Patents by Inventor Julio Alvarez
Julio Alvarez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7183910Abstract: A location-based service includes detecting the relative motion of an on-site resource, such as a shopping cart, in addition to detecting the absolute position of the on-site resource, and displaying information on the on-site resource. The displayed information is based upon the detected relative motion and the detected absolute position. The relative motion is tracked and a position on a floor plan is deduced. This deduced position is adjusted, for example, synchronized or reset, as a function of and in response to the detected absolute position.Type: GrantFiled: December 17, 2004Date of Patent: February 27, 2007Assignee: International Business Machines CorporationInventors: Julio Alvarez, Phuc Ky Do, Justin Monroe Pierce, Susan Elizabeth Wince
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Publication number: 20060229306Abstract: New 4-aminothieno[2,3-d]pyrimidine-6-carbonitrile derivatives having the chemical structure of general formula (I), and pharmaceutically acceptable salts thereof are disclosed, as well as processes for their preparation and to pharmaceutical compositions containing them and their use in the treatment, prevention or suppression of pathological conditions, diseases and disorders susceptible of being improved by inhibition of PDE7.Type: ApplicationFiled: January 23, 2004Publication date: October 12, 2006Inventors: Emma Terricabras Belart, Victor Segarra Matamoros, Julio Alvarez-Builla Gomez, Juan Vaquero Lopez, Jose Minguez Ortega
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Publication number: 20060145838Abstract: A location-based service includes detecting the relative motion of an on-site resource, such as a shopping cart, in addition to detecting the absolute position of the on-site resource, and displaying information on the on-site resource. The displayed information is based upon the detected relative motion and the detected absolute position. The relative motion is tracked and a position on a floor plan is deduced. This deduced position is adjusted, for example, synchronized or reset, as a function of and in response to the detected absolute position.Type: ApplicationFiled: December 17, 2004Publication date: July 6, 2006Applicant: International Business Machines CorporationInventors: Julio Alvarez, Phuc Do, Justin Pierce, Susan Wince
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Patent number: 7068150Abstract: A system receives AC power from an Uninterruptable Power Supply (UPS) on an AC power cable. The AC power cable couples a primary AC line voltage or a switched secondary AC line voltage depending on the quality of the primary AC line voltage. The UPS has a modulating circuit with a power line carrier protocol that receives a power down signal from the UPS if the primary AC line voltage indicates that the system should power down in a controlled manner or take other power down actions. The modulating circuit generates a modulated power down signal that is coupled to the AC power cable. The system has a corresponding demodulating receiving circuit with the power line carrier protocol that receives the modulated power down signal and regenerates the power down signal. The power down signal is coupled to circuitry in the system that initiates power down sequencing options.Type: GrantFiled: February 25, 2003Date of Patent: June 27, 2006Assignee: International Business Machines CorporationInventors: Julio Alvarez, Richard John Kairis, Jr.
