Patents by Inventor Julie S. Biteen

Julie S. Biteen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Three-dimensional single-molecule fluorescence imaging beyond the diffraction limit using a double-helix point spread function
    Patent number: 9881355
    Abstract: Embodiments of the present invention can resolve molecules beyond the optical diffraction limit in three dimensions. A double-helix point spread function can be used to in conjunction with a microscope to provide dual-lobed images of a molecule. Based on the rotation of the dual-lobed image, the axial position of the molecule can be estimated or determined. In some embodiments, the angular rotation of the dual-lobed imaged can be determined using a centroid fit calculation or by finding the midpoints of the centers of the two lobes. Regardless of the technique, the correspondence between the rotation and axial position can be utilized. A double-helix point spread function can also be used to determine the lateral positions of molecules and hence their three-dimensional location.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: January 30, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO
    Inventors: Rafael Piestun, Sri Rama Prasanna Pavani, Michael A. Thompson, Julie S. Biteen, William E. Moerner
  • THREE-DIMENSIONAL SINGLE-MOLECULE FLUORESCENCE IMAGING BEYOND THE DIFFRACTION LIMIT USING A DOUBLE-HELIX POINT SPREAD FUNCTION
    Publication number: 20140226881
    Abstract: Embodiments of the present invention can resolve molecules beyond the optical diffraction limit in three dimensions. A double-helix point spread function can be used to in conjunction with a microscope to provide dual-lobed images of a molecule. Based on the rotation of the dual-lobed image, the axial position of the molecule can be estimated or determined. In some embodiments, the angular rotation of the dual-lobed imaged can be determined using a centroid fit calculation or by finding the midpoints of the centers of the two lobes. Regardless of the technique, the correspondence between the rotation and axial position can be utilized. A double-helix point spread function can also be used to determine the lateral positions of molecules and hence their three-dimensional location.
    Type: Application
    Filed: February 12, 2014
    Publication date: August 14, 2014
    Applicants: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, THE REGENTS OF THE UNIVERSITY OF COLORADO
    Inventors: Rafael Piestun, Sri Rama Prasanna Pavani, Michael A. Thompson, Julie S. Biteen, William E. Moerner
  • Three-dimensional single-molecule fluorescence imaging beyond the diffraction limit using a double-helix point spread function
    Patent number: 8693742
    Abstract: Embodiments of the present invention can resolve molecules beyond the optical diffraction limit in three dimensions. A double-helix point spread function can be used to in conjunction with a microscope to provide dual-lobed images of a molecule. Based on the rotation of the dual-lobed image, the axial position of the molecule can be estimated or determined. In some embodiments, the angular rotation of the dual-lobed imaged can be determined using a centroid fit calculation or by finding the midpoints of the centers of the two lobes. Regardless of the technique, the correspondence between the rotation and axial position can be utilized. A double-helix point spread function can also be used to determine the lateral positions of molecules and hence their three-dimensional location.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: April 8, 2014
    Assignee: The Regents of the University of Colorado
    Inventors: Rafael Piestun, Sri Rama Prasanna Pavani, Michael A. Thompson, Julie S. Biteen, William E. Moerner
  • THREE-DIMENSIONAL SINGLE-MOLECULE FLUORESCENCE IMAGING BEYOND THE DIFFRACTION LIMIT USING A DOUBLE-HELIX POINT SPREAD FUNCTION
    Publication number: 20100278400
    Abstract: Embodiments of the present invention can resolve molecules beyond the optical diffraction limit in three dimensions. A double-helix point spread function can be used to in conjunction with a microscope to provide dual-lobed images of a molecule. Based on the rotation of the dual-lobed image, the axial position of the molecule can be estimated or determined. In some embodiments, the angular rotation of the dual-lobed imaged can be determined using a centroid fit calculation or by finding the midpoints of the centers of the two lobes. Regardless of the technique, the correspondence between the rotation and axial position can be utilized. A double-helix point spread function can also be used to determine the lateral positions of molecules and hence their three-dimensional location.
    Type: Application
    Filed: December 17, 2009
    Publication date: November 4, 2010
    Applicants: The Regents of the University of Colorado, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Rafael Piestun, Sri Rama Prasanna Pavani, Michael A. Thompson, Julie S. Biteen, William E. Moerner