Abstract: The present invention relates to use of pharmaceutical compositions that have as active ingredient the basic form of recombinant human erythropoietin (rhEPO) and that are administered nasally for the treatment of spinocerebellar ataxia (SCA) with mutations of CAG repeats type, particularly of SCA type 2. Another object of the present invention is a method for stratifying patients into responders and non-responders to treatment with the basic form of rhEPO.

Abstract: Provided is a process of correlating information organized according to a logical architecture of a distributed application to information organized according to a network architecture of computers executing the distributed application, the process including: obtaining a logical-architecture topology of a logical architecture of a distributed application executing on a plurality of computing devices; obtaining a network-architecture topology of a physical architecture of the plurality of computing devices executing the distributed application; inferring pairs of logical-architecture host identifiers and network-architecture host identifiers that refer to the same computing device to produce a cross-namespace mapping that correlates the logical-architecture namespace with the network-architecture namespace; and storing the cross-namespace mapping in memory.

Abstract: Provided is a process including: receiving, with an infrastructure monitoring application, metrics and events from a plurality of infrastructure agents executing on a plurality of computing devices; receiving an event record from a given computing device among a plurality of computing devices executing the distributed application; accessing a plurality of parameters of a computing device associated with the device identifier; determining one or more network-architecture topology host identifiers based on the plurality of parameters; and storing in memory a correlation between the event record and the one or more network-architecture topology host identifiers.

Abstract: Provided is a process including: receiving, with an infrastructure monitoring application, metrics and events from a plurality of infrastructure agents executing on a plurality of computing devices; receiving an event record from a given computing device among a plurality of computing devices executing the distributed application; accessing a plurality of parameters of a computing device associated with the device identifier; determining one or more network-architecture topology host identifiers based on the plurality of parameters; and storing in memory a correlation between the event record and the one or more network-architecture topology host identifiers.

Abstract: Provided is a process including: receiving, with an infrastructure monitoring application, metrics and events from a plurality of infrastructure agents executing on a plurality of computing devices; receiving an event record from a given computing device among a plurality of computing devices executing the distributed application; accessing a plurality of parameters of a computing device associated with the device identifier; determining one or more network-architecture topology host identifiers based on the plurality of parameters; and storing in memory a correlation between the event record and the one or more network-architecture topology host identifiers.

Abstract: Provided is a process of correlating information organized according to a logical architecture of a distributed application to information organized according to a network architecture of computers executing the distributed application, the process including: obtaining a logical-architecture topology of a logical architecture of a distributed application executing on a plurality of computing devices; obtaining a network-architecture topology of a physical architecture of the plurality of computing devices executing the distributed application; inferring pairs of logical-architecture host identifiers and network-architecture host identifiers that refer to the same computing device to produce a cross-namespace mapping that correlates the logical-architecture namespace with the network-architecture namespace; and storing the cross-namespace mapping in memory.

Abstract: Provided is a process including: receiving, with an infrastructure monitoring application, metrics and events from a plurality of infrastructure agents executing on a plurality of computing devices; receiving an event record from a given computing device among a plurality of computing devices executing the distributed application; accessing a plurality of parameters of a computing device associated with the device identifier; determining one or more network-architecture topology host identifiers based on the plurality of parameters; and storing in memory a correlation between the event record and the one or more network-architecture topology host identifiers.

Abstract: Techniques for processing infrastructure management data within a service domain are disclosed. The service domain includes service nodes that monitor respective target entities and that generate measurement data for target entities within the service domain. A database engine reads a serial measurement data stream that is generated by at least one of the service nodes. In response to reading the serial measurement data stream, the database engine generates a sequence of measurement data records that each contain target entity measurement data. The generated measurement data records further include metadata summary values and are recorded in a measurement database table in a logical access sequence that corresponds to the order in which the service nodes generated the measurement data.

Abstract: The invention relates to a vending machine comprising an integrated translucent or transparent LCD element, of the type that are used to sell products, said machine comprising a chassis (100) open on one side (3), the opening (3) being covered by a transparent or translucent LCD panel (2) in the form of a door, and containing a light source, said elements being connected and controlled by a computer (8) comprising a plurality of white LEDs (41) arranged peripherally around the inside of the LCD screen (2) and perpendicularly oriented towards the inside (101) of the machine, which is entirely white.

