Abstract: The present disclosure is generally directed to the use of compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured or humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a Sortilin protein, e.g., human Sortilin or mammalian Sortilin, and have improved and/or enhanced functional characteristics, in treating and/or delaying progression of a disease or injury in an individual in need thereof.

Abstract: Disclosed are TRPM8 modulators as defined by formula (I) for achieving a cooling effect on skin and mucousa.

Abstract: Disclosed are monoclonal antibodies, antigen binding fragments, and bi-specific antibodies that specifically bind a coronavirus spike protein, such as SARS-CoV-2. Also disclosed is the use of these antibodies for inhibiting a coronavirus infection, such as a SARS-CoV-2 infection. In addition, disclosed are methods for detecting a coronavirus, such as SARS-CoV-2, in a biological sample, using the disclosed antibodies.

Abstract: In some implementations, a classification system may receive credentials associated with a data source and may receive, from the data source and using the credentials, a set of structured data including input events and output events. The classification system may filter the set of structured data by applying a first set of rules to generate a filtered set of structured data and may convert the filtered set of structured data to one or more numerical vectors, where a vector space associated with the one or more numerical vectors is infinite-dimensional. The classification system may further cluster the one or more numerical vectors using a first machine learning model to generate one or more clusters. Accordingly, the classification system may determine one or more classifications based on the set of structured data, each of the one or more classifications being associated with a corresponding frequency and a corresponding category.

Abstract: In an example embodiment, a server accesses, for a plurality of customer accounts within a professional networking service, a plurality of features of the customer accounts stored with the professional networking service. The server accesses, for the plurality of customer accounts within the professional networking service, past sales records of products from the professional networking service to the plurality of employer accounts. The server determines, based on the past sales records and based on one or more features from the plurality of features, a product to upsell or cross-sell to a specific customer account. The server provides, as a digital transmission, indicia of the one or more features and the determined product.

Abstract: A method of making a membrane electrode assembly is provided. The method includes providing a non-porous polymeric substrate which has sufficient structural integrity and elastic deformation such that no significant deformations occur during processing to facilitate reuse. The substrate is optionally formed into a loop for continuous processing. A slurry is formed which includes an ionically conductive material, an electrically conductive material, a catalyst, and a high boiling point solvent. The slurry is applied onto the non-porous polymeric substrate, for example, in a pattern of discrete regions. The slurry is dried to form decals. The decals are bonded to a membrane and then the substrate is peeled from the decal in a substantially undamaged condition so that it may be reused.

Abstract: A method for coordinating transaction data for targeted offer generation includes facilitating opt-in to a cardholder offer generation scheme, and facilitating obtaining transaction data associated with a card transaction, via a payment card processing network. The transaction data includes (i) attribute data indicative of an attribute of at least one item purchased, and (ii) an account number of the card. Storage of at least the attribute data in a data warehouse is facilitated, in association with indicia of the holder. The steps can be repeated for a plurality of transactions at a plurality of sales entities, to generate a cross-transaction, cross-entity, actual-product-purchased-based data warehouse profile of the holder. Generating a non-real-time offer to the holder by an operator of the payment card network is facilitated, based, at least in part, on data mining performed on the data warehouse profile.

Abstract: A method of optimizing program code performance is disclosed. Applications written in the Java language can execute slowly. To speed up the execution time of a Java application certain slower executing methods within the application can be written in native code. When the slower executing methods are written in native code some of the advantages, such as automatic garbage collection, of the Java language are lost. Further, the resultant interface function calls between the Java methods and the native methods can result in inefficient code. The method optimizes programs written using both Java methods and native methods, i.e. mixed mode code, by analyzing a set of interface function calls from native methods to a Java Virtual Machine.

Abstract: Compilers are tools that generate efficient mappings from programs to machines A Java “Just In Time” runs as part of an application, and as such, it must be fast and efficient in its use of memory. To achieve good performance and further optimize code generation, the present invention introduces a method for optimizing Java performance using precompiled code. The method of the present invention first monitors the performance of program code during program execution. Then a list of program functions for possible native code compilation is created. The list may be created based upon static and dynamic analysis of the computer program. A plurality of program functions from said list of program functions is selected for optimization and native compilation. The selected program functions are precompiled into native program functions. The present invention also allows the precompiled native code reverted so that a user could explore the performance tuning until satisfactory.