Patents by Inventor Julio Spinelli

Julio Spinelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8639334
    Abstract: Response to cardiac resynchronization therapy is predicted for a given stimulation site so that an atrioventricular delay of an implantable device administering cardiac resynchronization therapy may be set to a proper amount. The first deflection of ventricular depolarization is measured, such as through a surface electrocardiogram or through an intracardiac electrogram measured by a lead positioned in the heart at the stimulation site. The maximum deflection of the ventricular depolarization is then measured by the lead positioned at the stimulation site. The interval of time between the first deflection and the maximum deflection of the ventricular depolarization is compared to a threshold to determine whether the stimulation site is a responder site. If the interval is larger than the threshold, then the site is a responder and the atrioventricular delay of the implantable device may be set to less than the intrinsic atrioventricular delay of the patient.
    Type: Grant
    Filed: November 22, 2006
    Date of Patent: January 28, 2014
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Julio Spinelli, Yinghong Yu
  • Publication number: 20130013018
    Abstract: Methods and systems are disclosed for determining whether a patient is a responder to cardiac resynchronization therapy. The beginning and ending of the intrinsic ventricular depolarization are determined through signals measured from one or more electrodes implanted in the patient's heart. An interval between the beginning and ending of the intrinsic ventricular depolarization is computed and is compared to a threshold. The threshold may be determined empirically. The pacing parameters of a heart stimulation device, such as a pacemaker, may then be configured, for example, by setting the paced atrio-ventricular delay based on whether the patient responds positively to cardiac resynchronization therapy.
    Type: Application
    Filed: September 13, 2012
    Publication date: January 10, 2013
    Inventors: Jiang Ding, Yinghong Yu, Julio Spinelli
  • Patent number: 8352027
    Abstract: A cardiac rhythm management system for providing a plurality of therapy modalities. For example, the system may include a cardiac resynchronization therapy module for providing cardiac resynchronization therapy and a pacemaker module for providing bradycardia therapy, as well as a selector module coupled to the cardiac resynchronization therapy module and the bradycardia module. The selector module may select an operating mode from among a plurality of operating modes including the cardiac resynchronization therapy module and the pacemaker module. Various manual and automatic methods may be used to select the operating mode. In addition, a reversion management system may be included to assist the cardiac rhythm management system to recover in case of a disruption to the system.
    Type: Grant
    Filed: March 13, 2008
    Date of Patent: January 8, 2013
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Julio Spinelli, Qingsheng Zhu, Bruce H. Kenknight, Yinghong Yu, Jiang Ding
  • Publication number: 20120238889
    Abstract: Systems and methods for determining the coronary sinus vein branch location of a left ventricle electrode are disclosed. The systems and methods involve detecting the occurrence of electrical events within the patient's heart including sensing one or more of the electrical events with the electrode and then analyzing the electrical events to determine the electrode's position. The determination of electrode position may be used to automatically adjust operating parameters of a VRT device. Furthermore, the determination of electrode position may be made in real-time during installation of the electrode and a visual indication of the electrode position may be provided on a display screen.
    Type: Application
    Filed: June 4, 2012
    Publication date: September 20, 2012
    Inventors: Yinghong Yu, Jiang Ding, Jeng Mah, Julio Spinelli
  • Patent number: 8170652
    Abstract: A method and apparatus for predicting acute response to cardiac resynchronization therapy is disclosed. The method can comprise measuring a first interval during an intrinsic systolic cycle and measuring a second interval during a stimulated systolic cycle. The acute response can be predicted by comparing the percent change in duration between the first interval and the second interval against a pre-determined threshold value. The first and second time intervals can be measured using, for example, a surface ECG or, alternatively, an intracardiac electrogram. In one embodiment, the first interval can be the duration of an intrinsic QRS complex measured during a non-stimulated systolic cycle. Similarly, the second interval can be the duration of a stimulated QRS complex measured during a stimulated systolic cycle.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: May 1, 2012
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Yinghong Yu, Jiang Ding, Julio Spinelli, Angelo Auricchio
  • Patent number: 7953486
    Abstract: A maximum pacing rate limiter for use in adaptive rate pacing in conjunction with a cardiac rhythm management system for a heart. The maximum pacing rate limiter may function to measure an interval, termed the ERT interval, between a paced ventricular evoked response and a T-wave. The maximum pacing rate limiter may further function to maintain the ERT interval at less than a certain percentage of the total cardiac cycle. In one disclosed embodiment, a maximum pacing rate limiter calculates an ERT rate based on the detected paced ventricular evoked response and the T-wave, and the pacing rate limiter module further communicates the minimum of the ERT rate and an adaptive-rate sensor indicated rate to a pacemaker.
