Abstract: The present invention provides MMLV reverse transcriptase enzymes with increased thermal stability as compared with wild type MMLV and AMV reverse transcriptases. The improved thermal stability allows for reverse transcription of RNA to cDNA at temperatures above 37° C., thereby reducing error rates introduced during cDNA synthesis. As a result, the reverse transcriptases of the invention allow for increased accuracy in the determination of transcriptomes of living organisms.

Abstract: A system comprises a processor, a display, and a memory having computer readable instructions stored thereon that, when executed by the processor, cause the system to receive intra-operative three-dimensional image data from an imaging system. A portion of the intra-operative three-dimensional image data corresponds to an instrument disposed in a patient anatomy. The computer readable instructions, when executed by the processor, further cause the system to generate two-dimensional projection image data from the intra-operative three-dimensional image data, display the two-dimensional projection image data on the display, and identify, within the two-dimensional projection image data, a three-dimensional location of a portion of the instrument.

Abstract: A high-speed watercraft lift for raising and lowering a watercraft relative to a body of water, the lift comprising a cradle configured to support the watercraft, a cable suspending the cradle, a rotatable spindle configured take up the cable, and a submergible rotary motor. The cradle comprises a number of interconnected beams and a number of bunks connected to at least some of the interconnected beams. The cable is liftably linked to at least one of the interconnected beams. The rotatable spindle is configured to coil portions of the cable to raise the cradle and uncoil the portions of the cable to lower the cradle. The submergible rotary motor is configured to rotate the spindle.

Abstract: Systems and methods for providing navigation indicators for an elongate device include a system configured to determine a pose of the elongate device within a passageway; and based on the pose of the elongate device, display on the display system: an image of the passageway, and one or more navigation indicators associated with one or more directions within a workspace containing the passageway, wherein the one or more navigation indicators are displayed over the image of the passageway.

Abstract: A medical system comprises an elongate device, an elongate sheath configured to extend within the elongate device, and an imaging probe configured to extend within the elongate sheath. The elongate sheath includes an identification feature. The medical system further comprises a control system configured to receive imaging data from the imaging probe. The imaging data is captured by the imaging probe. The control system is further configured to analyze the imaging data to identify an appearance of the identification feature within the imaging data. The control system is further configured to, based on the appearance of the identification feature, register the imaging data to a reference frame of the elongate device.

Abstract: The present invention provides methods and compositions that use a polypeptide that includes a methyl-CpG-binding domain to capture and isolate methylated DNA from a sample.

Abstract: The present invention provides MMLV reverse transcriptase enzymes with increased thermal stability as compared with wild type MMLV and AMV reverse transcriptases. The improved thermal stability allows for reverse transcription of RNA to cDNA at temperatures above 37° C., thereby reducing error rates introduced during cDNA synthesis. As a result, the reverse transcriptases of the invention allow for increased accuracy in the determination of transcriptomes of living organisms.

Abstract: Vector haptic feedback cues are provided by combining force cues from two or more 1-D actuators driven with asymmetric vibrations. In order for this combination to work properly, it is important for the actuators being combined to be mechanically isolated from each other. This combination can be a perceptual combination of force cues provided to different locations on the same body part of a user.