lim

Julie Anne Lim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 6-Alkoxy-pyrido-pyrimidines
    Patent number: 7320987
    Abstract: The present invention provides compounds of the Formula I: wherein R1 is alkyl, cycloalkyl, cycloalkylalkyl, or —CH2-alkenyl, X1 is O, NH, N(alkyl), S or —C(?O), Z is N or CH; and R2 and R3 are as defined herein, pharmaceutical compositions comprising same, and methods for their use.
    Type: Grant
    Filed: March 21, 2007
    Date of Patent: January 22, 2008
    Assignee: Roche Palo Alto LLC
    Inventors: David Michael Goldstein, Julie Anne Lim
  • 6-alkoxy-pyrido-pyrimidines
    Patent number: 7196097
    Abstract: The present invention provides compounds of the Formula I: wherein R1 is alkyl, cycloalkyl, cycloallkylalkyl, or —CH2-alkenyl, X1 is O, NH, N(alkyl), S or —C(?O), Z is N or CH; and R2 and R3 are as defined herein, pharmaceutical compositions comprising same, and methods for their use.
    Type: Grant
    Filed: August 14, 2006
    Date of Patent: March 27, 2007
    Assignee: Roche Palo Alto LLC
    Inventors: David Michael Goldstein, Julie Anne Lim
  • 6-alkoxy-pyrido-pyrimidines
    Patent number: 7105525
    Abstract: The present invention provides compounds of the Formula I: wherein R1 is alkyl, cycloalkyl, cycloalkylalkyl, or —CH2-alkenyl, X1 is O, NH, N(alkyl), S or —C(?O), Z is N or CH; and R2 and R3are as defined herein, pharmaceutical compositions comprising same, and methods for their use.
    Type: Grant
    Filed: May 4, 2005
    Date of Patent: September 12, 2006
    Assignee: Roche Palo Alto LLC
    Inventors: David Michael Goldstein, Julie Anne Lim
  • 6-alkoxy-pyrido-pyridine
    Patent number: 6965030
    Abstract: The present invention provides compounds of the Formula I: wherein R1 is alkyl, cycloalkyl, cycloalkylalkyl, or —CH2-alkenyl, X1 is O, NH, N(alkyl), S or —C(?O), Z is N or CH; and R2 and R3 are as defined herein, pharmaceutical compositions comprising same, and methods for their use.
    Type: Grant
    Filed: August 5, 2003
    Date of Patent: November 15, 2005
    Assignee: Roche Palo Alto LLC
    Inventors: David Michael Goldstein, Julie Anne Lim
  • Methods of treating p38 kinase-mediated disorders with pyrido[2,3-d]pyrimidin-7-one compounds
    Patent number: 6861423
    Abstract: Disorders mediated by p38 kinase inhibitors are treated with compounds of the formula: or salts thereof, wherein: R1 is hydrogen or alkyl; R2 is substituted cycloalkyl, heterosubstituted cycloalkyl, helcroalkylsubstituted cycloalkyl, heterosubstituted cycloalkyl-alkly, heterocyclyl, heterocyclyl spiro cycloalkyl, aralkoxy, alkoxy, -alkylene-S(O)n-alkyl (where is 1 or 2) or —SO2Ar2; R3 is hydrogen, amino, monoalkylamino, dialkylamino, acylamino, —NR8—C(?O)—Rb (where Ra is hydrogen or alkyl and Rh is heterocyclyl or heteroalkyl), alkyl, cycloalkyl, phthalimidoalkyl, aryl, aralkyl, haloalkyl, heteroalkyl, cyanoalkyl, -alkylene-C(O) R (where R is hydrogen, alkyl, hydroxy, alkoxy, amino, monoalkylamino or dialkylamino) or acyl; and each of Ar1 and Ar2 is independently aryl.
    Type: Grant
    Filed: August 29, 2002
    Date of Patent: March 1, 2005
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Jian Jeffrey Chen, James Patrick Dunn, David Michael Goldstein, Julie Anne Lim
  • 7-oxo-pyridopyrimidines (II)
    Publication number: 20040192709
    Abstract: The present invention provides compounds of the formula: 1
    Type: Application
    Filed: April 1, 2004
    Publication date: September 30, 2004
    Applicant: Syntex (U.S.A.) LLC
    Inventors: Humberto Bartolome Arzeno, Jian Jeffrey Chen, James Patrick Dunn, David Michael Goldstein, Julie Anne Lim
  • 7-oxo-pyridopyrimidines (II)
    Patent number: 6753427
    Abstract: The present invention provides compounds of the formula: a prodrug or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and Ar1 are those defined herein, and methods for preparation and uses thereof.
