Patents by Inventor Julio Mulero

Julio Mulero has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SE33 mutations impacting genotype concordance
    Patent number: 11913066
    Abstract: Disclosed are primer set compositions, methods and kits for human identification using the highly complex sequence locus, SE33 (ACTBP2) in single and multiplex PCR reactions. Additionally, disclosed are three newly discovered single nucleotide polymorphisms (SNPs) within the SE33 locus that can cause discordance seen as mobility shift or allelic dropout. Also disclosed are kits useful in human identification.
    Type: Grant
    Filed: January 26, 2022
    Date of Patent: February 27, 2024
    Assignee: Life Technologies Corporation
    Inventors: Robert Green, Dennis Wang, Julio Mulero, Robert Lagace
  • SE33 MUTATIONS IMPACTING GENOTYPE CONCORDANCE
    Publication number: 20220205023
    Abstract: Disclosed are primer set compositions, methods and kits for human identification using the highly complex sequence locus, SE33 (ACTBP2) in single and multiplex PCR reactions. Additionally, disclosed are three newly discovered single nucleotide polymorphisms (SNPs) within the SE33 locus that can cause discordance seen as mobility shift or allelic dropout. Also disclosed are kits useful in human identification.
    Type: Application
    Filed: January 26, 2022
    Publication date: June 30, 2022
    Inventors: Robert GREEN, Dennis WANG, Julio MULERO, Robert LAGACE
  • Mesylate based master mix
    Patent number: 11293059
    Abstract: Disclosed herein are mesylate containing compositions, methods of use of such compositions and kits of components encompassing such compositions for improving the amplification of nucleic acids, especially in the presence of enzymatic inhibitors. These find particular use in forensic and environmental analyses. The instant disclosure provides new compositions, methods and kits of components for overcoming PCR inhibition. In some embodiments disclosed herein is a PCR master mix, the PCR master mix encompassing a mesylate.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: April 5, 2022
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Chang Zhong, Julio Mulero, Steven Menchen
  • SE33 mutations impacting genotype concordance
    Patent number: 11248256
    Abstract: Disclosed are primer set compositions, methods and kits for human identification using the highly complex sequence locus, SE33 (ACTBP2) in single and multiplex PCR reactions. Additionally, disclosed are three newly discovered single nucleotide polymorphisms (SNPs) within the SE33 locus that can cause discordance seen as mobility shift or allelic dropout. Also disclosed are kits useful in human identification.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: February 15, 2022
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Robert Green, Dennis Wang, Julio Mulero, Robert Lagace
  • MULTIPLEX Y-STR ANALYSIS
    Publication number: 20200255892
    Abstract: Novel Y-STR multiplex analysis designs, primer design, allelic ladders, methods of use and kits are disclosed, including the use of primer sets designed to provide amplicons for at least 11 Y-STR loci having a base pair size of less than about 220 bp, as well as the use of primer sets designed to provide amplicons for at least 22 Y-STR loci including at least 5 rapidly mutating loci.
    Type: Application
    Filed: February 24, 2020
    Publication date: August 13, 2020
    Inventors: Christina Bormann Chung, Julio Mulero, Lori Hennessy
  • MESYLATE BASED MASTER MIX
    Publication number: 20200199652
    Abstract: Disclosed herein are mesylate containing compositions, methods of use of such compositions and kits of components encompassing such compositions for improving the amplification of nucleic acids, especially in the presence of enzymatic inhibitors. These find particular use in forensic and environmental analyses. The instant disclosure provides new compositions, methods and kits of components for overcoming PCR inhibition. In some embodiments disclosed herein is a PCR master mix, the PCR master mix encompassing a mesylate.
