Abstract: A combined cabinet and freezer includes a cabinet housing, a refrigeration component, a control panel, a cup holder mechanism, and/or a charging component. An interior of the cabinet housing is hollow, and an interaction area is disposed on an outer surface of the cabinet housing. The refrigeration component includes a door capable of being movably opened. The refrigeration component is embedded in the cabinet housing. The door is exposed out of the cabinet housing. The control panel is disposed in the interaction area. The control panel is electrically connected to the refrigeration component. The control panel is configured to control refrigeration and heating of the refrigeration component. The cup holder mechanism is disposed in the interaction area, and the cup holder mechanism is configured to hold a container. The charging component is disposed in the interaction area, and the charging component is electrically connected to the control panel.

Abstract: A substrate, a manufacturing method thereof, and a sensor module. The substrate includes a base substrate (21) configured to be connected with a chip (10), and the base substrate is provided with a plurality of through-holes (100) penetrating the base substrate (21) in a direction perpendicular to the chip (10). Stacked structures are provided sequentially within the through-holes (100) in a direction perpendicular to and away from the base substrate (21), and thermal expansion coefficients of each layer in the stacked structures are different. The stacked structures include a first conductive portion (241) electrically connected to the chip (10).

Abstract: A method for structural backfilling behind a hydraulic support by combined gabion-stone stacking is provided. Loose gangue produced at the working face is loaded into standardized box-shaped gabion cages to obtain gabion blocks, the gabion blocks are lifted and stacked to form a dry-stacked strip wall via a lifting-stacking device of a backfilling-dedicated hydraulic support, and the dry-stacked strip wall is consolidated into an integral structure by the combined reinforcement approach of “external shotcreting and internal grouting”, thereby forming multiple parallel strip-shaped backfilling bodies behind a working face. A continuous-extraction and continuous-backfilling method with a high degree of mechanization and integration is provided. During advancement of the working face, gangue is not hoisted to the ground surface but is recycled underground.

Abstract: The present invention provides a steroid-cationic lipid compound having a structure represented by formula (I), and use thereof. The compound can be used in the preparation of lipid nanoparticles (LNPs) for delivering a therapeutic agent and/or a prophylactic agent. The LNPs prepared by using the steroid-cationic lipid compound of the present invention have good stability and transfection efficiency. The LNPs are used for delivering nucleic acid, such as mRNA, and can efficiently and stably deliver a bioactive substance to a target cell or organ. In addition, the LNPs have high stability, can be used for developing a freeze-dried preparation of mRNA, can also be used for aerosol inhalation administration of mRNA, and can cause a high specific antibody response in an experimental animal body, and the compound is safer.

Abstract: A broad-spectrum disease resistance-related protein derived from wheat and related biomaterials and use thereof are provided. The protein is selected from the group consisting of A1) a protein with the amino acid sequence of SEQ ID NO: 1; A2) a protein having more than 80% identity to, having a same function as the protein with the amino acid sequence of SEQ ID NO: 1, and obtained by substitutions and/or deletions and/or additions of amino acid residues thereof, and A3) a fusion protein with a same function obtained by joining a tag at N-terminus and/or C-terminus of A1) or A2). The TaCNGC5.1 overexpression lines showed significantly improved disease resistance, thus suggesting that TaCNGC5.1 may play an important role in breeding plants with improved resistance to stripe rust.

Abstract: Performing a three-dimensional (3D) reconstruction process of a set of selected image frames. In some instances, a plurality of sequential image frames that are extracted from a video file (including video content created through the use of Augmented Reality) are converted into a grayscale format. Once these image files are converted to a grayscale format, a two-dimensional (2D) entropy process is performed that is ultimately used to create a set of user-defined clusters, with each of these user-defined clusters being associated with at least a sub-set set of the grayscale frames. After a cluster is selected, a 3D reconstruction process is performed on the frames associated with the selected cluster.

Abstract: The present disclosure provides fusion proteins comprising modified spacer domains that increases the antigen binding affinity, antibodies directing against CD19, and their use in the treatment of disease thereof.

Abstract: Provided are a pharmaceutical composition for treating colorectal cancer and use thereof. Active ingredients of the pharmaceutical composition comprise: polyethylene glycol modified IL-2 and capecitabine. The pharmaceutical composition shows a very good therapeutic effect in an animal model of colorectal cancer. The effect is remarkably superior to that of a single drug, and thus the pharmaceutical composition has a good application prospect.

Abstract: The present application discloses a virtual column construction method based on data lake and a data query method. The present disclosure includes: first, automatically performing expression statistical analysis on a large quantity of statements to be analyzed in a data lake, so as to obtain an expression to be used; next, automatically constructing a virtual column construction request corresponding to the expression to be used, according to virtual column construction description information corresponding to the expression to be used, so that the virtual column construction request is used to request construction of a virtual column that can represent the expression to be used; then, according to the virtual column construction request, constructing a virtual column corresponding to the expression to be used, to enable the virtual column to represent the expression to be used.