    Type: Grant
    Filed: September 13, 2005
    Date of Patent: May 31, 2011
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Douglas R. Daum, Geng Zhang, Qingsheng Zhu, Gerrard M. Carlson, Julio Spinelli
  • Publication number: 20110092836
    Abstract: Systems and methods for determining the coronary sinus vein branch location of a left ventricle electrode are disclosed. The systems and methods involve detecting the occurrence of electrical events within the patient's heart including sensing one or more of the electrical events with the electrode and then analyzing the electrical events to determine the electrode's position. The determination of electrode position may be used to automatically adjust operating parameters of a VRT device. Furthermore, the determination of electrode position may be made in real-time during installation of the electrode and a visual indication of the electrode position may be provided on a display screen.
    Type: Application
    Filed: December 22, 2010
    Publication date: April 21, 2011
    Inventors: Yinghong Yu, Jiang Ding, Jeng Mah, Julio Spinelli
  • Publication number: 20110071588
    Abstract: A pacing system for providing optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.
    Type: Application
    Filed: November 29, 2010
    Publication date: March 24, 2011
    Inventors: Jiang Ding, Yinghong Yu, Andrew P. Kramer, Julio Spinelli
  • Patent number: 7881794
    Abstract: Systems and methods for determining the coronary sinus vein branch location of a left ventricle electrode are disclosed. The systems and methods involve detecting the occurrence of electrical events within the patient's heart including sensing one or more of the electrical events with the electrode and then analyzing the electrical events to determine the electrode's position. The determination of electrode position may be used to automatically adjust operating parameters of a VRT device. Furthermore, the determination of electrode position may be made in real-time during installation of the electrode and a visual indication of the electrode position may be provided on a display screen.
    Type: Grant
    Filed: August 6, 2007
    Date of Patent: February 1, 2011
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Yinghong Yu, Jiang Ding, Jeng Mah, Julio Spinelli
  • Patent number: 7856270
    Abstract: A pacing system for providing optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.
    Type: Grant
    Filed: February 2, 2005
    Date of Patent: December 21, 2010
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Jiang Ding, Yinghong Yu, Andrew P. Kramer, Julio Spinelli
  • Publication number: 20090131775
    Abstract: An implanted heart monitor includes sensors that measure various aspects of the heart failure patient's heart. A remote heart monitoring system connects the implanted heart monitor to a care provider, such as a physician. The data provided by the implanted heart monitor permits the care provider to obtain valuable data on the heart in order to make health care decisions affecting the heart failure patient's treatment. In many cases, the measurement of core body temperature and other patient data will enable the care provider to alter the patient's treatment to address the patient's condition. The implanted heart monitor can communicate over a wireless communication link with an external monitor. The implanted heart monitor may be implemented as part of a pacing device (i.e., pace maker) or may be a separate unit devoted to monitoring functions. The external monitor communicates with a monitoring station over a communication link.
    Type: Application
    Filed: January 12, 2009
    Publication date: May 21, 2009
    Inventors: Qingsheng Zhu, Julio Spinelli
  • Patent number: 7479107
    Abstract: An implanted heart monitor includes sensors that measure various aspects of the heart failure patient's heart. A remote heart monitoring system connects the implanted heart monitor to a care provider, such as a physician. The data provided by the implanted heart monitor permits the care provider to obtain valuable data on the heart in order to make health care decisions affecting the heart failure patient's treatment. In many cases, the measurement of core body temperature and other patient data will enable the care provider to alter the patient's treatment to address the patient's condition. The implanted heart monitor can communicate over a wireless communication link with an external monitor. The implanted heart monitor may be implemented as part of a pacing device (i.e., pace maker) or may be a separate unit devoted to monitoring functions. The external monitor communicates with a monitoring station over a communication link.
    Type: Grant
    Filed: October 25, 2005
    Date of Patent: January 20, 2009
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Qingsheng Zhu, Julio Spinelli
  • Publication number: 20080306568
    Abstract: Methods and systems are disclosed for determining whether a patient is a responder to cardiac resynchronization therapy. The beginning and ending of the intrinsic ventricular depolarization are determined through signals measured from one or more electrodes implanted in the patient's heart. An interval between the beginning and ending of the intrinsic ventricular depolarization is computed and is compared to a threshold. The threshold may be determined empirically. The pacing parameters of a heart stimulation device, such as a pacemaker, may then be configured, for example, by setting the paced atrio-ventricular delay based on whether the patient responds positively to cardiac resynchronization therapy.
    Type: Application
    Filed: August 5, 2008
    Publication date: December 11, 2008
    Applicant: Cardiac Pacemakers, Inc.
