Patents by Inventor Juliette K. Busse

Juliette K. Busse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors
    Publication number: 20030023092
    Abstract: Methods for the preparation of chemical intermediates in the synthesis of HIV-protease inhibitors related to and including nelfinavir mesylate are disclosed. The method of this invention comprises converting tetrohydran derivatives into oxazolines to provide key reaction intermediates for the preparation of nelfinavir. Also disclosed is a method for the preparation of a chiral amino alcohol from an epoxy-tetrahydrofuran.
    Type: Application
    Filed: August 26, 2002
    Publication date: January 30, 2003
    Inventors: Bennett C. Borer, Scott E. Zook, Juliette K. Busse
  • Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors
    Patent number: 6472534
    Abstract: Methods for the preparation of chemical intermediates in the synthesis of HIV-protease inhibitors related to and including nelfinavir mesylate are disclosed. The method of this invention comprises converting tetrohydran derivatives into oxazolines to provide key reaction intermediates for the preparation of nelfinavir. Also disclosed is a method for the preparation of a chiral amino alcohol from an epoxy-tetrahydrofuran.
    Type: Grant
    Filed: November 7, 2001
    Date of Patent: October 29, 2002
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Bennett C. Borer, Scott E. Zook, Juliette K. Busse
  • Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors
    Patent number: 6465661
    Abstract: HIV protease inhibitors inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds can be prepared by the novel methods of the present invention using the novel inventive intermediates.
    Type: Grant
    Filed: March 21, 2002
    Date of Patent: October 15, 2002
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Srinivasan Babu, Bennett C. Borer, Travis P. Remarchuk, Robert J. Szendroi, Kathleen R. Whitten, Juliette K. Busse, Kim F. Albizati
  • Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors
    Patent number: 6403799
    Abstract: Methods for the preparation of chemical intermediates in the synthesis of HIV-protease inhibitors related to and including nelfinavir mesylate are disclosed. The method of this invention comprises converting tetrohydran derivatives into oxazolines to provide key reaction intermediates for the preparation of nelfinavir. Also disclosed is a method for the preparation of a chiral amino alcohol from an epoxy-tetrahydrofuran.
    Type: Grant
    Filed: October 17, 2000
    Date of Patent: June 11, 2002
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Bennett C. Borer, Scott E. Zook, Juliette K. Busse
  • Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors
    Patent number: 6392067
    Abstract: HIV protease inhibitors inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds can be prepared by the novel methods of the present invention using the novel inventive intermediates.
    Type: Grant
    Filed: May 21, 2001
    Date of Patent: May 21, 2002
    Assignees: Agouron Pharmaceuticals, Inc., Japan Tobacco Inc.
    Inventors: Srinivasan Babu, Bennett C. Borer, Travis P. Remarchuk, Robert J. Szendroi, Kathleen R. Whitten, Juliette K. Busse, Kim F. Albizati
  • Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors
    Publication number: 20020038033
    Abstract: Methods for the preparation of chemical intermediates in the synthesis of HIV-protease inhibitors related to and including nelfinavir mesylate are disclosed. The method of this invention comprises converting tetrohydran derivatives into oxazolines to provide key reaction intermediates for the preparation of nelfinavir. Also disclosed is a method for the preparation of a chiral amino alcohol from an epoxy-tetrahydrofuran.
    Type: Application
    Filed: November 7, 2001
    Publication date: March 28, 2002
    Inventors: Bennett C. Borer, Scott E. Zook, Juliette K. Busse
  • Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors
    Patent number: 6316625
    Abstract: HIV protease inhibitors inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds can be prepared by the novel methods of the present invention using the novel inventive intermediates.
    Type: Grant
    Filed: July 21, 2000
    Date of Patent: November 13, 2001
    Assignees: Agouron Pharmaceuticals, Inc., Japan Tobacco Inc.