    Type: Application
    Filed: June 20, 2018
    Publication date: June 25, 2020
    Inventors: Chang ZHONG, Julio MULERO, Steven MENCHEN
  • Multiplex Y-STR analysis
    Patent number: 10597707
    Abstract: Novel Y-STR multiplex analysis designs, primer design, allelic ladders, methods of use and kits are disclosed, including the use of primer sets designed to provide amplicons for at least 11 Y-STR loci having a base pair size of less than about 220 bp, as well as the use of primer sets designed to provide amplicons for at least 22 Y-STR loci including at least 5 rapidly mutating loci.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: March 24, 2020
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Christina Bormann Chung, Julio Mulero, Lori Hennessy
  • SE33 MUTATIONS IMPACTING GENOTYPE CONCORDANCE
    Publication number: 20170335377
    Abstract: Disclosed are primer set compositions, methods and kits for human identification using the highly complex sequence locus, SE33 (ACTBP2) in single and multiplex PCR reactions. Additionally, disclosed are three newly discovered single nucleotide polymorphisms (SNPs) within the SE33 locus that can cause discordance seen as mobility shift or allelic dropout. Also disclosed are kits useful in human identification.
    Type: Application
    Filed: June 5, 2017
    Publication date: November 23, 2017
    Inventors: ROBERT GREEN, DENNIS WANG, JULIO MULERO, ROBERT LAGACE
  • MULTIPLEX Y-STR ANALYSIS
    Publication number: 20160053311
    Abstract: Novel Y-STR multiplex analysis designs, primer design, allelic ladders, methods of use and kits are disclosed, including the use of primer sets designed to provide amplicons for at least 11 Y-STR loci having a base pair size of less than about 220 bp, as well as the use of primer sets designed to provide amplicons for at least 22 Y-STR loci including at least 5 rapidly mutating loci.
    Type: Application
    Filed: June 1, 2015
    Publication date: February 25, 2016
    Inventors: Christina BORMANN CHUNG, Julio Mulero, Lori Hennessy
  • Human single nucleotide polymorphisms
    Patent number: 9260757
    Abstract: Disclosed are methods for human identification utilizing newly discovered single nucleotide polymorphisms (SNPs) within CODIS loci which can cause allelic dropout. Also disclosed are kits useful in human identification.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: February 16, 2016
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Julio Mulero, Michael Malicdem, Robert Lagace
  • SE33 MUTATIONS IMPACTING GENOTYPE CONCORDANCE
    Publication number: 20160010146
    Abstract: Disclosed are primer set compositions, methods and kits for human identification using the highly complex sequence locus, SE33 (ACTBP2) in single and multiplex PCR reactions. Additionally, disclosed are three newly discovered single nucleotide polymorphisms (SNPs) within the SE33 locus that can cause discordance seen as mobility shift or allelic dropout. Also disclosed are kits useful in human identification.
    Type: Application
    Filed: July 27, 2015
    Publication date: January 14, 2016
    Inventors: Robert GREEN, Dennis Wang, Julio Mulero, Robert Lagace
  • NOVEL HUMAN SINGLE NUCLEOTIDE POLYMORPHISMS
    Publication number: 20150322522
    Abstract: Disclosed are methods for human identification utilizing newly discovered single nucleotide polymorphisms (SNPs) within CODIS loci which can cause allelic dropout. Also disclosed are kits useful in human identification.
    Type: Application
    Filed: May 11, 2015
    Publication date: November 12, 2015
    Inventors: Julio MULERO, Michael Malicdem, Robert Lagace
  • SE33 mutations impacting genotype concordance
    Patent number: 9090946
    Abstract: Disclosed are primer set compositions, methods and kits for human identification using the highly complex sequence locus, SE33 (ACTBP2) in single and multiplex PCR reactions. Additionally, disclosed are three newly discovered single nucleotide polymorphisms (SNPs) within the SE33 locus that can cause discordance seen as mobility shift or allelic dropout. Also disclosed are kits useful in human identification.
