Abstract: The present invention provides a method for detecting an analyte in a sample and a device for carrying out the method. The method comprises the following steps. (i) Providing a mixture comprising a sample, a reporter reagent, and a pre-activator reagent to a device, the device comprising a substrate having an optical component and a binding component, where the optical component and the binding component are attached to a surface of the substrate, the reporter reagent being capable of generating reactive oxygen species from the pre-activator reagent upon absorption of electromagnetic radiation, and the optical component being capable of changing from a first optical state to a second optical state on reaction with the reactive oxygen species. (ii) Allowing a portion of the reporter reagent to bind to the surface of the substrate in proportion to the concentration of the analyte, by means of the binding component.

Abstract: Described herein are methods of processing heat treatable aluminum alloys using an accelerated aging step, along with aluminum alloy products prepared according to the methods. The methods of processing the heat treatable alloys described herein provide a more efficient method for producing aluminum alloy products having the desired strength and formability properties. For example, conventional methods of processing alloys can require 24 hours of aging. The methods described herein, however, substantially reduce the aging time, often requiring eight hours or less of aging time.

Abstract: Systems and methods are described for roll-forming metal substrates. The metal substrates are subjected to induction heating during the roll-forming process by exposure to time-varying magnetic fields, such as by exposure to a rotating permanent magnet, or exposure to laser radiation from a laser source. Heating of the metal substrates allows improved formability or plasticity of the substrate in order to reduce or eliminate damage to the substrate during roll-forming to low bending radius to thickness ratios. Heating of the high-strength metal substrates can also function to temper the substrates and/or improve surface corrosion resistance and form high-strength end products with desirable properties.

Abstract: Described are processes for shaping age hardenable aluminum alloys, such as 2XXX, 6XXX and 7XXX aluminum alloys in T4 temper, or articles made of such alloys, including aluminum alloy sheets. The processes involve heating the sheet or article before and/or concurrently with a forming step. In some examples, the sheet is heated to a specified temperature in the range of about 100-600° C. at a specified heating rate within the range of about 3-600° C./s, for example about 3-90° C./s. Such a combination of temperature and heating rate results in an advantageous combination of sheet properties.

Abstract: The present invention provides a method for detecting an analyte in a sample, the method comprising the steps of: a method for detecting an analyte in a sample, the method comprising the steps of: (i) providing a mixture comprising a sample and a reporter reagent to a device, the device comprising a substrate having an optical component and a binding component attached to a surface of the substrate; (ii) allowing a proportion of the reporter reagent to bind to the surface of the substrate in proportion to the concentration of the analyte, by means of the binding component; (ill) irradiating the device with electromagnetic radiation for absorption by a photosensitiser of the reporter reagent, such that the photosensitiser of the bound reporter reagent portion interacts with the optical component to cause the optical component to change from a first optical state to a second optical state, thereby forming a set of local regions of the optical component having the second optical state on the substrate; and (iv)

Abstract: Described are processes for shaping a hardened heat treatable, age-hardenable aluminum alloys, such as hardened 2XXX, 6XXX and 7XXX aluminum alloys, or articles made from such alloys, including aluminum alloy sheets. The processes involve heating the article, which may be in a form of a sheet or a blank, before and/or concurrently with a forming step. In some examples, the alloy is heated to a specified temperature in the range of 125-425° C. at a specified heating rate within the range of about 3-200° C./s, for example, 3-90° C./s or 90-150° C./s. Such a combination of the temperature and the heating rate can result in an advantageous combination of article properties.

Abstract: Described herein are methods of processing heat treatable aluminum alloys using an accelerated aging step, along with aluminum alloy products prepared according to the methods. The methods of processing the heat treatable alloys described herein provide a more efficient method for producing aluminum alloy products having the desired strength and formability properties. For example, conventional methods of processing alloys can require 24 hours of aging. The methods described herein, however, substantially reduce the aging time, often requiring eight hours or less of aging time.

Abstract: Described are processes for shaping a hardened heat treatable, age-hardenable aluminum alloys, such as hardened 2XXX, 6XXX and 7XXX aluminum alloys, or articles made from such alloys, including aluminum alloy sheets. The processes involve heating the article, which may be in a form of a sheet or a blank, before and/or concurrently with a forming step. In some examples, the alloy is heated to a specified temperature in the range of 125-425° C. at a specified heating rate within the range of about 3-200° C./s, for example, 3-90° C./s or 90-150° C./s. Such a combination of the temperature and the heating rate can result in an advantageous combination of article properties.

