Abstract: Provided is a high-function organoid composition. Also provided is a method of producing the organoid composition. The organoid composition is characterized by including: an organoid including a cell cluster of endodermal cells; and an amphiphilic block polymer having a hydrophilic block chain having a sarcosine unit and a hydrophobic block chain having a lactic acid unit. The organoid composition may be produced by culturing the endodermal cells in a culture system containing the amphiphilic block polymer. The organoid composition thus obtained can evaluate pharmacokinetics and drug toxicity, and is hence suitable for drug screening.

Abstract: Provided is a construction machine capable of accurately notifying a worker that a prime mover is in a drive state. The construction machine includes a prime mover, a heat exchanger, a fan that blows air to the heat exchanger, a controller, and notification units. Only when all of a plurality of notification judgment conditions, which include a condition that the prime mover is in a drive state and a drive sound condition for judging that the drive sound of the fan is low, are satisfied, the controller inputs a notification instruction to the notification units. With input of the notification instruction, the notification units perform notification that the prime mover is in a drive state.

Abstract: A construction machine is provided, in which an electric application instruction detection section detects an electric application instruction of starting an electric application to an electronic device requiring operation confirmation prior to a start of an engine, a timer section measures elapsed time from a start of the electric application to the device, a battery control section executes control of starting the electric application to the device in response to detection of the instruction, an engine control section executes control of starting the engine in a case where a start manipulation is received before the elapsed time exceeds a first reference time set in advance, and a control device executes control of suppressing power consumption of a battery, when at least one power consumption suppression condition set in advance is satisfied after the electric application to the device is started and before the engine is started.

Abstract: Provide is a construction machine allowing an air cleaner to be located entirely low while securing dust-discharge function thereof, with no risk of adverse effects such as diffusion of dusts and complication in structure. The construction machine includes an engine and an air cleaner connected to an intake-side portion of the engine to filter intake air. The air cleaner includes an air-cleaner main body which filters the intake air and an evacuator which discharges dusts separated from the intake air and protrudes downward beyond the air-cleaner main body. The air-cleaner main body is placed on an air-cleaner placement surface, the evacuator protruding downward beyond the air-cleaner placement surface at a position deviated outward from the air-cleaner placement surface.

Abstract: Provided is a construction machine including: an upper slewing body including an upper frame; an engine room on the rear portion of the upper frame; a cabin on the front portion on the right or left side of the upper frame; a plurality of tanks including a fuel tank and a hydraulic tank installed on the upper frame; an air cleaner; a center foothold on the intermediate portion in the width direction of the upper frame and forward of the engine room; and a climbing step at the opposite side to the cabin. A first tank of the plurality of tanks is placed on a portion on the right or left side of the upper frame, and a second tank is arranged on a portion between the cabin and the engine room on the opposite side to the first tank. The air cleaner is superposed on the second tank.

Abstract: Provided is a construction machine including: an upper slewing body including an upper frame; an engine room on the rear portion of the upper frame; a cabin on the front portion on the right or left side of the upper frame; a plurality of tanks including a fuel tank and a hydraulic tank installed on the upper frame; an air cleaner; a center foothold on the intermediate portion in the width direction of the upper frame and forward of the engine room; and a climbing step at the opposite side to the cabin. A first tank of the plurality of tanks is placed on a portion on the right or left side of the upper frame, and a second tank is arranged on a portion between the cabin and the engine room on the opposite side to the first tank. The air cleaner is superposed on the second tank.

Abstract: Provide is a construction machine allowing an air cleaner to be located entirely low while securing dust-discharge function thereof, with no risk of adverse effects such as diffusion of dusts and complication in structure. The construction machine includes an engine and an air cleaner connected to an intake-side portion of the engine to filter intake air. The air cleaner includes an air-cleaner main body which filters the intake air and an evacuator which discharges dusts separated from the intake air and protrudes downward beyond the air-cleaner main body. The air-cleaner main body is placed on an air-cleaner placement surface, the evacuator protruding downward beyond the air-cleaner placement surface at a position deviated outward from the air-cleaner placement surface.

Abstract: A construction machine that permits an exhaust gas after-treatment device to be disposed while avoiding an increase of height and hence avoiding narrowing of an operator's visual field. A guard panel is disposed substantially in parallel with a base frame. The guard panel includes a top plate, the top plate including an opening formed at a portion thereof corresponding to an engine, and a bonnet formed so as to project upwards from the top plate and cover the opening. A first treatment section is disposed lower than the top plate and a second treatment section includes at least a portion positioned higher than the top plate through the opening and lower than the bonnet.

Abstract: A construction machine that permits an exhaust gas after-treatment device to be disposed while suppressing an increase of height. An upper surface of a hydraulic pump is positioned lower than an upper surface of an engine, a tank device having at least one of a working oil tank and a fuel tank is provided at a rear portion thereof with a small height portion which has an upper surface of a height almost equal to or smaller than the height of the upper surface of the hydraulic tank, and an exhaust gas after-treatment device is disposed at a position above both the small height portion and the hydraulic pump.

Abstract: The present invention provides a construction machine, capable of enhancing the cooling efficiency of an air-cooled cooler for EGR without deterioration of the cooling effect of a heat exchanger in spite of the arrangement of the air-cooled cooler for EGR near a cooling fan. The construction machine includes: an EGR line 20 for extracting and recirculating a part of exhaust gas from the exhaust side of an engine 9 to the intake side; and an air-cooled cooler 21 for EGR for cooling the recirculating gas flowing in the EGR line 20. The air-cooled cooler 21 for EGR is provided on the outer circumferential side of a cooling fan 11 in a position between the engine 9 and the cooling fan 11 or a position on the downstream side of the cooling fan 11, and cooled with cooling air flowing on the outer circumferential side of the cooling fan 11.

Abstract: A construction machine that permits an exhaust gas after-treatment device to be disposed while avoiding an increase of height and hence avoiding narrowing of an operator's visual field. A guard panel is disposed substantially in parallel with a base frame. The guard panel includes a top plate, the top plate including an opening formed at a portion thereof corresponding to an engine, and a bonnet formed so as to project upwards from the top plate and cover the opening. A first treatment section is disposed lower than the top plate and a second treatment section includes at least a portion positioned higher than the top plate through the opening and lower than the bonnet.

Abstract: A construction machine that permits an exhaust gas after-treatment device to be disposed while suppressing an increase of height. An upper surface of a hydraulic pump is positioned lower than an upper surface of an engine, a tank device having at least one of a working oil tank and a fuel tank is provided at a rear portion thereof with a small height portion which has an upper surface of a height almost equal to or smaller than the height of the upper surface of the hydraulic tank, and an exhaust gas after-treatment device is disposed at a position above both the small height portion and the hydraulic pump.