Patents by Inventor Julie Spielman

Julie Spielman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODIFIED HEAT SHOCK PROTEIN-ANTIGENIC PEPTIDE COMPLEX
    Publication number: 20140335086
    Abstract: The present invention relates to methods for purifying immunogenic, prophylactically and therapeutically effective complexes of modified heat shock proteins noncovalently associated with antigenic peptides of cancer or infected cells. The claimed methods comprise the constructing of a nucleotide sequence encoding a secretable modified heat shock protein, expressing the sequence in an appropriate host cell, recovering the immunogenic complexes from the cell culture and the cells, and purifying the immunogenic complexes by affinity chromatography. Large amounts of such immunogenic complexes can be obtained by large-scale culturing of host cells containing the genetic sequence. The complexes can be used as a vaccine to elicit specific immune responses against cancer or infected cells, and to treat or prevent cancer or infectious diseases.
    Type: Application
    Filed: February 11, 2014
    Publication date: November 13, 2014
    Applicant: University of Miami
    Inventors: Eckhard R. Podack, Julie Spielman, Koichi Yamazaki
  • Recombinant cancer cell secreting modified heat shock protein-antigenic peptide complex
    Patent number: 8685384
    Abstract: The present invention relates to methods for purifying immunogenic, prophylactically and therapeutically effective complexes of modified heat shock proteins noncovalently associated with antigenic peptides of cancer or infected cells. The claimed methods comprise the constructing of a nucleotide sequence encoding a secretable modified heat shock protein, expressing the sequence in an appropriate host cell, recovering the immunogenic complexes from the cell culture and the cells, and purifying the immunogenic complexes by affinity chromatography. Large amounts of such immunogenic complexes can be obtained by large-scale culturing of host cells containing the genetic sequence. The complexes can be used as a vaccine to elicit specific immune responses against cancer or infected cells, and to treat or prevent cancer or infectious diseases.
    Type: Grant
    Filed: July 24, 2007
    Date of Patent: April 1, 2014
    Assignee: University of Miami
    Inventors: Eckhard R. Podack, Julie Spielman, Koichi Yamazaki
  • Recombinant cancer cell secreting modified heat shock protein-antigenic peptide complex
    Publication number: 20080026012
    Abstract: The present invention relates to methods for purifying immunogenic, prophylactically and therapeutically effective complexes of modified heat shock proteins noncovalently associated with antigenic peptides of cancer or infected cells. The claimed methods comprise the constructing of a nucleotide sequence encoding a secretable modified heat shock protein, expressing the sequence in an appropriate host cell, recovering the immunogenic complexes from the cell culture and the cells, and purifying the immunogenic complexes by affinity chromatography. Large amounts of such immunogenic complexes can be obtained by large-scale culturing of host cells containing the genetic sequence. The complexes can be used as a vaccine to elicit specific immune responses against cancer or infected cells, and to treat or prevent cancer or infectious diseases.
    Type: Application
    Filed: July 24, 2007
    Publication date: January 31, 2008
    Applicant: The University of Miami
    Inventors: Eckhard Podack, Julie Spielman, Koichi Yamazaki