Abstract: An orthotic compression brace includes a tubular sleeve namely knit from elastic yarns, covering at least the arm and the hand, up to the insertion of phalanges on the metacarpal bones of the hand, and a protrusion aimed to, at least partially, cover the thumb over its entire circumference. The tubular sleeve and the thumb are knit into one piece and the thumb is knit at least in part as from the thermobonding at a T1 temperature the sleeve eventually containing thermobonding yarns at a T2 temperature strictly greater than T1.