    Inventors: Srinivasan Babu, Bennett C. Borer, Travis P. Remarchuk, Robert J. Szendroi, Kathleen R. Whitten, Juliette K. Busse, Kim F. Albizati
  • Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors
    Patent number: 6117999
    Abstract: HIV protease inhibitors inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds can be prepared by the novel methods of the present invention using the novel inventive intermediates.
    Type: Grant
    Filed: February 19, 1999
    Date of Patent: September 12, 2000
    Assignees: Agouron Phramaceuticals, Inc., Japan Tobacco, Inc.
    Inventors: Srinivasan Babu, Bennett C. Borer, Travis P. Remarchuk, Robert J. Szendroi, Kathleen R. Whitten, Juliette K. Busse, Kim F. Albizati
  • Intermediates for making HIV-protease inhibitors
    Patent number: 6084107
    Abstract: HIV protease inhibitors inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds can be prepared by the novel methods of the present invention using the novel inventive intermediates.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: July 4, 2000
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Srinivasan Babu, Bennett C. Borer, Travis P. Remarchuk, Robert J. Szendroi, Kathleen R. Whitten, Juliette K. Busse, Kim F. Albizati
  • Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors
    Patent number: 5925759
    Abstract: HIV protease inhibitors inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds can be prepared by the novel methods of the present invention using the novel inventive intermediates.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: July 20, 1999
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Srinivasan Babu, Bennett C. Borer, Travis P. Remarchuk, Robert J. Szendroi, Kathleen R. Whitten, Juliette K. Busse, Kim F. Albizati
  • Process for preparation of N-demethyl-4"-deoxy-erthromycins A and B
    Patent number: 5922849
    Abstract: A process for the preparation of N-demethyl-4"-deoxy-erythromycins A and B, having the formula: ##STR1## wherein R.sup.a is H or OH, by stepwise addition of iodine and base to the N-dimethyl-4"-deoxyerythromycin, preferably, accompanied by sparging with an inert gas.
    Type: Grant
    Filed: November 22, 1996
    Date of Patent: July 13, 1999
    Assignee: Abbott Laboratories
    Inventors: Ramiya H. Premchandran, Albert V. Thomas, Juliette K. Busse, John E. Dete
  • Intermediates for making HIV-protease inhibitors
    Patent number: 5705647
    Abstract: HIV protease inhibitors inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds can be prepared by the novel methods of the present invention using the novel inventive intermediates.
    Type: Grant
    Filed: September 5, 1996
    Date of Patent: January 6, 1998
    Assignees: Agouron Pharmaceuticals, Inc., Japan Tobacco, Inc.
    Inventors: Srinivasan Babu, Bennett C. Borer, Travis P. Remarchuk, Robert J. Szendroi, Kathleen R. Whitten, Juliette K. Busse, Kim F. Albizati
  • Process for the preparation of N-4-[(substituted phenyl)alkylheterocyclic]- N
    Patent number: 5580989
    Abstract: A process for preparing a compound of the structure I ##STR1## where A is oxygen and sulfur and R.sup.1 is selected from the group consisting of hydrogen, halogen, alkyl of one to six carbon atoms, alkoxy of one to six carbon atoms, and trifluoromethyl, and R.sup.2 is alkyl of one to four carbon atoms, comprising coupling a compound of formula II: ##STR2## where X is bromine or iodine, with an N-hydroxyurea compound of formula III: ##STR3## in the presence of a palladium catalyst followed by reaction of the product thus formed with an alkali metal isocyante.The compounds of formula I are inhibitors of the enzyme 5-lipoxygenase and are thus useful as therapeutic agents for the treatment of allergic and inflammatory disease conditions.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 3, 1996
    Assignee: Abbott Laboratories
    Inventors: James D. Ratajczyk, Juliette K. Busse, Sanjay R. Chemburkar, Daniel A. Dickman, Yi-Yin Ku, Hemantkumar H. Patel, Ramesh R. Patel, David P. Sawick, John N. Starr, Bhadra Shelat, Harry O. Spiwek