Abstract: Implantable capsule comprising a cell receiving portion (2) comprising a porous membrane (5) surrounding a cell receiving chamber (13) for receiving immortalized cells in a liquid media therein for the secretion of therapeutic agents. The capsule further comprises a cell support matrix (7) inserted within the cell receiving chamber (13) configured for the arrangement of the immortalized cells within the cell receiving chamber.

Abstract: The disclosure relates to a retrievable intrauterine device which includes a recess suitable for containing one or more elements selected from the group that includes an embryo, male and/or female gametes, a fertilized oocyte, a non-fertilized ovule and a combination of the elements. The recess includes an inner wall made of a biocompatible polymer, the inner wall including at least one perforated portion having perforations with dimensions of between 1 pm and 10 pm, and an outer wall covering the inner wall, the outer wall being made of a biocompatible silicone elastomer and including at least one opening opposite said at least one perforated portion of the inner wall. The use of the device relates to the preimplantation development of gametes and/or embryos.

Abstract: The invention relates to a retrievable intrauterine device which includes a recess (10) suitable for containing one or more elements selected from the group that includes an embryo, male and/or female gametes, a fertilised oocyte, a non-fertilised ovule and a combination of said elements. The recess (10) includes an inner wall (11) made of a biocompatible polymer, the inner wall (11) including at least one perforated portion (13a, 13b) having perforations with dimensions of between 1 ?m and 10 ?m, and an outer wall (12) covering the inner wall (11), the outer wall (12) being made of a biocompatible silicone elastomer and including at least one opening (14a, 14b) opposite said at least one perforated portion (13a, 13b) of the inner wall (11). The use of the device relates to the pre-implantation development of gametes and/or embryos.