    Type: Grant
    Filed: December 10, 2002
    Date of Patent: June 22, 2004
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Humberto Bartolome Arzeno, Jian Jeffrey Chen, James Patrick Dunn, David Michael Goldstein, Julie Anne Lim
  • 6-alkoxy-pyrido-pyrimidines
    Publication number: 20040038999
    Abstract: The present invention provides compounds of the Formula I: 1
    Type: Application
    Filed: August 5, 2003
    Publication date: February 26, 2004
    Inventors: David Michael Goldstein, Julie Anne Lim
  • 7-oxo-pyridopyrimidines (I)
    Publication number: 20030153586
    Abstract: The present invention provides compounds of the formula: 1
    Type: Application
    Filed: August 29, 2002
    Publication date: August 14, 2003
    Applicant: Syntex (U.S.A) LLC
    Inventors: Jian Jeffrey Chen, James Patrick Dunn, David Michael Goldstein, Julie Anne Lim
  • 7-oxo-pyridopyrimidines (II)
    Publication number: 20030144307
    Abstract: The present invention provides compounds of the formula: 1
    Type: Application
    Filed: December 10, 2002
    Publication date: July 31, 2003
    Inventors: Humberto Bartolome Arzeno, Jian Jeffrey Chen, James Patrick Dunn, David Michael Goldstein, Julie Anne Lim
  • 7-oxo-pyridopyrimidines (II)
    Patent number: 6518276
    Abstract: The present invention provides compounds of the formula: wherein R1, R3, and Ar1 are those defined herein, and R2 is —CR′R″—Ra (where R′ and R″ are hydrogen, hydroxyalkyl or alkyl with at least one being alkyl or hydroxyalkyl and Ra is hydroxyalkyl), Rx—S—Ry— (where Rx is alkyl and Ry is alkylene), alkoxy-substituted alkyl, heterocyclylalkyl or C4-C5 cycloalkyl, wherein each of the hydroxy group present in R2 can be independently Ra—C(═O)—O, RaRbN—C(═O)—O, or Ra—S(O)2—O—, wherein Ra and Rb are independently hydrogen, alkyl, aryl, or aralkyl, and methods for preparation and uses thereof.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: February 11, 2003
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Humberto Bartolome Arzeno, Jian Jeffrey Chen, James Patrick Dunn, David Michael Goldstein, Julie Anne Lim
  • 7-oxo-pyridopyrimidines (I)
    Patent number: 6506749
    Abstract: The present invention provides compounds of the formula: wherein R2 is substituted cycloalkyl, heterosubstituted cycloalkyl, heteroalkylsubstituted cycloalkyl, heterosubstituted cycloalkyl-alkyl, optionally substituted heterocyclyl, spiro-substituted cycloalkyl, aralkoxy, alkoxy, -alkylene-S(O)n-alkyl (wherein n is 1 or 2), or —SO2Ar2; and R1, R3, and Ar1 are those defined herein, and methods for preparation and uses thereof.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: January 14, 2003
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Jian Jeffrey Chen, James Patrick Dunn, David Michael Goldstein, Julie Anne Lim
  • 7-oxo-pyridopyrimidines (I)
    Publication number: 20020137756
    Abstract: The present invention provides compounds of the formula: 1
    Type: Application
    Filed: August 30, 2001
    Publication date: September 26, 2002
    Inventors: Jian Jeffrey Chen, James Patrick Dunn, David Michael Goldstein, Julie Anne Lim
  • 7-oxo-pyridopyrimidines (II)
    Publication number: 20020055513
    Abstract: The present invention provides compounds of the formula: 1
    Type: Application
    Filed: August 30, 2001
    Publication date: May 9, 2002
    Inventors: Humberto Bartolome Arzeno, Jian Jeffrey Chen, James Patrick Dunn, David Michael Goldstein, Julie Anne Lim