Abstract: A pipe clamp, a piping system including the pipe clamp, and an air conditioner. The piping clamp is used for the piping system of the air conditioner. The pipe clamp includes a pipe clamp body having a plurality of clamping grooves arranged side by side. The clamping groove extends through two opposite sides of the pipe clamp body to be adapted to a pipe. The clamping groove has an opening at a side of the clamping groove. The opening has a width smaller than an outer diameter of the pipe. The opening has an adjustable opening size. The opening is adapted to allow the pipe to be clamped into the clamping groove via the opening.

Abstract: A steroid-cationic lipid compound as represented by formula (I). The LNP prepared from the compound can deliver a bioactive substance to a target cell or organ in an effective and stable manner, and the mRNA LNP prepared from the compound has good levels of stability and transfection efficiency, and can trigger a relatively high specific antibody response and cellular immune response in an animal.

Abstract: A data management system may receive datasets from one or more data sources. The data management system may store the datasets belonging to a domain. The data management system may check data integrity of the datasets. The data management system may perform a quality control check on the datasets. The data management system may receive selections from the domain on the datasets that are selected to be processed based on one or more reference libraries. The data management system may process one or more selected datasets based on the reference libraries. The data management system may integrate the data with metadata to provide an integrated analysis. A data management platform of the organization domain allows the datasets and the integrated analysis to be analyzed.

Abstract: Provided is an interfering RNA targeting Janus kinase 1 (JAK1). The interfering RNA can reduce the expression of JAK1 and further inhibit the activation of a JAK/STAT signaling pathway, thereby achieving the purpose of treating a JAK/STAT signaling pathway dysregulation-associated disease. Further provided is a lipid nanoparticle drug containing the interfering RNA for use in treating a JAK/STAT signaling pathway dysregulation-associated disease. Further provided is an antibody-nucleic acid drug conjugate containing the interfering RNA for use in treating a JAK/STAT signaling pathway dysregulation-associated disease.

Abstract: Generating transportation network solutions using graph neural networks, includes: generating, based on input data describing a product transportation network, a graph neural network representing the product transportation network, wherein the graph neural network comprises multiple edges, multiple source nodes, multiple destination nodes, and multiple intermediary nodes; performing a graph neural network prediction based on the graph neural network, wherein performing the graph neural network prediction comprises predicting inclusion in the transportation network solution for each edge and intermediary node; and generating a transportation network solution by performing a model optimization using an initial state based on the graph neural network prediction.

Abstract: The present invention provides an interfering RNA targeting TOP1 gene. The interfering RNA can reduce the expression of TOP1, thereby treating a disease related to TOP1 expression. The present invention further provides a lipid nanoparticle drug comprising the interfering RNA for treating a disease related to TOP1 expression. The present invention further provides an antibody-nucleic acid conjugate drug comprising the interfering RNA for treating a disease related to TOP1 expression.

Abstract: A Monte Carlo tree structure of related software packages for a software project is constructed, wherein one or more vulnerable nodes of the Monte Carlo tree structure indicate a software vulnerability. A Monte Carlo tree search algorithm is applied on the Monte Carlo tree structure, the applying comprising expanding the Monte Carlo tree structure with multiple respective candidate nodes corresponding to alternative software packages for replacement of the one or more vulnerable nodes and performing iterative simulation and backpropagation through different tree updates using the multiple respective candidate nodes to identify at least one best replacement node from the multiple candidate nodes. A repaired software set for the software project is exported, the repaired software set including additional software corresponding to the at least one identified best replacement node, the additional software replacing one or more software packages that are related to the one or more vulnerable nodes.

Abstract: A method for improving wheat resistance to Fusarium head blight (FHB) by genome editing is provided, and further provided is use of TaCIPK14 protein or related biomaterial thereto in the regulation of plant resistance to FHB; the TaCIPK14 protein is TaCIPK14-4A protein (SEQ ID NO: 4), TaCIPK14-4B protein (SEQ ID NO: 5), and/or TaCIPK14-4D protein (SEQ ID NO: 6). TaCIPK14 knockout mutant plants are successfully obtained by simultaneously editing three alleles of TaCIPK14 in wheat using CRISPR-Cas9 gene editing technology. The TaCIPK14 knockout mutant shows resistance to inoculation with FHB pathogens, and the results of evaluation of major agronomic traits confirm that the TaCIPK14 knockout mutant reserves the major agronomic traits.

Abstract: Disclosed is a method for remining a residual coal pillar in a residual mining area by collaboration of pillar-side backfilling and in-situ gasification. The method includes the following steps of: ascertaining geological and hydrological conditions, a geometric shape and a reserve of a residual coal pillar; carrying out side supporting on the residual coal pillar in a goaf by using a pillar-side backfilling method; and carrying out the underground gasification mining on the residual coal pillar by means of an underground coal gasification process.