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Publication number: 20060136285Abstract: A location-based service includes detecting the relative motion of an on-site resource, detecting the absolute position of the on-site resource, and tracking the position of the on-site resource. The position is tracked by deriving a deduced position based on the detected relative motion and adjusting the deduced position as a function of and in response to the detected absolute position. According to one embodiment, the on-site resource can be a shopping cart and the tracking includes recording a travel pattern of the shopping cart as it moves through a site floor plan such that the travel pattern is reproducible. Preferably, the recorded travel pattern includes travel patterns within an aisle in the site floor plan such that the recorded patterns include travel along the length of the aisle and travel having components which are perpendicular to the length of the aisle.Type: ApplicationFiled: December 17, 2004Publication date: June 22, 2006Applicant: International Business Machines CorporationInventors: Julio Alvarez, Phuc Do, Justin Pierce, Susan Wince
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Patent number: 7064140Abstract: The present invention relates to pharmaceutical combinations of opioid and non-opioid analgesics in an intimate admixture with caffeine and an analgesic from a series of N-acylated 4-hydroxyphenylamine derivatives, linked via an alkylene bridge to the nitrogen atom of a 1,2-benzisothiazol-3(2H)-one 1,1-dioxide group and methods for their use to alleviate pain in mammals. The analgesic combinations exhibit enhanced analgesic potency and are free from antipyretic activity, do not suppress blood coagulation, and have little hepatotoxic effect.Type: GrantFiled: June 12, 2003Date of Patent: June 20, 2006Inventors: Carlos Sunkel, Nicolas G. Bazan, Dennis Paul, Julio Alvarez-Builla
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Patent number: 6987105Abstract: A new method to synthesize the platelet-activating factor antagonist which is a derivative of thienotriazolodiazepene, tetrahydro-4,7,8,10 methyl-1(chloro-2 phenyl)-6 (methosy-4 phenyl carbamoyl)-9 pyrido[4,3-:4,5] thieno[3,2-f] triazolo-1,2,4 [4,3-?] diazepine-1,4] (1) is disclosed. The compound synethesized by this new method has been designated “LAU-8080” which has the same structure as the compound currently named in the literature as “BN-50730.” LAU-8080 was shown to prevent photoreceptor cell death, inhibit pathological neovascularization in the retina, and minimize the loss of neurons due to ischemic-reperfusion damage due to stroke. Thus LAU-8080 can be used to treat the retinal diseases of age-related macular degeneration, retinitis pigmentosa, and diabetic retinopathy. It can also be used to minimize the neuronal damage due to stroke.Type: GrantFiled: April 26, 2001Date of Patent: January 17, 2006Assignee: Board of Supervisors of Louisiana State University And Agricultural and Mechanical CollegeInventors: Nicholas G. Bazan, Julio Alvarez Builla Gomez
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Patent number: 6979682Abstract: A novel use of platelet-activating factor antagonists that bind to intracellular PAF binding sites such as BN-50730 (tetrahedra-4,7,8,10 methyl-1 (chloro-1 phenyl)-6 (methoxy-4 phenyl-carbamoyl)-9 pyrido [4?,3?-4,5] thieno [3,2-f] triazolo-1,2,4 [4,3-a] diazepine-1,4) has been discovered. These intracellular-binding platelet-activating factor antagonists were found to inhibit both in vivo and in vitro tumor growth and angiogenesis where the angiogenesis is stimulated by basic fibroblast growth factor.Type: GrantFiled: February 25, 2002Date of Patent: December 27, 2005Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Jay D. Hunt, Haydee E. Bazan, Victor L. Marcheselli, Julio Alvarez Builla Gomez, Nicholas G. Bazan
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Patent number: 6864271Abstract: The present invention relates to pharmaceutical combinations of opioid and non-opioid analgesics in an intimate admixture with an analgesic from a series of N-acylated 4-hydroxyphenylamine derivatives, linked via an alkylene bridge to the nitrogen atom of a 1,2-benzisothiazol-3(2H)-one 1,1-dioxide group and methods for their use to alleviate pain in mammals. The analgesic combinations exhibit enhanced analgesic potency, do not suppress blood coagulation, and have little hepatotoxic effect.Type: GrantFiled: November 12, 2002Date of Patent: March 8, 2005Assignee: The Foundation for the LSU Health Sciences CenterInventors: Nicolas G. Bazan, Dennis Paul, Carlos Sunkel, Julio Alvarez-Builla
