Patents by Inventor Julio Campon Pardo

Julio Campon Pardo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8183370
    Abstract: Process for removal of the amino protective group of a N-acylated {(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-cyclopent-2-enyl}methanol of formula (II) where R?H or a (C1-C4)-alkyl, using an inorganic base in a mixture of water and alcohol, to yield abacavir or its salts. The process proceeds very fast and the product can be obtained in high yield and purity.
    Type: Grant
    Filed: September 27, 2007
    Date of Patent: May 22, 2012
    Assignee: Esteve Quimica, SA
    Inventors: Jorge Medrano Rupérez, Julio Campon Pardo, Laia Elías Rius, Ramón Berenguer Maimó
  • Patent number: 8097723
    Abstract: Process for the preparation of abacavir, or its salts or its solvates comprising the step of reacting a compound (IV) where R1 is a (C1-C4)-alkyl radical with anhydrous hydrochloric acid/(C1-C6)-alcohol, and then with tri(C1-C4)-alkyl orthoformate, in the absence of water. The preparation process may include further steps of reacting the compound obtained with cyclopropylamine and subsequently hydrolysis to yield abacavir.
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: January 17, 2012
    Assignee: Esteve Quimica, S.A.
    Inventors: Jorge Medrano Rupérez, Julio Campon Pardo, Laia Elías Rius, Ramón Berenguer Maimó
  • Publication number: 20100041883
    Abstract: Process for the preparation of abacavir, or its salts or its solvates comprising the step of reacting a compound (IV) where R1 is a (C1-C4)-alkyl radical with anhydrous hydrochloric acid/(C1-C6)-alcohol, and then with tri(C1-C4)-alkyl orthoformate, in the absence of water. The preparation process may include further steps of reacting the compound obtained with cyclopropylamine and subsequently hydrolysis to yield abacavir.
    Type: Application
    Filed: December 20, 2007
    Publication date: February 18, 2010
    Applicant: ESTEVE QUÍMICA, S.A.
    Inventors: Jorge Medrano Rupérez, Julio Campon Pardo, Laia Elías Rius, Ramón Berenguer Maimó
  • Publication number: 20100004446
    Abstract: Process for removal of the amino protective group of a N-acylated [(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-cyclopent-2-enyl]methanol of formula (II) where R?H or a (C1-C4)-alkyl, using an inorganic base in a mixture of water and alcohol, to yield abacavir or its salts. The process proceeds very fast and the product can be obtained in high yield and purity.
    Type: Application
    Filed: September 27, 2007
    Publication date: January 7, 2010
    Applicant: ESTEVE QUÍMICA, S.A.
    Inventors: Jorge Medrano Rupérez, Julio Campon Pardo, Laia Elías Rius, Ramón Berenguer Maimó
  • Patent number: 6635773
    Abstract: Process for preparing purified citalopram or one of its salts that comprises the purification of citalopram by selective extractions of citalopram or of its impurities with organic solvents and water under specific conditions of pH and temperature. The crude citalopram can be prepared by a process that comprises reacting 1-[3-(dimethylamine)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-bromoisobenzofuran with copper cyanide.
    Type: Grant
    Filed: January 24, 2003
    Date of Patent: October 21, 2003
    Assignee: Esteve Quimica, S.A.
    Inventors: Laura Coppi, Yolanda Gasanz Guillen, Julio Campon Pardo
  • Patent number: 6603006
    Abstract: An intermediate for the synthesis of amlodipine, a process for the preparation thereof and the corresponding use are disclosed. The intermediate is ethyl 3-amino-4-(2-(phthalimido)ethoxy)crotonate and is of formula III: The process for the preparation thereof comprises reacting the acetoacetate of formula: with ammonium acetate; and the use thereof is for the preparation of the compound of formula: the process being conducted by reacting ethyl 3-amino-4-[2-(phthalimido)ethoxy]crotonate with a benzylidene derivative.
    Type: Grant
    Filed: January 10, 2002
    Date of Patent: August 5, 2003
    Assignee: Esteve Química, S.A.
