Patents by Inventor Julius Knowles

Julius Knowles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof
    Patent number: 7575757
    Abstract: The present invention provides compositions and stable liquid formulations comprising alpha adrenergic receptor antagonists and use thereof for increasing blood flow. In one embodiment, the stable liquid formulations of this invention are useful for reversing the effects of an anesthetic agent, preferably a long-lasting local anesthetic agent administered in conjunction with an alpha adrenergic receptor agonist.
    Type: Grant
    Filed: March 18, 2005
    Date of Patent: August 18, 2009
    Assignee: Novalar Pharmaceuticals, Inc.
    Inventors: Andrew X. Chen, Julius Knowles, Eckard Weber
  • Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof
    Patent number: 7569230
    Abstract: The present invention provides compositions and stable liquid formulations comprising alpha adrenergic receptor antagonists and use thereof for increasing blood flow. In one embodiment, the stable liquid formulations of this invention are useful for reversing the effects of an anesthetic agent, preferably a long-lasting local anesthetic agent administered in conjunction with an alpha adrenergic receptor agonist.
    Type: Grant
    Filed: December 15, 2006
    Date of Patent: August 4, 2009
    Assignee: Novalar Pharmaceuticals, Inc.
    Inventors: Andrew X Chen, Julius Knowles, Eckard Weber
  • Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof
    Patent number: 7229630
    Abstract: The present invention provides compositions and stable liquid formulations comprising alpha adrenergic receptor antagonists and use thereof for increasing blood flow. In one embodiment, the stable liquid formulations of this invention are useful for reversing the effects of an anesthetic agent, preferably a long-lasting local anesthetic agent administered in conjunction with an alpha adrenergic receptor agonist.
    Type: Grant
    Filed: June 20, 2003
    Date of Patent: June 12, 2007
    Assignee: Novalar Pharmaceuticals, Inc.
    Inventors: Andrew X. Chen, Julius Knowles, Eckard Weber
  • Stabilized Formulations of alpha Adrenergic Receptor Antagonists and the Uses Thereof
    Publication number: 20070098748
    Abstract: The present invention provides compositions and stable liquid formulations comprising alpha adrenergic receptor antagonists and use thereof for increasing blood flow. In one embodiment, the stable liquid formulations of this invention are useful for reversing the effects of an anesthetic agent, preferably a long-lasting local anesthetic agent administered in conjunction with an alpha adrenergic receptor agonist.
    Type: Application
    Filed: December 15, 2006
    Publication date: May 3, 2007
    Inventors: Andrew CHEN, Julius Knowles, Eckard Weber
  • Drug delivery systems for stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof
    Publication number: 20060257388
    Abstract: The present invention provides compositions and stable liquid formulations comprising alpha adrenergic receptor antagonists and use thereof for increasing blood flow. In one embodiment, the stable liquid formulations of this invention are useful for reversing the effects of an anesthetic agent, preferably a long-lasting local anesthetic agent administered in conjunction with an alpha adrenergic receptor agonist. The invention further relates to drug delivery systems for administering alpha adrenergic receptor antagonists.
    Type: Application
    Filed: May 13, 2005
    Publication date: November 16, 2006
    Inventor: Julius Knowles
  • Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof
    Publication number: 20050203099
    Abstract: The present invention provides compositions and stable liquid formulations comprising alpha adrenergic receptor antagonists and use thereof for increasing blood flow. In one embodiment, the stable liquid formulations of this invention are useful for reversing the effects of an anesthetic agent, preferably a long-lasting local anesthetic agent administered in conjunction with an alpha adrenergic receptor agonist.
    Type: Application
    Filed: March 18, 2005
    Publication date: September 15, 2005
    Inventors: Andrew Chen, Julius Knowles, Eckard Weber
  • Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof
    Publication number: 20040044019
    Abstract: The present invention provides compositions and stable liquid formulations comprising alpha adrenergic receptor antagonists and use thereof for increasing blood flow. In one embodiment, the stable liquid formulations of this invention are useful for reversing the effects of an anesthetic agent, preferably a long-lasting local anesthetic agent administered in conjunction with an alpha adrenergic receptor agonist.
    Type: Application
    Filed: June 20, 2003
    Publication date: March 4, 2004
    Inventors: Andrew X. Chen, Julius Knowles, Eckard Weber
  • Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof
    Publication number: 20030236306
    Abstract: Methods of reversing local anesthesia are disclosed. The methods comprise administering a local anesthetic and alpha adrenergic receptor agonist to induce local anesthesia followed by reversing anesthesia with a stable liquid formulation comprising an alpha adrenergic receptor antagonist. Also disclosed are stable liquid formulations comprising an alpha adrenergic receptor antagonist and kits comprising a local anesthetic, an alpha adrenergic receptor agonist and a stable liquid formulation comprising an alpha adrenergic receptor antagonist.
    Type: Application
    Filed: December 2, 2002
    Publication date: December 25, 2003
    Inventors: Andrew X. Chen, Julius Knowles, Eckard Weber, Howard I. Katz