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Publication number: 20040254207Abstract: The present invention relates to pharmaceutical combinations of opioid and non-opioid analgesics in an intimate admixture with caffeine and an analgesic from a series of N-acylated 4-hydroxyphenylamine derivatives, linked via an alkylene bridge to the nitrogen atom of a 1,2-benzisothiazol-3(2H)-one 1,1-dioxide group and methods for their use to alleviate pain in mammals. The analgesic combinations exhibit enhanced analgesic potency and are free from antipyretic activity, do not suppress blood coagulation, and have little hepatotoxic effect.Type: ApplicationFiled: June 12, 2003Publication date: December 16, 2004Inventors: Carlos Sunkel, Nicolas G. Bazan, Dennis Paul, Julio Alvarez-Builla
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Patent number: 6806291Abstract: New analgesic compounds, which are prepared by the hydrolysis of N-acylated 4-hydroxyphenylamine derivatives, their synthesis and pharmaceutical compositions containing them are disclosed. These compounds surprisingly possess high analgesic activity with little hepatotoxic effect, making them more useful than conventional non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of chronic pain.Type: GrantFiled: October 9, 2003Date of Patent: October 19, 2004Assignee: The Foundation for the LSU Health Sciences CenterInventors: Carlos Sunkel, Julio Alvarez-Builla, Nicolas G. Bazan, Anthony Vaccarino
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Publication number: 20040164849Abstract: A system receives AC power from an Uninterruptable Power Supply (UPS) on an AC power cable. The AC power cable couples a primary AC line voltage or a switched secondary AC line voltage depending on the quality of the primary AC line voltage. The UPS has a modulating circuit with a power line carrier protocol that receives a power down signal from the UPS if the primary AC line voltage indicates that the system should power down in a controlled manner or take other power down actions. The modulating circuit generates a modulated power down signal that is coupled to the AC power cable. The system has a corresponding demodulating receiving circuit with the power line carrier protocol that receives the modulated power down signal and regenerates the power down signal. The power down signal is coupled to circuitry in the system that initiates power down sequencing options.Type: ApplicationFiled: February 25, 2003Publication date: August 26, 2004Applicant: International Business Machines CorporationInventors: Julio Alvarez, Richard John Kairis
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Publication number: 20040092541Abstract: The present invention relates to pharmaceutical combinations of opioid and non-opioid analgesics in an intimate admixture with an analgesic from a series of N-acylated 4-hydroxyphenylamine derivatives, linked via an alkylene bridge to the nitrogen atom of a 1,2-benzisothiazol-3(2H)-one 1,1-dioxide group and methods for their use to alleviate pain in mammals. The analgesic combinations exhibit enhanced analgesic potency and are free from antipyretic activity, do not suppress blood coagulation, and have little hepatotoxic effect.Type: ApplicationFiled: November 12, 2002Publication date: May 13, 2004Inventors: Nicolas G. Bazan, Dennis Paul, Julio Alvarez-Builla, Carlos Sunkel
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Publication number: 20030229078Abstract: A new method to synthesize the platelet-activating factor antagonist which is a derivative of thienotriazolodiazepene, tetrahydro-4,7,8,10 methyl-1(chloro-2 phenyl)-6 (methosy-4 phenyl carbamoyl)-9 pyrido[4,3-:4,5] thieno[3,2-f] triazolo-1,2,4 [4,3-&agr;] diazepine-1,4] (1) is disclosed. The compound synethesized by this new method has been designated “LAU-8080” which has the same structure as the compound currently named in the literature as “BN-50730.” LAU-8080 was shown to prevent photoreceptor cell death, inhibit pathological neovascularization in the retina, and minimize the loss of neurons due to ischemic-reperfusion damage due to stroke. Thus LAU-8080 can be used to treat the retinal diseases of age-related macular degeneration, retinitis pigmentosa, and diabetic retinopathy. It can also be used to minimize the neuronal damage due to stroke.Type: ApplicationFiled: March 10, 2003Publication date: December 11, 2003Inventors: Nicholas G Bazan, Julio Alvarez Builla Gomez
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Patent number: 6653311Abstract: We have synthesized a series of new derivatives of (2-azinylamino) quinone, that have the general formula shown below. Several compounds of this new series of derivatives have been shown to be inhibitors of 5-lipoxygenase, with minimal or no effect on cycloxygenase-1 and 2-(COX-1 and COX-2) activity. where: A is N, CH, or, CCl; B is N, CH, CCH3, or Cph; X is H, Cl, Br, or I; Y is H, or CH3; R1 is H, CH3, OCH3, or Ph; and R2 is H, CH3, OCH3, or Ph; or R1—R2 is (CH═CH)2; and R3 is H or CH3.Type: GrantFiled: June 25, 2002Date of Patent: November 25, 2003Assignees: Board of Supervisors of Louisiana State University, Agricultural and Mechanical CollegeInventors: Nicholas G. Bazan, Carlos Sunkel, Julio Alvarez Builla-G.
