Abstract: Method for validating access, by a user, to an access zone and associated electronic validation system The invention relates to a method for validating an access, for a user (10), to an access zone (Z5) of a public transport vehicle (5). The method is implemented by an electronic generation system (15), The method comprises the following successive steps: reception of a request for access (Da) to the access zone, from the connected device (20) in an approval zone, pre-validation of the request for access if the request meets a predetermined condition, and determination of a location of the connected device in the access zone (Z5) distinct from the approval zone. The method further comprising, once the location of the connected device has been determined in the access zone and only if the request for access is pre-validated, a validation step for an access to the access zone for the user, by decrementing an account specific to the user.

Abstract: The invention relates to a method for determining the phase difference between a first clock signal (CK1) received by a first electronic component (CE1) and a second clock signal (CK2) received by a second electronic component (CE2), comprising the steps of: S10) transmitting a first calibration signal (S12); S20) measuring a first delay (T1); S30) transmitting a second calibration signal (S21); S40) measuring a second delay (T2); S50) measuring the number (n) of clock pulses between the transmission of the first calibration signal (S12) and the active edge of the first clock signal (CK1) consecutive to the active edge of the second calibration signal (S21); S60) determining the phase difference depending on the parity of the number (n) of clock pulses.

Abstract: The present disclosure is directed to compounds of Formula (1): wherein m, n, Y, R1, R2, R3, R4 and R5 are each as described herein, as stereoisomers, enantiomers or tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, and pharmaceutical compositions comprising the compounds of Formula (I), as described herein, which are useful as voltage-gated potassium channel modulators and are therefore are useful in treating seizure disorders such as epilepsy.

Abstract: Methods, systems, and devices are described for predicting a destination of a user and sharing the presumed destination with the other users via a geographically-based graphical user interface. Consistent with some embodiments, an electronic communication containing location information is received from a location sensor coupled to a first client device. A current trajectory of the first user is determined based on the location information. A presumed destination of the first user is determined, by correlating the current trajectory of the first user with historical location information of the first user. A map depicting an icon associated with the presumed destination of the first user is displayed, on a display screen of a second client device of a second user.

Abstract: The invention is based on the discovery of a new bacterial compound with analgesic properties which could be used as a new tool for the treatment of pain disorders such as visceral pain. Studying the mechanisms implicated in analgesic properties of the probiotic Escherichia coli strain Nissle 1917 (EcN), inventors characterized, the amino fatty acids produced by EcN, which display the Ecn analgesic properties. One of these compounds inhibits the hypersensitivity to colorectal distension induced by capsaicin, which is a very powerful nociceptive compound and acts via the GABA B receptor. Furthermore, inventors demonstrate that this compound is able to cross the cellular epithelial barrier (such as the intestinal epithelium). Thus, the invention relates to a lipopetide compound, derived from gamma-aminobutyric acid. The invention also relates to a lipopeptide compound according to the invention for the treatment of treating pain disorder, such as somatic pain and visceral pain.

Abstract: Methods, systems, and devices are described for predicting a destination of a user and sharing the presumed destination with the other users via a geographically-based graphical user interface. Consistent with some embodiments, an electronic communication containing location information is received from a location sensor coupled to a first client device. A current trajectory of the first user is determined based on the location information. A presumed destination of the first user is determined, by correlating the current trajectory of the first user with historical location information of the first user. A map depicting an icon associated with the presumed destination of the first user is displayed, on a display screen of a second client device of a second user.

Abstract: A tool, method and system for automatically managing risks including a processor configured to select an input characteristic, called a target characteristic, the contribution of which in the tolerance chain is greater than a predetermined contribution threshold, replace the value of the target characteristic with a test value, determine an output statistical distribution according to each test value, measure the portion of lack of compliance with the tolerances that are associated with the output requirements, evaluate a first indicator of the impact of the risk of lack of compliance with tolerances associated with the output requirements according to each test value, evaluate a second indicator of severity of the risk representing weighting of the first indicator of the impact of the risk with a probability of occurrence of the test value, and define a set of sorting criteria which are graduated on the basis of the first and second indicators.

Abstract: Methods, systems, and devices are described for predicting a destination of a user and sharing the presumed destination with the other users via a geographically-based graphical user interface. Consistent with some embodiments, an electronic communication containing location information is received from a location sensor coupled to a first client device. A current trajectory of the first user is determined based on the location information. A presumed destination of the first user is determined, by correlating the current trajectory of the first user with historical location information of the first user. A map depicting an icon associated with the presumed destination of the first user is displayed, on a display screen of a second client device of a second user.

Abstract: Methods, systems, and devices are described for predicting a destination of a user and sharing the presumed destination with the other users via a geographically-based graphical user interface. Consistent with some embodiments, an electronic communication containing location information is received from a location sensor coupled to a first client device. A current trajectory of the first user is determined based on the location information. A presumed destination of the first user is determined, by correlating the current trajectory of the first user with historical location information of the first user. A map depicting an icon associated with the presumed destination of the first user is displayed, on a display screen of a second client device of a second user.