Patents by Inventor Julio Medina

Julio Medina has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190169084
    Abstract: Conjugates derived from non-steroidal anti-inflammatory drugs (NSAIDs) and methods of use thereof are disclosed, useful for, inter alia, identifying and localizing the site of pathology and/or inflammation responsible for the sensation of pain in a patient; for identifying the sites of primary, secondary, benign, or malignant tumors; and for diagnosing infection or confirming or ruling out suspected infection. The NSAID-based conjugates contain an imaging moiety. The conjugates concentrate at sites of increased cyclooxygenase expression, thus revealing the sites of increased prostaglandin production, which is correlated with pain and inflammation, and correlated with tumor presence and/or location. Identifying areas of increased COX expressing can also aid in screening for infections.
    Type: Application
    Filed: July 2, 2018
    Publication date: June 6, 2019
    Inventors: Mark A. REILEY, B. Michael SILBER, Julio MEDINA, Frank KAYSER, William D. SHRADER
  • Publication number: 20180162784
    Abstract: Conjugates derived from non-steroidal anti-inflammatory drugs (NSAIDs) and methods of use thereof are disclosed, useful for, inter alia, identifying and localizing the site of pathology and/or inflammation responsible for the sensation of pain in a patient; for identifying the sites of primary, secondary, benign, or malignant tumors; and for diagnosing infection or confirming or ruling out suspected infection. The NSAID-based conjugates contain an imaging moiety. The conjugates concentrate at sites of increased cyclooxygenase expression, thus revealing the sites of increased prostaglandin production, which is correlated with pain and inflammation, and correlated with tumor presence and/or location. Identifying areas of increased COX expressing can also aid in screening for infections.
    Type: Application
    Filed: November 9, 2017
    Publication date: June 14, 2018
    Inventors: Mark A. REILEY, B. Michael SILBER, Julio MEDINA, Frank KAYSER, William D. SHRADER
  • Patent number: 9850183
    Abstract: Conjugates derived from non-steroidal anti-inflammatory drugs (NSAIDs) and methods of use thereof are disclosed, useful for, inter alia, identifying and localizing the site of pathology and/or inflammation responsible for the sensation of pain in a patient; for identifying the sites of primary, secondary, benign, or malignant tumors; and for diagnosing infection or confirming or ruling out suspected infection. The NSAID-based conjugates contain an imaging moiety. The conjugates concentrate at sites of increased cyclooxygenase expression, thus revealing the sites of increased prostaglandin production, which is correlated with pain and inflammation, and correlated with tumor presence and/or location. Identifying areas of increased COX expressing can also aid in screening for infections.
    Type: Grant
    Filed: June 22, 2015
    Date of Patent: December 26, 2017
    Assignee: Reiley Pharmaceuticals, Inc.
    Inventors: Mark A. Reiley, B. Michael Silber, Julio Medina, Frank Kayser, William D. Shrader
  • Publication number: 20150374858
    Abstract: Conjugates derived from non-steroidal anti-inflammatory drugs (NSAIDs) and methods of use thereof are disclosed, useful for, inter alia, identifying and localizing the site of pathology and/or inflammation responsible for the sensation of pain in a patient; for identifying the sites of primary, secondary, benign, or malignant tumors; and for diagnosing infection or confirming or ruling out suspected infection. The NSAID-based conjugates contain an imaging moiety. The conjugates concentrate at sites of increased cyclooxygenase expression, thus revealing the sites of increased prostaglandin production, which is correlated with pain and inflammation, and correlated with tumor presence and/or location. Identifying areas of increased COX expressing can also aid in screening for infections.
    Type: Application
    Filed: June 22, 2015
    Publication date: December 31, 2015
    Inventors: Mark A. REILEY, B. Michael SILBER, Julio MEDINA, Frank KAYSER, William D. SHRADER
  • Patent number: 8450522
    Abstract: The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I or the general formula III: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
    Type: Grant
    Filed: March 4, 2009
    Date of Patent: May 28, 2013
    Assignee: Amgen Inc.
