Patents by Inventor Julio Perez

Julio Perez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystal forms of (R)-N-methylnaltrexone bromide and uses thereof
    Patent number: 9102680
    Abstract: The present invention provides a new forms of (R)—N-methylnaltrexone, and compositions thereof, useful as a peripheral mu opioid receptor antagonist.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: August 11, 2015
    Assignees: Wyeth LLC, Progenics Pharmamceuticals, Inc.
    Inventors: Valeriya N. Smolenskaya, Kadum A. Al Shareffi, Julio Perez, Syed M. Shah, Thomas A. Boyd
  • SYNTHESIS OF (R)-N-METHYLNALTREXONE
    Publication number: 20150057303
    Abstract: This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.
    Type: Application
    Filed: March 18, 2014
    Publication date: February 26, 2015
    Applicant: PROGENICS PHARMACEUTICALS, INC.
    Inventors: Harold D. Doshan, Julio Perez
  • Preparation and use of (R),(R)-2,2?-bis-methylnaltrexone
    Patent number: 8916706
    Abstract: This invention relates to synthesis of (R),(R)-2,2?-bis-MNTX, as shown in Formula (I), and related methods and products.
    Type: Grant
    Filed: June 6, 2013
    Date of Patent: December 23, 2014
    Assignee: Progenics Pharmaceuticals, Inc.
    Inventors: Alfred A. Avey, Julio Perez
  • Peripheral opioid receptor antagonists and uses thereof
    Patent number: 8853232
    Abstract: The present invention provides a compound of formula I: wherein R1, R2, R2? and X? are as defined and described herein, methods of manufacture thereof and compositions thereof, useful for example as peripheral mu opioid receptor antagonists in treatment of side effects of opioid administration.
    Type: Grant
    Filed: September 4, 2013
    Date of Patent: October 7, 2014
    Assignees: Wyeth LLC, Progenics Pharmaceuticals., Inc.
    Inventors: Alfred A. Avey, Appavu Chandrasekaren, Harold D. Doshan, Julio Perez, Yakov Rotshteyn
  • PERIPHERAL OPIOID RECEPTOR ANTAGONISTS AND USES THEREOF
    Publication number: 20140142132
    Abstract: The present invention provides a compound of formula I: wherein R1, R2, R2? and X? are as defined and described herein, methods of manufacture thereof and compositions thereof, useful for example as peripheral mu opioid receptor antagonists in treatment of side effects of opioid administration.
    Type: Application
    Filed: September 4, 2013
    Publication date: May 22, 2014
    Applicants: WYETH, LLC, PROGENICS PHARMACEUTICALS, INC.
    Inventors: Alfred A. Avey, Appavu Chandrasekaren, Harold D. Doshan, Julio Perez, Yakov Rotshteyn
  • PREPARATION AND USE OF (R),(R)-2,2'-BIS-METHYLNALTREXONE
    Publication number: 20130296570
    Abstract: This invention relates to synthesis of (R),(R)-2,2?-bis-MNTX, as shown in Formula (I), and related methods and products.
    Type: Application
    Filed: June 6, 2013
    Publication date: November 7, 2013
    Inventors: Alfred A. Avey, Julio Perez
  • Peripheral opioid receptor antagonists and uses thereof
    Patent number: 8546418
    Abstract: The present invention provides a compound of formula I: wherein R1, R2, R2? and X? are as defined and described herein, methods of manufacture thereof and compositions thereof, useful for example as peripheral mu opioid receptor antagonists in treatment of side effects of opioid administration.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: October 1, 2013
    Assignees: Progenics Pharmaceuticals, Inc., Wyeth, LLC
    Inventors: Alfred A. Avey, Appavu Chandrasekaren, Harold D. Doshan, Julio Perez, Yakov Rotshteyn
  • Preparation and use of (R),(R)-2,2?-bis-methylnaltrexone
    Patent number: 8471022
    Abstract: This invention relates to the synthesis of (R),(R)-2,2?-bis-MNTX, as shown in Formula (I), and related methods and products.
    Type: Grant
    Filed: February 6, 2008
    Date of Patent: June 25, 2013
    Assignee: Progenics Pharmaceuticals, Inc.
    Inventors: Alfred A. Avey, Julio Perez
  • Synthesis of -methylnaltrexone
    Patent number: 8343992
    Abstract: This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.
    Type: Grant
    Filed: January 22, 2010
    Date of Patent: January 1, 2013
    Assignee: Progenics Pharmaceuticals, Inc.
    Inventors: Harold D. Doshan, Julio Perez
  • PERIPHERAL OPIOID RECEPTOR ANTAGONISTS AND USES THEREOF
    Publication number: 20110190331
    Abstract: The present invention provides a compound of formula I: wherein R1, R2, R2? and X? are as defined and described herein, methods of manufacture thereof and compositions thereof, useful for example as peripheral mu opioid receptor antagonists in treatment of side effects of opioid administration.