Abstract: An apparatus for use in gynaecological operations includes a support and a mounting assembly for mounting the support to an operating table. A vertical member is supported in a vertical orientation by the support and a horizontal bar is supported in a substantially horizontal orientation by the vertical member. An annular vaginal plug is supported by and is axially movable along the horizontal bar. A plug locking assembly is provided for locking the vaginal plug in a selected axial position along the horizontal bar. A uterine driver may be introduced through the abdominal wall that has a handle and a uterus engagement tip with omni-directional movement in the released position. The engagement tip is connected to the uterine driver by a flexible member.

Abstract: A method for allowing chronologically overlapping database transactions in a multi-threaded environment without the need for explicit thread synchronization for database access. Literal database connections are managed on a per thread basis, thus allowing different chronologically overlapping transactions in different threads. Four basic objects are used to accomplish the chronologically overlapping transactions in a multi-threaded environment. The environment object is a static object that creates and maintains a pointer to the database application environment handle in addition to performing basic error recovery and initialization functionality. The database object encapsulates a logical database connection. The database connection object contains the functions that can be performed on a database connection, such as transaction management and query creation. The database statement object encapsulates a query that can be made to the database.

Abstract: A method for allowing dynamic component activation using a database as a repository for registration information is disclosed. This method uses a Component Activation Manager (CAM), which is a singleton object that maps unique component ID's to a Factory Creation Function (FCF). A purpose of the FCF is to create and register factories for the objects contained in a dynamic library. The factories created with the FCF are also registered with a database connection created by the CAM. Using this approach, the application only needs to create the CAM object, request a connection and then request a factory for the objects it needs. The CAM and the database connection find the dynamic library and the associated object factories through the use of database tables that contain a map of unique component ID's and object FCF addresses.

Abstract: A method for allowing chronologically overlapping database transactions in a multi-threaded environment without the need for explicit thread synchronization for database access. Literal database connections are managed on a per thread basis, thus allowing different chronologically overlapping transactions in different threads. Four basic objects are used to accomplish the chronologically overlapping transactions in a multi-threaded environment. The environment object is a static object that creates and maintains a pointer to the database application environment handle in addition to performing basic error recovery and initialization functionality. The database object encapsulates a logical database connection. The database connection object contains the functions that can be performed on a database connection, such as transaction management and query creation. The database statement object encapsulates a query that can be made to the database.

Abstract: A method for allowing dynamic component activation using a database as a repository for registration information is disclosed. This method uses a Component Activation Manager (CAM), which is a singleton object that maps unique component ID's to a Factory Creation Function (FCF). A purpose of the FCF is to create and register factories for the objects contained in a dynamic library. The factories created with the FCF are also registered with a database connection created by the CAM. Using this approach, the application only needs to create the CAM object, request a connection and then request a factory for the objects it needs. The CAM and the database connection find the dynamic library and the associated object factories through the use of database tables that contain a map of unique component ID's and object FCF addresses.

Abstract: A method and structure for allowing object-oriented applications to create and configure caches for the objects used is disclosed. The method and structure use a general purpose cache integrated with object factories that provide the objects used by the application. The object factory can store objects in cache so that application requests for objects are returned in a fast and transparent manner to the calling application. A particular cache may support one or more object factories. The object factory that provides access to a cache is a specialized type of object factory, called a cacheable factory. The cacheable factory contains methods for adding, removing, and accessing objects in the cache associated with the cacheable factory object.

Abstract: A system and method for enforcing configuration parameters and detecting tampering of configuration files used by a software application. An enforced configuration packet (ECP) file generator generates an enforced configuration packet (ECP) file from a configuration parameter description file containing a set of configuration parameters. The ECP file includes a set of enforced configuration packets, which each include one of the configuration parameters from the ECP description file and a corresponding configuration parameter fingerprint unique to that particular configuration parameter. At startup of the software application, an ECP file reader validates the ECP file and each of the enforced configuration packets contained in the ECP file. Validation is achieved by regenerating the configuration parameter fingerprint of each configuration parameter and comparing the regenerated fingerprint to the fingerprint contained in the enforced configuration packet.