    Inventors: Sean P. Brown, Paul J. Dransfield, Jonathan Houze, Todd J. Kohn, Jiwen Liu, Julio Medina, Vatee Pattaropong, Wang Shen, Marc Vimolratana, Yingcai Wang, Ming Yu, Liusheng Zhu
  • Publication number: 20100298367
    Abstract: The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I or the general formula III: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
    Type: Application
    Filed: March 4, 2009
    Publication date: November 25, 2010
    Inventors: Sean P. Brown, Paul J. Dransfield, Jonathan Houze, Todd J. Kohn, Jiwen Liu, Julio Medina, Vatee Pattaropong, Wang Shen, Marc Vimolratana, Yingcai Wang, Ming Yu, Liusheng Zhu
  • Publication number: 20080085891
    Abstract: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives.
    Type: Application
    Filed: November 26, 2007
    Publication date: April 10, 2008
    Inventors: Zice Fu, Alan Huang, Jiwen Liu, Julio Medina, Michael Schmitt, H. Tang, Yingcai Wang, Qingge Xu
  • Publication number: 20070244155
    Abstract: Compounds having the general formula I and/or the general formula II are useful, for example, for treating metabolic disorders in a subject where the variables are provided herein. Compositions and methods for using the compounds for preparing medicaments and for treating metabolic disorders such as, for instance, type II diabetes are disclosed.
    Type: Application
    Filed: March 13, 2007
    Publication date: October 18, 2007
    Applicant: AMGEN INC.
    Inventors: Rajiv Sharma, Michelle Akerman, Mario Cardozo, Jonathan Houze, An-Rong Li, Jinquian Liu, Jiwen Liu, Zhihua Ma, Julio Medina, Michael Schmitt, Ying Sun, Yingcai Wang, Zhongyu Wang, Liusheng Zhu
  • Publication number: 20070149557
    Abstract: Compounds, compositions and methods are provided that are useful in the treatment of conditions and diseases mediated by a chemokine receptor. In particular, the compounds of the invention modulate the CXCR3 chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes.
    Type: Application
    Filed: November 21, 2006
    Publication date: June 28, 2007
    Applicant: Amgen Inc.
    Inventors: Tassie Collins, Julio Medina, Feng Xu, Liusheng Zhu
  • Publication number: 20070142384
    Abstract: The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formula Q-L1-P-L2-M-X-L3-A wherein the definitions of the variables Q, L1, P, L2, M, X, L3 and A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.
    Type: Application
    Filed: February 24, 2005
    Publication date: June 21, 2007
    Applicant: AMGEN INC.
    Inventors: Michelle Akerman, Jonathan Houze, Daniel Lin, Jinqian Liu, Jiwen Liu, Jian Luo, Zhihua Ma, Julio Medina, Wei Qiu, Jeffrey Reagan, Rajiv Sharma, Michael Schmitt, Stephen Shuttleworth, Ying Sun, Yingcai Wang, Jian Zhang, Liusheng Zhu
  • Publication number: 20070066647
    Abstract: The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables Q, L1, L2, M, X, L3, and A are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
    Type: Application
    Filed: September 8, 2006
    Publication date: March 22, 2007
    Applicant: AMGEN ING.
    Inventors: Michelle Akerman, Sean Brown, Jonathan Houze, Jinqian Liu, Jiwen Liu, Zhihua Ma, Julio Medina, Wei Qiu, Michael Schmitt, Rajiv Sharma, Yingcai Wang, Liusheng Zhu
  • Publication number: 20070015773
    Abstract: Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides aryl nitrile compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis, type I diabetes, asthma, psoriasis and inflammatory bowel disease.
    Type: Application
    Filed: June 26, 2006
    Publication date: January 18, 2007
    Inventors: Philippe Bergeron, Xiaoqi Chen, Xiaohui Du, Jeffrey Deignan, Jason Duquette, Darin Gustin, Julio Medina, Jeffrey Mihalic, George Tonn
  • Publication number: 20060270724
    Abstract: The present invention provides compounds useful, for example, for modulating insulin levels in a subject, having the general formula I: wherein Q is an optionally substituted phenyl; L is a bond or O; P is a benzene or an optionally substituted thiazole ring; and R1 has the values provided herein. The present invention also provides compositions, uses, and methods for use of the compounds, for instance, for treatment of type II diabetes.