Abstract: Processes for improving the strength of heat-treatable, age hardenable aluminum alloys, such as 6xxx, 2xxx and 7xxx aluminum alloys, are provided. The processes for improving the strength of heat-treatable, age-hardenable aluminum alloys involve a heat treatment step, termed “shock heat treatment,” which involves heat treatment at 200 to 350° C. that is conducted at a fast heating rate (for example 10 to 220° C./seconds) for a relatively short period of time (for example, for 60 seconds or less or for 5 to 30 seconds). In some examples, the shock heat treatment is accomplished by contact heating, such as heating an aluminum alloy article between complementary shaped heated dies of a press. Aluminum alloy articles, such as automotive panels, produced by the disclosed shock heat treatment are also provided.

Abstract: Described are processes for shaping a hardened heat treatable, age-hardenable aluminum alloys, such as hardened 2XXX, 6XXX and 7XXX aluminum alloys, or articles made from such alloys, including aluminum alloy sheets. The processes involve heating the article, which may be in a form of a sheet or a blank, before and/or concurrently with a forming step. In some examples, the alloy is heated to a specified temperature in the range of 125-425° C. at a specified heating rate within the range of about 3-200° C./s, for example, 3-90° C./s or 90-150° C./s. Such a combination of the temperature and the heating rate can result in an advantageous combination of article properties.

Abstract: Processes for improving the strength of heat-treatable, age hardenable aluminum alloys, such as 6xxx, 2xxx and 7xxx aluminum alloys, are provided. The processes for improving the strength of heat-treatable, age-hardenable aluminum alloys involve a heat treatment step, termed “shock heat treatment,” which involves heat treatment at 200 to 350° C. that is conducted at a fast heating rate (for example 10 to 220° C./seconds) for a relatively short period of time (for example, for 60 seconds or less or for 5 to 30 seconds). In some examples, the shock heat treatment is accomplished by contact heating, such as heating an aluminum alloy article between complementary shaped heated dies of a press. Aluminum alloy articles, such as automotive panels, produced by the disclosed shock heat treatment are also provided.

Abstract: This invention provides a method for detecting an analyte in a sample using electromagnetic radiation comprising: (i) providing a labelled reagent, the labelled reagent having a binding site which is capable of binding the analyte or an analogue of the analyte and a label, wherein the label is capable of absorbing the electromagnetic radiation to generate energy by non-radiative decay; (ii) providing a device having a radiation source adapted to generate a series of pulses of electromagnetic radiation, a transducer having a pyroelectric or piezoelectric element and electrodes, which is capable of transducing energy generated by non-radiative decay into an electrical signal, a detector which is capable of detecting the electrical signal, a controller for controlling the source of electromagnetic radiation and the detector, wherein the device has a first and second chamber, the first chamber containing a first reagent proximal to the transducer, wherein the first reagent is capable of binding to the analyte suc

Abstract: This invention relates to a device for detecting an analyte in a sample comprising: a radiation source adapted to generate a series of pulses of electromagnetic radiation; a transducer having a pyroelectric or piezoelectric element and electrodes which is capable of transducing energy generated by non-radiative decay into an electrical signal; a detector which is capable of detecting the electrical signal generated by the transducer; a first reagent proximal to the transducer, the first reagent having a binding site which is capable of binding a labelled reagent proportionally to the concentration of the analyte in the sample, which labelled reagent being capable of absorbing the electromagnetic radiation generated by the radiation source to generate energy by non-radiative decay; a second reagent proximal to the transducer, the second reagent having a lower affinity for the labelled reagent under the conditions of the assay than the first reagent; and a third reagent proximal to the transducer, the third rea

Abstract: Described are processes for shaping age hardenable aluminum alloys, such as 2XXX, 6XXX and 7XXX aluminum alloys in T4 temper, or articles made of such alloys, including aluminum alloy sheets. The processes involve heating the sheet or article before and/or concurrently with a forming step. In some examples, the sheet is heated to a specified temperature in the range of about 100-600° C. at a specified heating rate within the range of about 3-600° C./s, for example about 3-90° C./s. Such a combination of temperature and heating rate results in an advantageous combination of sheet properties.

