Patents by Inventor Julius Rebek, Jr.

Julius Rebek, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OXAZOLE-PYRIDAZINE-OXAZOLE ALPHA-HELIX MIMETIC
    Publication number: 20100113466
    Abstract: There are provided alpha helix scaffolds mimicking i, i+3/i+4, i+7 or i+11 residues having the general structure oxazole-pyridazine-piperidine or oxazole-pyridazine-oxazole. The common pyridazine heterocycle originates from substituted or unsubstituted dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate. These scaffolds are synthetic counterparts of amphiphilic alpha helices having a hydrophilic face along one side and a hydrophobic face along the other side of the helix.
    Type: Application
    Filed: October 8, 2009
    Publication date: May 6, 2010
    Applicants: Office of Patent Counsel
    Inventors: Julius Rebek, JR., Lionel Moisan
  • ALPHA-HELIX MIMETIC WITH FUNCTIONALIZED PYRIDAZINE
    Publication number: 20100022549
    Abstract: The synthesis of new ?-helix scaffolds mimicking i, i+3 or i+4, i+7 residues, was accomplished. The common pyridazine heterocycle originates from the easily available dimethyl pyridazine-3,6-dicarboxylate building block. These scaffolds may be thought of as synthetic counterparts of amphiphilic ?-helices having a hydrophilic face along one side and a hydrophobic face along the other side of the helix.
    Type: Application
    Filed: July 23, 2009
    Publication date: January 28, 2010
    Applicant: The Scripps Research Institute
    Inventors: Julius Rebek, JR., Lionel Moisan, Alexandre Carella, Enrique Mann
  • NOVEL SCAFFOLDS FOR ALPHA-HELIX MIMICRY
    Publication number: 20090298835
    Abstract: Functionalized pyridazine derivatives having a low molecular weight and pharmaceutical compositions thereof are useful as alpha-helix mimetics and for treating conditions and/or disorders mediated by alpha-helix-binding receptors and proteins.
    Type: Application
    Filed: July 15, 2009
    Publication date: December 3, 2009
    Applicant: The Scripps Research Institute
    Inventors: Julius Rebek, JR., Shen Gu, Shannon Biros
  • Scaffolds for ?-helix mimicry
    Patent number: 7579350
    Abstract: Functionalized pyridazine derivatives having a low molecular weight and pharmaceutical compositions thereof are useful as alpha-helix mimetics and for treating conditions and/or disorders mediated by alpha-helix-binding receptors and proteins.
    Type: Grant
    Filed: March 3, 2006
    Date of Patent: August 25, 2009
    Assignee: The Scripps Research Institute
    Inventors: Julius Rebek, Jr., Shen Gu, Shannon Biros
  • OXAZOLE-PYRROLE-PIPERAZINE ALPHA-HELIX MIMETIC
    Publication number: 20090197895
    Abstract: Amphiphilic ?-helix mimetics are provided. These compounds are constructed using an oxazole-pyrrole-piperazine (OPP) scaffold. The amphiphilic ?-helix mimetics are also employable for making libraries and for treating diseases or conditions effected by the inhibition or disruption of interactions with the alpha helix of a protein.
    Type: Application
    Filed: January 30, 2009
    Publication date: August 6, 2009
    Applicant: The Scripps Research Institute
    Inventors: Julius Rebek, JR., Shannon Biros, Lionel Moisan, Severin Odermatt
  • Pyridazine based alpha-helix mimetics
    Publication number: 20090069334
    Abstract: The synthesis of new ?-helix scaffolds mimicking i, i+3 or i+4, i+7 residues, was accomplished. The common pyridazine heterocycle originates from the easily available building block, 6. These scaffolds may be thought of as synthetic counterparts of amphiphilic ?-helices having a “wet face” along one side and a hydrophobic face along the other side of the helix.
    Type: Application
    Filed: August 13, 2008
    Publication date: March 12, 2009
    Applicant: The Scripps Research Institute
    Inventors: Julius Rebek, JR., Shannon Biros, Lionel Moisan, Alessandro Volonterio, Enrique Mann, Trevor Dale
  • Glycoluril core molecules for combinatorial libraries
    Patent number: 7126006
    Abstract: The present invention provides novel glycoluril derivatives for use as core molecules in combinatorial chemistry. Core molecules of the present invention can contain from one to six building blocks. Preferred building blocks are substituted amine radicals. Combinatorial libraries containing such core molecules are also provided.
    Type: Grant
    Filed: May 19, 2005
    Date of Patent: October 24, 2006
    Assignee: The Scripps Research Institute
    Inventors: Julius Rebek, Jr., Kent E. Pryor
  • Glycoluril core molecules for combinatorial libraries
    Patent number: 6939973
    Abstract: The present invention provides novel glycoluril derivatives for use as core molecules in combinatorial chemistry. Core molecules of the present invention can contain from one to six building blocks. Preferred building blocks are substituted amine radicals. Combinatorial libraries containing such core molecules are also provided.
    Type: Grant
    Filed: February 9, 1999
    Date of Patent: September 6, 2005
    Assignee: The Scripps Research Institute
    Inventors: Julius Rebek, Jr., Kent E. Pryor
  • Process for creating molecular diversity and novel protease inhibitors produced thereby
    Patent number: 5877030
    Abstract: Methods for forming combinatorial libraries and the libraries produced thereby are provided. According to a preferred aspect of the invention, a plurality of core molecules are reacted with a plurality of different tool molecules to form a library of molecules having non-naturally occurring molecular diversity. The libraries are useful for identifying lead compounds which modulate the functional activity of a biological molecule. Protease inhibitors that have been isolated from the libraries also are disclosed.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: March 2, 1999
    Inventors: Julius Rebek, Jr., Thomas Carell, Edward A. Wintner