    Type: Application
    Filed: May 17, 2006
    Publication date: November 30, 2006
    Applicant: AMGEN INC
    Inventors: Jonathan Houze, Jiwen Liu, Zhihua Ma, Julio Medina, Michael Schmitt, Rajiv Sharma, Ying Sun, Yingcai Wang, Liusheng Zhu
  • Publication number: 20060116388
    Abstract: Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes.
    Type: Application
    Filed: January 13, 2006
    Publication date: June 1, 2006
    Inventors: Julio Medina, Michael Johnson, An-Rong Li, Jiwen Liu, Alan Huang
  • Publication number: 20060069099
    Abstract: Compounds are provided having the formula: wherein variables Ra, R1, R2, R3, R4, A1, A4, L, Q, X and subscript n as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
    Type: Application
    Filed: June 27, 2005
    Publication date: March 30, 2006
    Inventors: Zice Fu, Michael Johnson, An-Rong Li, Andrew Marcus, Julio Medina, Philippe Bergeron, Xiaoqi Chen, Xiaohui Du, Jeffrey Deignan, Jason Duquette, Darin Gustin, Jeffrey Mihalic
  • Publication number: 20060069106
    Abstract: Compounds are provided having the formula: wherein variables A1, A2, A3, A4, R1, R2, R3, R4, Q and L are as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
    Type: Application
    Filed: June 27, 2005
    Publication date: March 30, 2006
    Inventors: Zice Fu, Michael Johnson, An-Rong Li, Andrew Marcus, Julio Medina, Philippe Bergeron, Xiaoqi Chen, Xiaohui Du, Jeffrey Deignan, Jason Duquette, Darin Gustin, Jeffrey Mihalic
  • Publication number: 20060069127
    Abstract: Compounds are provided having the formula: wherein variables R0, R1, R2, R3, R4, Q, L and subscript n are as described herein. The subject compounds are useful for treatment of infammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
    Type: Application
    Filed: June 27, 2005
    Publication date: March 30, 2006
    Inventors: Zice Fu, Michael Johnson, An-Rong Li, Andrew Marcus, Julio Medina, Philippe Bergeron, Xiaoqi Chen, Xiaohui Du, Jeffrey Deignan, Jason Duquette, Darin Gustin, Jeffrey Mihalic
  • Publication number: 20060004012
    Abstract: The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formula Q-L1-P-L2-M-X-L3-A wherein the definitions of the variables Q, L1, P, L2, M, X, L3 and A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.
    Type: Application
    Filed: February 25, 2005
    Publication date: January 5, 2006
    Inventors: Michelle Akerman, Jonathan Houze, Daniel Lin, Jiwen Liu, Jian Luo, Julio Medina, Wei Qiu, Jeffrey Reagan, Rajiv Sharma, Michael Schmitt, Stephen Shuttleworth, Ying Sun, Yingcai Wang, Jian Zhang, Liusheng Zhu
  • Publication number: 20050101540
    Abstract: The present invention provides compounds, compositions and methods for the inhibition or treatment of conditions or disorders modulated by the STAT transcription factors, particularly STAT4 and STAT6. Additionally, the compounds are useful for the diagnosis of conditions dependent on STAT signaling.
    Type: Application
    Filed: December 14, 2004
    Publication date: May 12, 2005
    Applicant: Amgen Inc.
    Inventors: Alan Huang, Jiwen Liu, Julio Medina, Xuemei Wang, Feng Xu, Liusheng Zhu
  • Patent number: 6884782
    Abstract: The present invention provides compounds, compositions and methods for the inhibition or treatment of conditions or disorders modulated by the STAT transcription factors, particularly STAT4 and STAT6. Additionally, the compounds are useful for the diagnosis of conditions dependent on STAT signaling.
    Type: Grant
    Filed: November 7, 2001
    Date of Patent: April 26, 2005
    Assignee: Amgen Inc.
    Inventors: Alan Huang, Jiwen Liu, Julio Medina, Xuemei Wang, Feng Xu, Liusheng Zhu