Abstract: Described are processes for shaping a hardened heat treatable, age-hardenable aluminum alloys, such as hardened 2XXX, 6XXX and 7XXX aluminum alloys, or articles made from such alloys, including aluminum alloy sheets. The processes involve heating the article, which may be in a form of a sheet or a blank, before and/or concurrently with a forming step. In some examples, the alloy is heated to a specified temperature in the range of 125-425° C. at a specified heating rate within the range of about 3-200° C./s, for example, 3-90° C./s or 90-150° C./s. Such a combination of the temperature and the heating rate can result in an advantageous combination of article properties.

Abstract: Processes for improving the strength of heat-treatable, age hardenable aluminum alloys, such as 6xxx, 2xxx and 7xxx aluminum alloys, are provided. The processes for improving the strength of heat-treatable, age-hardenable aluminum alloys involve a heat treatment step, termed “shock heat treatment,” which involves heat treatment at 200 to 350° C. that is conducted at a fast heating rate (for example 10 to 220° C./seconds) for a relatively short period of time (for example, for 60 seconds or less or for 5 to 30 seconds). In some examples, the shock heat treatment is accomplished by contact heating, such as heating an aluminum alloy article between complementary shaped heated dies of a press. Aluminum alloy articles, such as automotive panels, produced by the disclosed shock heat treatment are also provided.

Abstract: This invention relates to a device for detecting an analyte in a sample comprising: a radiation source adapted to generate a series of pulses of electromagnetic radiation; a transducer having a pyroelectric or piezoelectric element and electrodes which is capable of transducing energy generated by non-radiative decay into an electrical signal; a detector which is capable of detecting the electrical signal generated by the transducer; a first reagent proximal to the transducer, the first reagent having a binding site which is capable of binding a labelled reagent proportionally to the concentration of the analyte in the sample, which labelled reagent being capable of absorbing the electromagnetic radiation generated by the radiation source to generate energy by non-radiative decay; a second reagent proximal to the transducer, the second reagent having a lower affinity for the labelled reagent under the conditions of the assay than the first reagent; and a third reagent proximal to the transducer, the third rea

Abstract: This invention relates to an assay label comprising an amorphous carbon particle, a functionalised dextran polymer attached to the surface of the carbon particle and a first member of a complementary binding pair covalently bonded to the functionalised dextran polymer. The invention also provides a device incorporating the assay label, which further comprises a radiation source adapted to generate a series of pulses of electromagnetic radiation at a wavelength such that the absorption of the radiation by the label generates energy by non-radiative decay; a sample chamber containing a transducer having a pyroelectric or piezoelectric element and electrodes which is capable of transducing energy generated by non-radiative decay into an electrical signal; and a detector which is capable of detecting the electrical signal generated by the transducer.

Abstract: This invention relates to a device for detecting an analyte in a sample comprising: a radiation source adapted to generate a series of pulses of electromagnetic radiation; a transducer having a pyroelectric or piezoelectric element and electrodes which is capable of transducing energy generated by non-radiative decay into an electrical signal; a detector which is capable of detecting the electrical signal generated by the transducer; a first reagent proximal to the transducer, the first reagent having a binding site which is capable of binding a labelled reagent proportionally to the concentration of the analyte in the sample, which labelled reagent being capable of absorbing the electromagnetic radiation generated by the radiation source to generate energy by non-radiative decay; a second reagent proximal to the transducer, the second reagent having a lower affinity for the labelled reagent under the conditions of the assay than the first reagent; and a third reagent proximal to the transducer, the third rea

Abstract: The present invention relates to a polypeptide monobody which includes a modified acid sequence and renders the polypeptide monobody able to bind selectively to ???3 integrin. Fusion proteins and conjugates which include the polypeptide monobody, as well as compositions containing the polypeptide monobody, fusion proteins, or conjugates are also disclosed. Uses thereof include: treating or preventing an ???3 integrin-mediated disease or disorder, inhibiting ???3 integrin activity, treating a cancerous or precancerous condition, imaging tissues using positron emission tomography or magnetic resonance imaging, assessing the metastatic characteristics of a tumor, and delivering DNA to a cell.