Abstract: The present disclosure relates generally to processes for preparing a compound useful in the prevention or treatment of a Retroviridae viral infection, including an infection caused by the human immunodeficiency virus (HIV).

Abstract: The present disclosure provides binding agents, such as antibodies, that specifically bind ILT3, including human ILT3, as well as compositions comprising the binding agents, and methods of their use. The disclosure also provides related polynucleotides and vectors encoding the binding agents and cells comprising the binding agents.

Abstract: The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.

Abstract: Systems, methods, and compositions for generating a high-resolution spatial map of a distribution of targets of a sample are described. Systems and methods can further include features configured to reduce observation of smearing artifacts in generated spatial maps. Processes for generating the spatial map can include: receiving the sample at a substrate having a distribution of functionalized particles, each having a stochastic barcode sequence paired with a position on the substrate; promoting interactions between the distribution of targets of the sample and the distribution of functionalized particles; applying a set of reactions to the sample at the substrate; and obtaining a set of sequences of a population of molecules generated from the set of reactions.

Abstract: This disclosure relates to biodegradable core-shell microcapsule compositions wherein the microcapsule shell contains a polymer formed with a biobased epoxide and a polyamine. This disclosure also relates to a method of preparing such biodegradable core-shell microcapsules. This disclosure also relates to consumer products containing such biodegradable core-shell microcapsules.

Abstract: Antibodies that bind SARS-CoV spike protein, SARS-CoV-2 spike protein, and methods of using same for treating or preventing conditions associated with SARS or COVID-19 and for detecting SARS-CoV or SARS-CoV-2.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: In an example embodiment, a server accesses, for a plurality of customer accounts within a professional networking service, a plurality of features of the customer accounts stored with the professional networking service. The server accesses, for the plurality of customer accounts within the professional networking service, past sales records of products from the professional networking service to the plurality of employer accounts. The server determines, based on the past sales records and based on one or more features from the plurality of features, a product to upsell or cross-sell to a specific customer account. The server provides, as a digital transmission, indicia of the one or more features and the determined product.

Abstract: A method of making a membrane electrode assembly is provided. The method includes providing a non-porous polymeric substrate which has sufficient structural integrity and elastic deformation such that no significant deformations occur during processing to facilitate reuse. The substrate is optionally formed into a loop for continuous processing. A slurry is formed which includes an ionically conductive material, an electrically conductive material, a catalyst, and a high boiling point solvent. The slurry is applied onto the non-porous polymeric substrate, for example, in a pattern of discrete regions. The slurry is dried to form decals. The decals are bonded to a membrane and then the substrate is peeled from the decal in a substantially undamaged condition so that it may be reused.

Abstract: A method for coordinating transaction data for targeted offer generation includes facilitating opt-in to a cardholder offer generation scheme, and facilitating obtaining transaction data associated with a card transaction, via a payment card processing network. The transaction data includes (i) attribute data indicative of an attribute of at least one item purchased, and (ii) an account number of the card. Storage of at least the attribute data in a data warehouse is facilitated, in association with indicia of the holder. The steps can be repeated for a plurality of transactions at a plurality of sales entities, to generate a cross-transaction, cross-entity, actual-product-purchased-based data warehouse profile of the holder. Generating a non-real-time offer to the holder by an operator of the payment card network is facilitated, based, at least in part, on data mining performed on the data warehouse profile.

Abstract: A method of optimizing program code performance is disclosed. Applications written in the Java language can execute slowly. To speed up the execution time of a Java application certain slower executing methods within the application can be written in native code. When the slower executing methods are written in native code some of the advantages, such as automatic garbage collection, of the Java language are lost. Further, the resultant interface function calls between the Java methods and the native methods can result in inefficient code. The method optimizes programs written using both Java methods and native methods, i.e. mixed mode code, by analyzing a set of interface function calls from native methods to a Java Virtual Machine.

Abstract: Compilers are tools that generate efficient mappings from programs to machines A Java “Just In Time” runs as part of an application, and as such, it must be fast and efficient in its use of memory. To achieve good performance and further optimize code generation, the present invention introduces a method for optimizing Java performance using precompiled code. The method of the present invention first monitors the performance of program code during program execution. Then a list of program functions for possible native code compilation is created. The list may be created based upon static and dynamic analysis of the computer program. A plurality of program functions from said list of program functions is selected for optimization and native compilation. The selected program functions are precompiled into native program functions. The present invention also allows the precompiled native code reverted so that a user could explore the performance tuning until satisfactory.