    Type: Application
    Filed: March 28, 2008
    Publication date: August 4, 2011
    Inventors: Alfred A. Avey, Appavu Chandrasekaren, Harold D. Doshan, Julio Perez, Yakov Rotshteyn
  • PREPARATION AND USE OF (R),(R)-2,2'-BIS-METHYLNALTREXONE
    Publication number: 20110100099
    Abstract: This invention relates to synthesis of (R),(R)-2,2?-bis-MNTX, as shown in Formula (I), and related methods and products.
    Type: Application
    Filed: February 6, 2008
    Publication date: May 5, 2011
    Applicant: Progenics Pharmaceuticals, Inc.
    Inventors: Alfred A. Avey, Julio Perez
  • SYNTHESIS OF R-N-METHYLNALTREXONE
    Publication number: 20100311781
    Abstract: This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.
    Type: Application
    Filed: January 22, 2010
    Publication date: December 9, 2010
    Inventors: Harold D. Doshan, Julio Perez
  • CRYSTAL FORMS OF (R)-N-METHYLNALTREXONE BROMIDE AND USES THEREOF
    Publication number: 20100305323
    Abstract: The present invention provides a new forms of (R)—N-methylnaltrexone, and compositions thereof, useful as a peripheral mu opioid receptor antagonist.
    Type: Application
    Filed: March 28, 2008
    Publication date: December 2, 2010
    Inventors: Valeriya N. Smolenskaya, Kadum A. Al Shareffi, Julio Perez, Syed M. Shah, Thomas A. Boyd
  • Synthesis of R-N-methylnaltrexone
    Patent number: 7674904
    Abstract: This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.
    Type: Grant
    Filed: May 25, 2006
    Date of Patent: March 9, 2010
    Assignee: Progenics Pharmaceuticals, Inc.
    Inventors: Harold D. Doshan, Julio Perez
  • (R)-N-Stereoisomers of 7,8-Saturated-4,5-Epoxy-Morphinanium Analogs
    Publication number: 20090047279
    Abstract: Novel (R)—N-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium analogs are disclosed. Pharmaceutical compositions containing the (R)—N-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium analogs and methods for their pharmaceutical uses are also disclosed. Such analogs are disclosed as being useful in treating, among varying conditions, opioid-induced constipation.
    Type: Application
    Filed: November 21, 2007
    Publication date: February 19, 2009
    Applicant: Progenics Pharmaceuticals, Inc.
    Inventors: Julio Perez, Amy Qi Han, Yakov Rotshteyn
  • N-Oxides of 4,5-Epoxy-Morphinanium Analogs
    Publication number: 20080234306
    Abstract: Novel N-oxides of 4,5-epoxy-morphinanium analogs are disclosed. Pharmaceutical compositions containing the N-oxides of 4,5-epoxy-morphinanium analogs and methods of their pharmaceutical uses are also disclosed. The compounds disclosed are useful, inter alia, as modulators of opioid receptors.
    Type: Application
    Filed: November 21, 2007
    Publication date: September 25, 2008
    Applicant: Progenics Pharmaceuticals, Inc.
    Inventors: Julio Perez, Amy Qi Han, Yakov Rotshteyn, Govindaraj Kumaran
  • (S)-N-Stereoisomers of 7,8-Saturated-4,5-Epoxy-Morphinanium Analogs
    Publication number: 20080207669
    Abstract: Novel (S)-N-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium analogs are disclosed. Pharmaceutical compositions containing the (S)-N-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium analogs and methods for their pharmaceutical uses are also disclosed. Such analogs are disclosed as being useful in treating, among varying conditions, hypermotility of the gastrointestinal tract.
    Type: Application
    Filed: November 21, 2007
    Publication date: August 28, 2008
    Applicant: Progenics Pharmaceuticals, Inc.
    Inventors: Julio Perez, Amy Qi Han, Yakov Rotshteyn
  • 7,8-Saturated-4,5-Epoxy-Morphinanium Analogs
    Publication number: 20080176884
    Abstract: Novel 7,8-saturated-4,5-epoxy-morphinanium analogs are disclosed. Pharmaceutical compositions containing the 7,8-saturated-4,5-epoxy-morphinanium analogs and methods of their pharmaceutical uses are also disclosed. The compounds disclosed are useful, inter alia, as modulators of opioid receptors.
    Type: Application
    Filed: November 21, 2007
    Publication date: July 24, 2008
    Applicant: Progenics Pharmaceuticals, Inc.
    Inventors: Julio Perez, Amy Qi Han, Yakov Rotshteyn
  • Processes for Synthesizing Quaternary 4,5-Epoxy-Morphinan Analogs and Isolating their N-Stereoisomers
    Publication number: 20080161570
    Abstract: Methods for the synthesis of 4,5-epoxy-morphinaniums using dimethyl formamide and resolution of the diastereomeric products by means of HPLC.
    Type: Application
    Filed: November 19, 2007
    Publication date: July 3, 2008
    Applicant: Progenerics Pharmaceuticals, Inc.
    Inventors: Julio Perez, Amy Qi Han, Alfred A. Avey
  • Synthesis of R-N-methylnaltrexone
    Publication number: 20070099946
    Abstract: This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.
    Type: Application
    Filed: May 25, 2006
    Publication date: May 3, 2007
    Inventors: Harold Doshan, Julio Perez