Patents by Inventor Julius N. Korley

Julius N. Korley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic agent delivery system and method
    Patent number: 10045937
    Abstract: A therapeutic agent delivery system includes a therapeutic agent delivery platform and a therapeutic guest agent. The therapeutic agent delivery platform is capable of being implanted in a tissue being treated. The platform includes a substrate and at least one host molecule coupled to the substrate. The therapeutic guest agent is capable of reversibly coupling with the host molecule when administered to the tissue being treated. The reversible coupling is defined by the binding affinity between the host molecule and the therapeutic guest agent. The therapeutic guest agent is delivered at a rate determined by the affinity release rate between the host molecule and the therapeutic guest agent. The degradation rate of the therapeutic guest agent may be slower than the affinity release rate between the host molecule and the therapeutic guest agent.
    Type: Grant
    Filed: June 3, 2010
    Date of Patent: August 14, 2018
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Horst A. von Recum, Julius N. Korley
  • THERAPEUTIC AGENT DELIVERY SYSTEM AND METHOD
    Publication number: 20150010608
    Abstract: A therapeutic agent delivery system includes a therapeutic agent delivery platform and a therapeutic guest agent. The therapeutic agent delivery platform is capable of being implanted in a tissue being treated. The platform includes a substrate and at least one host molecule coupled to the substrate. The therapeutic guest agent is capable of reversibly coupling with the host molecule when administered to the tissue being treated. The reversible coupling is defined by the binding affinity between the host molecule and the therapeutic guest agent. The therapeutic guest agent is delivered at a rate determined by the affinity release rate between the host molecule and the therapeutic guest agent. The degradation rate of the therapeutic guest agent may be slower than the affinity release rate between the host molecule and the therapeutic guest agent.
    Type: Application
    Filed: August 5, 2014
    Publication date: January 8, 2015
    Inventors: Horst A. von Recum, ThimmaReddy Thatiparti, Julius N. Korley, Travis Sill, Iryna Makovey
  • THERAPEUTIC AGENT DELIVERY SYSTEM AND METHOD
    Publication number: 20120220518
    Abstract: A therapeutic agent delivery system includes a therapeutic agent delivery platform and a therapeutic guest agent. The therapeutic agent delivery platform is capable of being implanted in a tissue being treated. The platform includes a substrate and at least one host molecule coupled to the substrate. The therapeutic guest agent is capable of reversibly coupling with the host molecule when administered to the tissue being treated. The reversible coupling is defined by the binding affinity between the host molecule and the therapeutic guest agent. The therapeutic guest agent is delivered at a rate determined by the affinity release rate between the host molecule and the therapeutic guest agent. The degradation rate of the therapeutic guest agent may be slower than the affinity release rate between the host molecule and the therapeutic guest agent.
    Type: Application
    Filed: June 3, 2010
    Publication date: August 30, 2012
    Applicant: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Horst A. von Recum, ThimmaReddy Thatiparti, Julius N. Korley, Travis Sill, Iryna Makovey