Patents by Inventor Julita S. Imperial

Julita S. Imperial has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • J-superfamily conotoxin peptides
    Patent number: 9062118
    Abstract: The invention relates to relatively short peptides (termed J-Superfamily conotoxin peptides, J-conotoxins or J-conotoxin peptides herein), about 25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. The J-conotoxins are useful for treating disorders involving voltage gated ion channels and/or receptors.
    Type: Grant
    Filed: June 6, 2007
    Date of Patent: June 23, 2015
    Assignees: University of Utah Research Foundation, The University of Queensland, Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
    Inventors: Julita S. Imperial, Baldomero M. Olivera, Paul F. Alewood, Heinz Terlau, David J. Craik, Estuardo Lopez-Vera, Pradip K. Bandyopadhyay
  • J-SUPERFAMILY CONOTOXIN PEPTIDES
    Publication number: 20110064668
    Abstract: The invention relates to relatively short peptides (termed J-Superfamily conotoxin peptides, J-conotoxins or J-conotoxin peptides herein), about 25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. The J-conotoxins are useful for treating disorders involving voltage gated ion channels and/or receptors.
    Type: Application
    Filed: June 6, 2007
    Publication date: March 17, 2011
    Applicants: UNIVERSITY OF UTAH RESEARCH FOUNDATION, THE UNIVERSITY OF QUEENSLAND, MAX-PLANCK SOCIETY
    Inventors: Julita S. Imperial, Baldomero M. Olivera, Paul F. Alewood, Heinz Terlau, David J. Craik, Estuardo Lopez-Vera, Pradip K. Bandyopadhyay
  • TYROSINE-RICH CONOPEPTIDES
    Publication number: 20100093620
    Abstract: The invention relates to relatively short peptides (termed Conopeptide-Y family peptides or CPY family peptides or CPY peptides herein), about 30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which are rich in the amino acid tyrosine.
    Type: Application
    Filed: April 30, 2009
    Publication date: April 15, 2010
    Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Julita S. IMPERIAL, Baldomero M. OLIVERA, Heinrich TERLAU, Paul F. ALEWOOD, David J. CRAIK
  • Omega-conotoxin peptides
    Patent number: 5591821
    Abstract: The present invention is directed to .omega.-conotoxin peptides having 24-30 amino acids, six cysteines which form disulfide bonds between the first and fourth, second and fifth, and third and sixth cysteines, respectively, and an internal sequence of Cys-Arg-Lys-Thr-Xaa.sub.1 -Tyr-Xaa.sub.2 -Cys-Cys-Ser-Gly-Ser-Cys (SEQ ID NO:1). The invention is further directed to .omega.-conotoxin peptides of the generic formula Cys-Xaa.sub.1 -Gly-Xaa.sub.2 -Gly-Ala-Xaa.sub.3 -Cys-Arg-Lys-Thr-Xaa.sub.4 -Tyr-Xaa.sub.5 -Cys-Cys-Ser-Gly-Ser-Cys-Xaa.sub.6 -Arg-Gly-Xaa.sub.7 -Cys (SEQ ID NO:2). Preferably, the C-terminus is amidated. These peptides also contain three disulfide bonds. Examples of .omega.-conotoxin peptides within the generic formula are MVIIC having the formula Cys-Cys-Gly-Lys-Gly-Ala-Xaa.sub.1 -Cys-Arg-Lys-Thr-Xaa.sub.2 -Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys (SEQ ID NO:3), wherein Xaa is preferably Pro or Hyp (4-hydroxyproline) and Xaa.sub.
    Type: Grant
    Filed: July 16, 1993
    Date of Patent: January 7, 1997
    Assignee: The University of Utah
    Inventors: Baldomero M. Olivera, David R. Hillyard, Julita S. Imperial, Virginia D. Monje