Patents by Inventor Julien HIBLOT

Julien HIBLOT has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CIRCULARLY PERMUTATED HALOALKANE TRANSFERASE FUSION MOLECULES
    Publication number: 20220275350
    Abstract: The invention relates to a modular polypeptide comprising a first partial effector sequence comprising a first part of a circular permutated halotag protein connected to a sensor module sequence, which is connected to a second part of a circular permutated halotag protein. The sensor module is a single polypeptide or a polypeptide pair capable of undergoing conformational change from a first confirmation to a second confirmation depending on the presence or concentration of an analyte compound. The modular peptide is catalytically active in response to an environmental stimulus or in response to the sensor pair interacting. The invention further relates to nucleic acid sequences encoding the modular polypeptide, and to kits comprising same.
    Type: Application
    Filed: April 16, 2020
    Publication date: September 1, 2022
    Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E. V.
    Inventors: Julien HIBLOT, Magnus HUPPERTZ, Kai JOHNSSON, Wilhelm JONAS
  • Vulcanisaetal phosphotriesterase-like lactonases (PLL) having enhanced properties and the uses thereof
    Patent number: 10202587
    Abstract: Provided is a mutated hyperthermophilic PTE having a lactonase activity derived from a hyperthermophilic phosphotriesterase corresponding to the consensus sequence of SEQ ID NO: 1, the mutated PTE including the at least one mutation chosen amongst 55 putative positions and the mutated PTE having enhanced properties. Also provided are compositions including the mutated hyperthermophilic PTE and the uses thereof, notably as bioscavenger of organophosphate compounds or as quorum quencher of the bacteria using lactones to communicate.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: February 12, 2019
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE D'AIX-MARSEILLE
    Inventors: Eric Chabriere, Mikael Elias, Julien Hiblot, Didier Raoult
  • SULFOLOBAL PHOSPHOTRIESTERASE-LIKE (PLL) LACTONASES ACTIVITY HAVING ENHANCED PROPERTIES AND THE USES THEREOF
    Publication number: 20190040369
    Abstract: Mutated hyperthermophilic PTE having a lactonase activity derived from a hyperthermophilic phosphotriesterase corresponding to the consensus sequence of SEQ ID NO: 1, the mutated PTE including the at least one mutation chosen amongst 53 putative positions and the mutated PTE having enhanced properties. Also provided are compositions including the mutated hyperthermophilic PTE and the uses thereof, notably as bioscavenger of organophosphate compounds or as quorum quencher of the bacteria using lactones to communicate.
    Type: Application
    Filed: August 7, 2018
    Publication date: February 7, 2019
    Inventors: Eric Chabriere, Mikael Elias, Julien Hiblot, Didier Raoult
  • Sulfolobal phosphotriesterase-like (PLL) lactonases activity having enhanced properties and the uses thereof
    Patent number: 10072252
    Abstract: Mutated hyperthermophilic PTE having a lactonase activity derived from a hyperthermophilic phosphotriesterase corresponding to the consensus sequence of SEQ ID NO: 1, the mutated PTE including the at least one mutation chosen amongst 53 putative positions and the mutated PTE having enhanced properties. Also provided are compositions including the mutated hyperthermophilic PTE and the uses thereof, notably as bioscavenger of organophosphate compounds or as quorum quencher of the bacteria using lactones to communicate.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: September 11, 2018
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE D'AIX-MARSEILLE
    Inventors: Eric Chabriere, Mikael Elias, Julien Hiblot, Didier Raoult
  • VULCANISAETAL PHOSPHOTRIESTERASE-LIKE LACTONASES (PLL) HAVING ENHANCED PROPERTIES AND THE USES THEREOF
    Publication number: 20160237413
    Abstract: Provided is a mutated hyperthermophilic PTE having a lactonase activity derived from a hyperthermophilic phosphotriesterase corresponding to the consensus sequence of SEQ ID NO: 1, the mutated PTE including the at least one mutation chosen amongst 55 putative positions and the mutated PTE having enhanced properties. Also provided are compositions including the mutated hyperthermophilic PTE and the uses thereof, notably as bioscavenger of organophosphate compounds or as quorum quencher of the bacteria using lactones to communicate.
    Type: Application
    Filed: July 31, 2014
    Publication date: August 18, 2016
    Inventors: Eric CHABRIERE, Mikael ELIAS, Julien HIBLOT, Didier RAOULT
  • SULFOLOBAL PHOSPHOTRIESTERASE-LIKE (PLL) LACTONASES ACTIVITY HAVING ENHANCED PROPERTIES AND THE USES THEREOF
    Publication number: 20160115462
    Abstract: Mutated hyperthermophilic PTE having a lactonase activity derived from a hyperthermophilic phosphotriesterase corresponding to the consensus sequence of SEQ ID NO: 1, the mutated PTE including the at least one mutation chosen amongst 53 putative positions and the mutated PTE having enhanced properties. Also provided are compositions including the mutated hyperthermophilic PTE and the uses thereof, notably as bioscavenger of organophosphate compounds or as quorum quencher of the bacteria using lactones to communicate.
    Type: Application
    Filed: April 14, 2014
    Publication date: April 28, 2016
    Inventors: Eric CHABRIERE, Mikael ELIAS, Julien HIBLOT, Didier RAOULT