Patents by Inventor Julio C. Spinelli

Julio C. Spinelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9669225
    Abstract: A cardiac rhythm management system selects one of multiple electrodes associated with a particular heart chamber based on a relative timing between detection of a depolarization fiducial point at the multiple electrodes, or based on a delay between detection of a depolarization fiducial point at the multiple electrodes and detection of a reference depolarization fiducial point at another electrode associated with the same or a different heart chamber. Subsequent contraction-evoking stimulation therapy is delivered from the selected electrode.
    Type: Grant
    Filed: January 18, 2016
    Date of Patent: June 6, 2017
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Jiang Ding, Julio C. Spinelli, Andrew P. Kramer
  • Publication number: 20160129255
    Abstract: A cardiac rhythm management system selects one of multiple electrodes associated with a particular heart chamber based on a relative timing between detection of a depolarization fiducial point at the multiple electrodes, or based on a delay between detection of a depolarization fiducial point at the multiple electrodes and detection of a reference depolarization fiducial point at another electrode associated with the same or a different heart chamber. Subsequent contraction-evoking stimulation therapy is delivered from the selected electrode.
    Type: Application
    Filed: January 18, 2016
    Publication date: May 12, 2016
    Inventors: Jiang Ding, Julio C. Spinelli, Andrew P. Kramer
  • Patent number: 9265950
    Abstract: A cardiac rhythm management system detects edema. In response to an episode of detected edema, it initiates or adjusts a cardiac resynchronization therapy and/or a cardiac contractility modulation (CCM) therapy.
    Type: Grant
    Filed: May 12, 2008
    Date of Patent: February 23, 2016
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Qingsheng Zhu, Julio C. Spinelli
  • Patent number: 9248295
    Abstract: Response to cardiac resynchronization therapy is predicted for a given stimulation site so that an atrioventricular delay of an implantable device administering cardiac resynchronization therapy may be set to a proper amount. The first deflection of ventricular depolarization is measured, such as through a surface electrocardiogram or through an intracardiac electrogram measured by a lead positioned in the heart at the stimulation site. The maximum deflection of the ventricular depolarization is then measured by the lead positioned at the stimulation site. The interval of time between the first deflection and the maximum deflection of the ventricular depolarization is compared to a threshold to determine whether the stimulation site is a responder site. If the interval is larger than the threshold, then the site is a responder and the atrioventricular delay of the implantable device may be set to less than the intrinsic atrioventricular delay of the patient.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: February 2, 2016
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Julio C. Spinelli, Yinghong Yu
  • Patent number: 9242099
    Abstract: A cardiac rhythm management system selects one of multiple electrodes associated with a particular heart chamber based on a relative timing between detection of a depolarization fiducial point at the multiple electrodes, or based on a delay between detection of a depolarization fiducial point at the multiple electrodes and detection of a reference depolarization fiducial point at another electrode associated with the same or a different heart chamber. Subsequent contraction-evoking stimulation therapy is delivered from the selected electrode.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: January 26, 2016
    Assignee: Cardiac Pacemarkers, Inc.
    Inventors: Jiang Ding, Julio C. Spinelli, Andrew P. Kramer
  • Patent number: 9216289
    Abstract: A neural stimulation system senses autonomic activities and applies neural stimulation to sympathetic and parasympathetic nerves to control autonomic balance. The neural stimulation system is capable of delivering neural stimulation pulses for sympathetic excitation, sympathetic inhibition, parasympathetic excitation, and parasympathetic inhibition.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: December 22, 2015
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Imad Libbus, Andrew P. Kramer, Julio C. Spinelli
  • Patent number: 9061156
    Abstract: A method and apparatus for selection of one or more ventricular chambers to stimulate for ventricular resynchronization therapy. Intrinsic intracardia electrograms that include QRS complexes, are recorded from a left and right ventricle. A timing relationship between the intrinsic intracardia electrograms recorded from the left and right ventricle is then determined. In one embodiment, the timing relationship is determined using a delay between a left ventricular and a right ventricular sensed intrinsic ventricular depolarizations and a duration interval of one or more QRS complexes. In one embodiment, the duration of QRS complexes is determined from either intracardiac electrograms or from surface ECG recordings. One or more ventricular chambers in which to provide pacing pulses are then selected based on the timing relationship between intrinsic intracardia electrograms recorded from the right and left ventricle, and the duration of one or more QRS complexes.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: June 23, 2015
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Jiang Ding, Julio C. Spinelli, Yinghong Yu, Andrew P. Kramer
  • Patent number: 9037233
    Abstract: A device and method for delivering high-energy electrical stimulation to the heart in order to improve cardiac function in heart failure patients. The high-energy stimulation mimics the effects of exercise and improves symptoms even in patients who are exercise intolerant. The high-energy stimulation may be delivered on an intermittent basis either as pacing pulses in accordance with a programmed pacing mode and with a higher pacing pulse energy than used for conventional pacing or as low energy shock pulses.