    Inventors: Laura Coppi, Yolanda Gasanz Guillén, Julio Campón Pardo
  • Patent number: 6603009
    Abstract: The present invention relates to a procedure for the oxidation of a thioether group to a sulfoxide group, with aqueous sodium percarbonate in the presence of a molybdenum salt as a catalyst. The procedure is of application to oxidize the thioether group of a compound (I), where R1 is a C1-C6 alkyl, a halogenated C1-C6 alkyl, or —(CH2)n—OR9, where n is an integer between 1 and 6 and R9 is H or a C1-C6 alkyl; R2, R3, R4, R5, R6 and R8, independently form each other represent H, a C1-C6 alkyl, or C1-C6 alkoxy; and R7 is H, a C1-C6 alkyl, a C1-C6 alkoxy or a C1-C6 fluorinated alkoxy, in order to obtain the sulfinyl derivative (II).
    Type: Grant
    Filed: August 20, 2002
    Date of Patent: August 5, 2003
    Assignee: Esteve Quimica, S.A.
    Inventors: Ramon Berenguer Maimo, Julio Campon Pardo, Laura Coppi
  • Publication number: 20030144534
    Abstract: Process for preparing purified citalopram or one of its salts that comprises the purification of citalopram by selective extractions of citalopram or of its impurities with organic solvents and water under specific conditions of pH and temperature. The crude citalopram can be prepared by a process that comprises reacting 1-[3-(dimethylamine)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-bromoisobenzofuran with copper cyanide.
    Type: Application
    Filed: January 24, 2003
    Publication date: July 31, 2003
    Inventors: Laura Coppi, Yolanda Gasanz Guillen, Julio Campon Pardo
  • Publication number: 20020068831
    Abstract: An intermediate for the synthesis of amlodipine, a process for the preparation thereof and the corresponding use are disclosed.
    Type: Application
    Filed: January 10, 2002
    Publication date: June 6, 2002
    Applicant: ESTEVE QUIMICA, S.A.
    Inventors: Laura Coppi, Yolanda Gasanz Guillen, Julio Campon Pardo
  • Patent number: 5082969
    Abstract: Industrial process for obtaining an aryloxypropanolamine of chemical name 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol, characterized in that it comprises the following operating phases. By reacting 4-(2-methoxyethyl)phenol with epichlorohydrin in an alkaline aqueous medium at temperatures of between 0.degree. and 25.degree. C. a crude reaction product composed to the extent of 75-80% of 3-[4-(2-methoxyethyl)phenoxy]-1,2-epoxypropane and to the extent of 15-20% of 1-[4-(2-methoxyethyl)phenoxy]-3-chloro-2-propanol is obtained, after the appropriate extractions and washings, both compounds being suitable for reacting with isopropylamine in an aqueous medium and at temperatures ranging between 0.degree. and 30.degree. C. to obtain the desired aryloxypropanolamine of formula I.
    Type: Grant
    Filed: May 16, 1990
    Date of Patent: January 21, 1992
    Assignee: Esteve Quimica, S.A.
    Inventors: Josep M. Ribalta Baro, Gloria Oranias Olsina, Julio Campon Pardo
  • Patent number: 4797483
    Abstract: A process for obtaining 4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide, which may be used as a non-steroidal analgesic and anti-inflammatory drug. The process comprises reacting saccharin sodium with isopropyl chloroacetate in dimethylformamide, reacting the resultant isopropyl 3-oxo-1,2-benzoisothiazoline-2-acetate 1,1-dioxide with sodium isopropylate in isopropanol to produce an intermediate which, when methylated in an aqueous-alcoholic basic medium with dimethyl sulfate, gives an intermediate compound which when condensed with 2-aminopyridine in xylene, yields 4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazone-3-carboxamide 1,1-dioxide.
    Type: Grant
    Filed: June 24, 1987
    Date of Patent: January 10, 1989
    Assignee: Induspol, S.A.
    Inventors: Jordi Frigola Constansa, Jose M. Ribalta Baro, Julio Campon Pardo