    Type: Grant
    Filed: September 21, 2011
    Date of Patent: July 28, 2015
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Robert Green, Dennis Wang, Julio Mulero, Robert Lagace
  • Human single nucleotide polymorphisms within CODIS loci D13S317, TH01, vWA, D12S391, and D6S1043
    Patent number: 9029088
    Abstract: Disclosed are methods for human identification utilizing newly discovered single nucleotide polymorphisms (SNPs) within CODIS loci D13S317, TH01, vWA, D12S391 and D6S1043, which can cause allelic dropout. Also disclosed are kits useful in human identification.
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: May 12, 2015
    Assignee: Life Technologies Corporation
    Inventors: Julio Mulero, Michael Malicdem, Robert Lagace
  • Amelogenin SNP on chromosome X
    Patent number: 8637655
    Abstract: Disclosed are methods for gender determination in the intron 1 region of the amelogenin locus and a newly discovered single nucleotide polymorphism (SNP) within the X chromosome of the amelogenin locus which can cause allelic dropout. Also disclosed are kits useful in gender determination.
    Type: Grant
    Filed: August 13, 2010
    Date of Patent: January 28, 2014
    Assignee: Life Technologies Corporation
    Inventors: Julio Mulero, Robert Green, Robert Lagace, Lori Hennessy
  • Allelic ladder loci
    Patent number: 8409806
    Abstract: Disclosed are rare short tandem repeat (STR) alleles within the D10S1248 and D12S391 loci in humans. Provided are representative allelic ladders for each locus, methods and assays using these alleles and kits containing allelic ladders comprising these alleles for accurate genotyping and identification of a wide range of individuals.
    Type: Grant
    Filed: November 24, 2010
    Date of Patent: April 2, 2013
    Assignee: Life Technologies Corporation
    Inventors: Robert Green, Julio Mulero, Lori Hennessy, Robert Lagace, Chien-Wei Chang
  • SE33 MUTATIONS IMPACTING GENOTYPE CONCORDANCE
    Publication number: 20120070832
    Abstract: Disclosed are primer set compositions, methods and kits for human identification using the highly complex sequence locus, SE33 (ACTBP2) in single and multiplex PCR reactions. Additionally, disclosed are three newly discovered single nucleotide polymorphisms (SNPs) within the SE33 locus that can cause discordance seen as mobility shift or allelic dropout. Also disclosed are kits useful in human identification.
    Type: Application
    Filed: September 21, 2011
    Publication date: March 22, 2012
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Robert GREEN, Dennis Wang, Julio Mulero, Robert Lagace
  • Amelogenin SNP on Chromosome X
    Publication number: 20110237443
    Abstract: Disclosed are methods for gender determination in the intron 1 region of the amelogenin locus and a newly discovered single nucleotide polymorphism (SNP) within the X chromosome of the amelogenin locus which can cause allelic dropout. Also disclosed are kits useful in gender determination.
    Type: Application
    Filed: August 13, 2010
    Publication date: September 29, 2011
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Julio Mulero, Robert Green, Robert Lagace, Lori Hennessy
  • NOVEL HUMAN SINGLE NUCLEOTIDE POLYMORPHISMS
    Publication number: 20110183857
    Abstract: Disclosed are methods for human identification utilizing newly discovered single nucleotide polymorphisms (SNPs) within CODIS loci which can cause allelic dropout. Also disclosed are kits useful in human identification.
    Type: Application
    Filed: October 15, 2010
    Publication date: July 28, 2011
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Julio Mulero, Michael Malicdem, Robert Lagace
  • Allelic ladder loci
    Publication number: 20110171654
    Abstract: Disclosed are rare short tandem repeat (STR) alleles within the D10S1248 and D12S391 loci in humans. Provided are representative allelic ladders for each locus, methods and assays using these alleles and kits containing allelic ladders comprising these alleles for accurate genotyping and identification of a wide range of individuals.
    Type: Application
    Filed: November 24, 2010
    Publication date: July 14, 2011
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Robert Green, Julio Mulero, Lori Hennessy, Robert Lagace, Chien-Wei Chang