    Type: Grant
    Filed: July 19, 2010
    Date of Patent: May 19, 2015
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Joseph M. Pastore, Imad Libbus, Andrew P. Kramer, Julio C. Spinelli
  • Patent number: 8897881
    Abstract: Various system embodiments comprise a neural stimulation delivery system adapted to deliver a neural stimulation signal for use in delivering a neural stimulation therapy, a side effect detector, and a controller. The controller is adapted to control the neural stimulation delivery system, receive a signal indicative of detected side effect, determine whether the detected side effect is attributable to delivered neural stimulation therapy, and automatically titrate the neural stimulation therapy to abate the side effect. In various embodiments, the side effect detector includes a cough detector. In various embodiments, the controller is adapted to independently adjusting at least one stimulation parameter for at least one phase in the biphasic waveform as part of a process to titrate the neural stimulation therapy. Other aspects and embodiments are provided herein.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: November 25, 2014
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Imad Libbus, Julio C. Spinelli
  • Publication number: 20140330330
    Abstract: A method and apparatus for selection of one or more ventricular chambers to stimulate for ventricular resynchronization therapy. Intrinsic intracardia electrograms that include QRS complexes, are recorded from a left and right ventricle. A timing relationship between the intrinsic intracardia electrograms recorded from the left and right ventricle is then determined. In one embodiment, the timing relationship is determined using a delay between a left ventricular and a right ventricular sensed intrinsic ventricular depolarizations and a duration interval of one or more QRS complexes. In one embodiment, the duration of QRS complexes is determined from either intracardiac electrograms or from surface ECG recordings. One or more ventricular chambers in which to provide pacing pulses are then selected based on the timing relationship between intrinsic intracardia electrograms recorded from the right and left ventricle, and the duration of one or more QRS complexes.
    Type: Application
    Filed: July 17, 2014
    Publication date: November 6, 2014
    Inventors: Jiang Ding, Julio C. Spinelli, Yinghong Yu, Andrew P. Kramer
  • Patent number: 8849399
    Abstract: Methods and systems are disclosed for determining whether a patient is a responder to cardiac resynchronization therapy. The beginning and ending of the intrinsic ventricular depolarization are determined through signals measured from one or more electrodes implanted in the patient's heart. An interval between the beginning and ending of the intrinsic ventricular depolarization is computed and is compared to a threshold. The threshold may be determined empirically. The pacing parameters of a heart stimulation device, such as a pacemaker, may then be configured, for example, by setting the paced atrio-ventricular delay based on whether the patient responds positively to cardiac resynchronization therapy.
    Type: Grant
    Filed: October 1, 2013
    Date of Patent: September 30, 2014
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Jiang Ding, Yinghong Yu, Julio C. Spinelli
  • Patent number: 8818511
    Abstract: A method and apparatus for selection of one or more ventricular chambers to stimulate for ventricular resynchronization therapy. Intrinsic intracardia electrograms that include QRS complexes, are recorded from a left and right ventricle. A timing relationship between the intrinsic intracardia electrograms recorded from the left and right ventricle is then determined. In one embodiment, the timing relationship is determined using a delay between a left ventricular and a right ventricular sensed intrinsic ventricular depolarizations and a duration interval of one or more QRS complexes. In one embodiment, the duration of QRS complexes is determined from either intracardiac electrograms or from surface ECG recordings. One or more ventricular chambers in which to provide pacing pulses are then selected based on the timing relationship between intrinsic intracardia electrograms recorded from the right and left ventricle, and the duration of one or more QRS complexes.
    Type: Grant
    Filed: June 8, 2009
    Date of Patent: August 26, 2014
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Jiang Ding, Julio C. Spinelli, Yinghong Yu, Andrew P. Kramer
  • Publication number: 20140194952
    Abstract: A neural stimulation system senses autonomic activities and applies neural stimulation to sympathetic and parasympathetic nerves to control autonomic balance. The neural stimulation system is capable of delivering neural stimulation pulses for sympathetic excitation, sympathetic inhibition, parasympathetic excitation, and parasympathetic inhibition.
    Type: Application
    Filed: March 11, 2014
    Publication date: July 10, 2014
    Applicant: Cardiac Pacemakers, Inc.
    Inventors: Imad Libbus, Andrew P. Kramer, Julio C. Spinelli
  • Patent number: 8755897
    Abstract: One embodiment includes a system for prescribing therapeutic treatment for a patient via communications over a network, including an implantable medical device (IMD) to be implanted in the patient to record a patient characteristic, the implantable medical device being programmable and configured to communicate via wireless communications with the IMD and to communicate securely over the network, the medical device programming computer including a user interface. The embodiment includes a server to communicate securely over the network with the medical device programming computer, the server including at least a first expert prescription system comprising at least one physician's prescription and at least one expert-system to compare the at least one patient characteristic to the at least one physician's prescription to issue a parameter to be programmed into the IMD based on the comparison.
