Patents by Inventor Julio A. Aguirre

Julio A. Aguirre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210121527
    Abstract: Disclosed herein are methods of treating minimal residual cancer in a subject. The methods involve contacting disseminated cancer cells (DCCs) in a subject with a bone morphogenic protein 7 (BMP7) derivative protein, where the contacting induces or maintains dormancy in the contacted DCCs of the subject to treat minimal residual cancer in the subject. Also disclosed are methods that involve contacting DCCs in a subject with a protein kinase RNA-like endoplasmic reticulum kinase (PERK) inhibitor selected from LY2, LY3, and LY4, where said contacting eradicates DCCs in the subject to treat minimal residual cancer in the subject.
    Type: Application
    Filed: March 26, 2019
    Publication date: April 29, 2021
    Inventor: Julio A. AGUIRRE-GHISO
  • Patent number: 8689565
    Abstract: A combined cycle power generation plant can include at least one gas turbine and at least one steam turbine. A method for providing Asymmetric Joint Control for Primary Frequency Regulation (PFR) in the combined cycle power generation plant can include the use of the spinning energy existing in the high pressure steam to rapidly supply additional power to the steam turbine for PFR service within the time frame established as a requirement to participate in the PFR service. The PFR control method can be carried out by controlling flow of high pressure steam to a medium pressure steam circuit through a bypass.
    Type: Grant
    Filed: December 22, 2008
    Date of Patent: April 8, 2014
    Assignee: Petrobras Energia S.A.
    Inventors: Benjamin Guzman, Jorge Vugdelija, Julio Aguirre
  • Publication number: 20120142634
    Abstract: The disclosure provides methods for treating or preventing a cancerous condition, such as multiple myeloma, by administering a therapeutically effective combination of a proteasome inhibitor and salubrinal.
    Type: Application
    Filed: November 10, 2009
    Publication date: June 7, 2012
    Applicant: MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY
    Inventors: Denis M. Schewe, Julio A. Aguirre-Ghiso
  • Publication number: 20100249184
    Abstract: The present invention relates to a method of inducing cancer cells into dormancy and treating cancer in a subject. This method involves administering to a subject an effective amount of a compound that disrupts interaction between urokinase plasminogen activator receptor and integrin, thereby including cancer cells into dormancy and treating cancer in the subject. Also disclosed is a method of disrupting interaction between integrin and urokinase plasminogen activator receptor on cancer cells. The present invention also relates to a method of screening for compounds effective in inducing tumor dormancy and treating cancer in a subject.
    Type: Application
    Filed: March 17, 2008
    Publication date: September 30, 2010
    Applicants: MOUNT SINAI SCHOOL OF MEDICINE, COPENHAGEN HOSPITAL CORPORATION
    Inventors: Liliana Ossowski, Pratima Chaurasia, Julio A. Aguirre-Ghiso, Ming-Ming Zhou, Michael Ploug
  • Publication number: 20090277183
    Abstract: A method for providing Asymmetric Joint Control for Primary Frequency Regulation (PFR) in combined cycle power generation plants, said plant comprising at least one gas turbine and at least one steam turbine is provided. The method may comprise the use of the spinning energy existing in the high pressure steam to rapidly supply additional power to the steam turbine for PFR service when required by the grid, within the time frame established as a requirement to participate in the PFR service,. In some embodiments, PFR control can be carried out jointly in the whole combined cycle plant and the distribution of spinning reserve energy can be asymmetric.
    Type: Application
    Filed: December 22, 2008
    Publication date: November 12, 2009
    Applicant: PETROBRAS ENERGIA S.A.
    Inventors: Benjamin Guzman, Jorge Vugdelija, Julio Aguirre
  • Patent number: 4739990
    Abstract: A self-defense/attack device comprises a rigid, tubular body having a blunt tip at one end that is adapted to deliver lethal/non-lethal blows to the chest or other regions of a human body. Joined to the tubular body at a substantially right angle to the longitudinal axis of the body and closer to the end opposite the blunt tip is a rigid projection shorter in length and smaller in circumference than the body itself. The projection terminates in a rounded blunt tip that can also deliver lethal/non-lethal blows to an attacker.
    Type: Grant
    Filed: April 7, 1986
    Date of Patent: April 26, 1988
    Inventors: Julio A. Aguirre, Armand G. Winfield, John G. Dennett, Jr.
  • Patent number: D930870
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: September 14, 2021
    Inventor: Julio Aguirre