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Patent number: 6482841Abstract: The present invention is concerned with new pyridine double esters of formula (I), their acids, and pharmaceutically acceptable salts. These compounds can be obtained by oxydation of the corresponding 1,4-dihydropyridines, and they are useful as cardioprotective agents in pharmaceutical compositions.Type: GrantFiled: April 7, 2000Date of Patent: November 19, 2002Assignee: Cermol S.A.Inventors: Carlos Sunkel Letelier, Miguel Fau De Casa-Juana Munoz, Julio Alvarez-Builla Gomez, José M. Minguez Ortega, Pierre Statkow, Danielle Straumann, Shyam S. Chatterjee
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Publication number: 20020169158Abstract: A novel use of platelet-activating factor antagonists that bind to intracellular PAF binding sites such as BN-50730 (tetrahedra-4,7,8,10 methyl-1 (chloro-1 phenyl)-6 (methoxy-4 phenyl-carbamoyl)-9 pyrido [4′,3′-4,5] thieno [3,2-f] triazolo-1,2,4 [4,3-a] diazepine-1,4) has been discovered. These intracellular-binding platelet-activating factor antagonists were found to inhibit both in vivo and in vitro tumor growth and angiogenesis where the angiogenesis is stimulated by basic fibroblast growth factor.Type: ApplicationFiled: February 25, 2002Publication date: November 14, 2002Inventors: Jay D. Hunt, Haydee E. Bazan, Victor L. Marcheselli, Julio Alvarez Builla Gomez, Nicholas G. Bazan
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Patent number: 5621110Abstract: The present invention relates to a series of new N-acylated 4-hydroxyphenylamine derivatives, linked via an alkylene bridge to the nitrogen atom of a 1,2-benzisothiazol-3(2H)-one 1,1-dioxide group of formula I: ##STR1## in which n is a number from 1 to 5, and to processes for preparing these derivatives and to pharmaceutical compositions containing said derivatives; these compounds possess high analgesic activity free from antipyretic activity, and they display little hepatotoxic effect.Type: GrantFiled: September 18, 1995Date of Patent: April 15, 1997Assignee: LSU Medical Center FoundationInventors: Nicolas G. Bazan, Julio Alvarez-Builla Gomez
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Patent number: 5554636Abstract: The present invention relates to a series of new N-acylated 4-hydroxyphenylamine derivatives, linked via an alkylene bridge to the nitrogen atom of a 1,2-benzisothiazol-3(2H)-one 1,1-dioxide group, of formula I: ##STR1## in which n is a number from 1 to 5, and to processes for preparing these derivatives and to pharmaceutical compositions containing said derivatives; these compounds possess high analgesic activity free from antipyretic activity, and they display little hepatotoxic effect.Type: GrantFiled: April 21, 1995Date of Patent: September 10, 1996Assignee: LSU Medical Center FoundationInventors: Nicolas G. Bazan, Julio Alvarez-Builla Gomez
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Patent number: 4880894Abstract: Novel quaternary ammonium salts of general formula (I) ##STR1## wherein: R is a saturated or unsaturated, linear or branched alkyl radical of C.sub.1 to C.sub.8.R' is a saturated or unsaturated, linear or branched alkyl radical of C.sub.1 to C.sub.12, or a benzyl radical.n is a number equal to 2 or 3.X.sup..theta. is a halogenide anion, such as Cl.sup..theta., Br.sup..theta., I.sup..theta., are used as phase transfer catalysts, in heterogeneous ionic reactions wherein the reagents are in different phase and have different polarity.Type: GrantFiled: September 26, 1988Date of Patent: November 14, 1989Assignee: Alter, S.A.Inventors: Carlos Sunkel, Miguel Fay de Casa Juana, Fernando Dorrego, Basilio Pando, Julio Alvarez-Builla, Juan J. Vaquero, Carlos Galera, Maria L. Vazquez