    Type: Grant
    Filed: November 19, 2007
    Date of Patent: June 17, 2014
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Julio C. Spinelli, Qingsheng Zhu
  • Publication number: 20140142649
    Abstract: Response to cardiac resynchronization therapy is predicted for a given stimulation site so that an atrioventricular delay of an implantable device administering cardiac resynchronization therapy may be set to a proper amount. The first deflection of ventricular depolarization is measured, such as through a surface electrocardiogram or through an intracardiac electrogram measured by a lead positioned in the heart at the stimulation site. The maximum deflection of the ventricular depolarization is then measured by the lead positioned at the stimulation site. The interval of time between the first deflection and the maximum deflection of the ventricular depolarization is compared to a threshold to determine whether the stimulation site is a responder site. If the interval is larger than the threshold, then the site is a responder and the atrioventricular delay of the implantable device may be set to less than the intrinsic atrioventricular delay of the patient.
    Type: Application
    Filed: January 27, 2014
    Publication date: May 22, 2014
    Applicant: Cardiac Pacemakers, Inc.
    Inventors: Julio C. Spinelli, Yinghong Yu
  • Patent number: 8731677
    Abstract: Various system embodiments comprise a neural stimulator, a pulse generator, and a controller. The neural stimulator is adapted to generate a neural stimulation signal. The pulse generator is adapted to generate a pacing signal to provide myocardium pacing. The controller is adapted to control the neural stimulator and the pulse generator to provide a cardioprotective conditioning therapy. The conditioning therapy includes neural stimulation to elicit a parasympathetic response and myocardium pacing. Other aspects and embodiments are provided herein.
    Type: Grant
    Filed: February 10, 2010
    Date of Patent: May 20, 2014
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Joseph M. Pastore, Tamara Colette Baynham, Andrew P. Kramer, Julio C. Spinelli, Jeffrey Ross, Rodney W. Salo
  • Publication number: 20140121729
    Abstract: An aspect of the present subject matter relates to a baroreflex stimulator. An embodiment of the stimulator includes a pulse generator to provide a baroreflex stimulation signal through an electrode, and a modulator. The modulator modulates the baroreflex stimulation signal to increase the baroreflex stimulation therapy by a predetermined rate of change to lower systemic blood pressure to a target pressure. Other aspects are provided herein.
    Type: Application
    Filed: January 6, 2014
    Publication date: May 1, 2014
    Applicant: Cardiac Pacemakers, Inc.
    Inventors: Imad Libbus, Julio C. Spinelli
  • Patent number: 8682430
    Abstract: A neural stimulation system senses autonomic activities and applies neural stimulation to sympathetic and parasympathetic nerves to control autonomic balance. The neural stimulation system is capable of delivering neural stimulation pulses for sympathetic excitation, sympathetic inhibition, parasympathetic excitation, and parasympathetic inhibition.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 25, 2014
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Imad Libbus, Andrew P. Kramer, Julio C. Spinelli
  • Publication number: 20140074178
    Abstract: A cardiac rhythm management system selects one of multiple electrodes associated with a particular heart chamber based on a relative timing between detection of a depolarization fiducial point at the multiple electrodes, or based on a delay between detection of a depolarization fiducial point at the multiple electrodes and detection of a reference depolarization fiducial point at another electrode associated with the same or a different heart chamber. Subsequent contraction evoking stimulation therapy is delivered from the selected electrode.
    Type: Application
    Filed: November 26, 2013
    Publication date: March 13, 2014
    Applicant: Cardiac Pacemakers, Inc.
    Inventors: Jiang Ding, Julio C. Spinelli, Andrew P. Kramer
  • Publication number: 20140031887
    Abstract: Methods and systems are disclosed for determining whether a patient is a responder to cardiac resynchronization therapy. The beginning and ending of the intrinsic ventricular depolarization are determined through signals measured from one or more electrodes implanted in the patient's heart. An interval between the beginning and ending of the intrinsic ventricular depolarization is computed and is compared to a threshold. The threshold may be determined empirically. The pacing parameters of a heart stimulation device, such as a pacemaker, may then be configured, for example, by setting the paced atrio-ventricular delay based on whether the patient responds positively to cardiac resynchronization therapy.
    Type: Application
    Filed: October 1, 2013
    Publication date: January 30, 2014
    Applicant: Cardiac Pacemakers, Inc.
    Inventors: Jiang Ding, Yinghong Yu, Julio C. Spinelli