    Inventors: Jing Ding, Yinghong Yu, Julio Spinelli
  • Patent number: 7424324
    Abstract: Methods and systems are disclosed for determining whether a patient is a responder to cardiac resynchronization therapy. The beginning and ending of the intrinsic ventricular depolarization are determined through signals measured from one or more electrodes implanted in the patient's heart. An interval between the beginning and ending of the intrinsic ventricular depolarization is computed and is compared to a threshold. The threshold may be determined empirically. The pacing parameters of a heart stimulation device, such as a pacemaker, may then be configured, for example, by setting the paced atrio-ventricular delay based on whether the patient responds positively to cardiac resynchronization therapy.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: September 9, 2008
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Jiang Ding, Yinghong Yu, Julio Spinelli
  • Publication number: 20080114410
    Abstract: This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.
    Type: Application
    Filed: January 18, 2008
    Publication date: May 15, 2008
    Inventors: Jiang Ding, Julio Spinelli, Yinghong Yu, Jeffrey Stahmann
  • Publication number: 20080097538
    Abstract: A cardiac electro-stimulatory device and method for operating same in which stimulation pulses are distributed among a plurality of electrodes fixed at different sites of the myocardium in order to reduce myocardial hypertrophy brought about by repeated pacing at a single site and/or increase myocardial contractility. In order to spatially and temporally distribute the stimulation, the pulses are delivered through a switchable pulse output configuration during a single cardiac cycle, with each configuration comprising one or more electrodes fixed to different sites in the myocardium.
    Type: Application
    Filed: October 31, 2007
    Publication date: April 24, 2008
    Applicant: Cardiac Pacemakers, Inc.
    Inventors: Rodney Salo, Julio Spinelli, Bruce KenKnight
  • Publication number: 20080097541
    Abstract: A cardiac electro-stimulatory device and method for operating same in which stimulation pulses are distributed among a plurality of electrodes fixed at different sites of the myocardium in order to reduce myocardial hypertrophy brought about by repeated pacing at a single site and/or increase myocardial contractility. In order to spatially and temporally distribute the stimulation, the pulses are delivered through a switchable pulse output configuration during a single cardiac cycle, with each configuration comprising one or more electrodes fixed to different sites in the myocardium.
    Type: Application
    Filed: October 31, 2007
    Publication date: April 24, 2008
    Applicant: Cardiac Pacemakers, Inc.
    Inventors: Rodney Salo, Julio Spinelli, Bruce KenKnight
  • Publication number: 20080097542
    Abstract: A method and apparatus for predicting acute response to cardiac resynchronization therapy is disclosed. The method can comprise measuring a first interval during an intrinsic systolic cycle and measuring a second interval during a stimulated systolic cycle. The acute response can be predicted by comparing the percent change in duration between the first interval and the second interval against a pre-determined threshold value. The first and second time intervals can be measured using, for example, a surface ECG or, alternatively, an intracardiac electrogram. In one embodiment, the first interval can be the duration of an intrinsic QRS complex measured during a non-stimulated systolic cycle. Similarly, the second interval can be the duration of a stimulated QRS complex measured during a stimulated systolic cycle.
    Type: Application
    Filed: December 21, 2007
    Publication date: April 24, 2008
    Inventors: Yinghong Yu, Jiang Ding, Julio Spinelli, Angelo Auricchio
  • Publication number: 20080091138
    Abstract: A drug delivery system detects a cardiac condition indicative of a need for increasing a cardiac metabolic level and, in response, releases a drug into tissue or blood to shift a source of metabolically synthesized energy fueling cardiac contraction from fatty acid to glucose. One example of such a system includes an implantable device detecting an ischemia and a transdermal drug delivery device delivering a drug when an ischemic condition is detected. Another example of such a system includes one or more implantable devices detecting a predefined change in cardiac metabolic level and delivering a drug when the change is detected. Such systems are applied to treat, for example, patients suffering ischemia and/or heart failure and patients having suffered myocardial infarction.
    Type: Application
    Filed: December 3, 2007
    Publication date: April 17, 2008
    Applicant: Cardiac Pacemakers, Inc.
    Inventors: Joseph Pastore, Julio Spinelli, Helen Reeve, Jeffrey Ross, Rodney Salo, Allan Shuros
  • Publication number: 20080077031
    Abstract: One embodiment includes a system for prescribing therapeutic treatment for a patient via communications over a network, including an implantable medical device (IMD) to be implanted in the patient to record a patient characteristic, the implantable medical device being programmable and configured to communicate via wireless communications with the IMD and to communicate securely over the network, the medical device programming computer including a user interface. The embodiment includes a server to communicate securely over the network with the medical device programming computer, the server including at least a first expert prescription system comprising at least one physician's prescription and at least one expert-system to compare the at least one patient characteristic to the at least one physician's prescription to issue a parameter to be programmed into the IMD based on the comparison.
    Type: Application
    Filed: November 19, 2007
    Publication date: March 27, 2008
    Applicant: Cardiac Pacemakers, Inc.
    Inventors: Julio Spinelli, Qingsheng Zhu