Abstract: The present invention has revealed that an antiviral agent containing a serine protease such as subtilisin, nattokinase, and trypsin has an effect of inactivating non-envelope type viruses, and that combining such an antiviral agent containing a serine protease with a cationic polymer enhances the inactivation effect of the antiviral agent against non-envelope type viruses. As a result, an antiviral agent that is highly safe, that has a high virus inactivation ability, and that contains a component that is inexpensive in terms the manufacturing cost and a cationic polymer, was discovered.

Abstract: The present invention provides a compound selected from sulfated cellulose and salts thereof which can be used as an active ingredient for a cutaneous external preparation produced intending to prevent, soften, improve or cure atopic cutaneous symptoms and the like and which are excellent in a hydrolytic resistance, and dermatitis therapeutic agents and cosmetics using the same.

Abstract: The present invention provides ?-polylysine represented by formula (1), having a polyorganosiloxane group introduced into the molecule, and a process for production of the ?-polylysine, in which the formula (1) is defined in the specification. The invention further provides an antimicrobial agent comprising an amino group-containing antimicrobial polymer having a polyorganosiloxane group introduced into the molecule, and an antimicrobial resin composition comprising an antimicrobial agent above and a resin.

Abstract: The invention relates to a composition for treating or preventing an oral cavity by preventing adhesion of Porphyromonas gingivalis as periodontopathic bacterium to oral tissue. The invention also relates to a composition for treating or preventing an oral cavity containing a peptide in which arginine and histidine bind alternately. Preferably, the invention includes a composition for treating or preventing an oral cavity including the peptide of a pentamer of (arginine-histidine).

Abstract: PROBLEMS TO BE SOLVED: To provide a highly safe lapactic agent that exhibits a sufficient lapactic effect such as the promotion of catharsis even by the intake of a small quantity, and a food product containing such a lapactic agent having a lapactic effect. MEANS TO SOLVE THE PROBLEMS: A lapactic agent comprising (A) a basic polymer and/or the salt thereof, and (B) a dietary fiber, wherein (A) a basic polymer and/or the salt thereof is at least one selected from the group consisting of polyvinylamine, polyallylamine, polyethyleneimine, polyvinylpyridine, poly (N,N-dimethylaminoethyl acrylate), ?-polylysine, a copolymer formed from a monomer having an amino group selected from the group consisting of vinylamine, allylamine, vinylpyridine, vinylmethylimidazole, N,N-dimethylaminoethyl acrylate, and N,N-dimethylaminopropyl acrylate; and a salt of these polymers; and a food product containing such a lapactic agent.

Abstract: The invention relates a composition for oral cavity for preventing adhesion of Porphyromonas gingivalis as periodontopathic bacterium to oral tissue. The invention also relates to a composition for oral cavity containing a peptide in which arginine and histidine bind alternately. Preferably, the invention includes a composition for oral cavity including the peptide of a pentamer of (arginine-histidine).

Abstract: The present invention provides a compound selected from sulfated cellulose and salts thereof which can be used as an active ingredient for a cutaneous external preparation produced intending to prevent, soften, improve or cure atopic cutaneous symptoms and the like and which are excellent in a hydrolytic resistance, and dermatitis therapeutic agents and cosmetics using the same.

Abstract: It has been desired to develop a highly preservative and antibacterial cosmetic composition that can easily be applied to both emulsion and non-emulsion type cosmetics. It has also been desired to develop a method of improving a preservative and/or antibacterial effect(s) of a cosmetic composition comprising polyorganosiloxane-containing epsilon-polylysine and thereby reducing the amount of antibacterial preservative agent to be used. There is provided a cosmetic composition comprising one or a combination of two or more of polyorganosiloxane-containing epsilon-polylysine compounds obtained by reacting epsilon-polylysine with polyorganosiloxane or a physiologically acceptable salt thereof, and polyhydric alcohol.

Abstract: The present invention provides &egr;-polylysine represented by formula (1), having a polyorganosiloxane group introduced into the molecule, and a process for production of the &egr;-polylysine, in which the formula (1) is defined in the specification. The invention further provides an antimicrobial agent comprising an amino group-containing antimicrobial polymer having a polyorganosiloxane group introduced into the molecule, and an antimicrobial resin composition comprising an antimicrobial agent above and a resin.

Abstract: PROBLEMS TO BE SOLVED: To provide a highly safe lapactic agent that exhibits a sufficient lapactic effect such as the promotion of catharsis even by the intake of a small quantity, and a food product containing such a lapactic agent having a lapactic effect. MEANS TO SOLVE THE PROBLEMS: A lapactic agent comprising (A) a basic polymer and/or the salt thereof, and (B) a dietary fiber, wherein (A) a basic polymer and/or the salt thereof is at least one selected from the group consisting of polyvinylamine, polyallylamine, polyethyleneimine, polyvinylpyridine, poly (N,N-dimethylaminoethyl acrylate), &egr;-polylysine, a copolymer formed from a monomer having an amino group selected from the group consisting of vinylamine, allylamine, vinylpyridine, vinylmethylimidazole, N,N-dimethylaminoethyl acrylate, and N,N-dimethylaminopropyl acrylate; and a salt of these polymers; and a food product containing such a lapactic agent.

Abstract: The incorporation of &egr;-polylysine or salt thereof (&egr;PL) having a water content of not more than 15% by weight in a resin composition makes it possible to obtain an antibacterial resin composition excellent in antibacterial capacity and safe in use. Since the &egr;PL can be fairly dispersed in the resin, the resulting molded article is not liable to destruction of external appearance. Accordingly, the antibacterial resin composition of the present invention can find good and wide application in medical sanitary goods, tableware, daily necessaries, automobile interior material, household appliance, film, sheet, fiber, coating compound such as paint, ink, and other goods which must be antibacterial. Further, the molded articles obtained from the resin composition according to the present invention can maintain its antibacterial effect even after repeated use and thus can be used over an extended period of time.

Abstract: An effective process for producing .epsilon.-poly-L-lysine is provided, which process comprises cultivating a microorganism having .epsilon.-poly-L-lysine productivity, such as a bacterium belonging to the Streptomyces genus, in the form of immobilized bacterial cells under aerobic conditions, and according to which process, the bacterial cells cause no bacteriolysis; the immobilized bacterial cells retaining .epsilon.-poly-L-lysine productivity can be easily separated and recovered from the culture solution containing .epsilon.-poly-L-lysine; and semi-continuous or continuous production of .epsilon.-poly-L-lysine by the use of the immobilized bacterial cells is possible.

Abstract: An antibacterial article inhibits the proliferation of microorganisms on the surface of food. The antibacterial article includes a substrate, such as a nonwoven material, on which is adsorbed .epsilon.-polylysine. The article is produced by applying an aqueous or alcoholic solution of .epsilon.-polylysine to the substrate by spraying or immersion.

Abstract: An enzyme reaction stabilizer consisting of poly-L-lysine or its salt as an effective constituent, a method for using the enzyme reaction stabilizer, and an enzyme preservative consisting of poly-L-lysine or its salt as an effective constituent are disclosed in this invention. While enzyme reactions are carried out, the enzyme reaction stabilizer and the method for using it prevents both the deactivation of enzymes due to the proliferation of included microorganisms and the decomposition of the reaction products and there is an advantage in that the enzyme reaction stabilizer can easily be separated from the reaction products. On the other hand, while the enzyme solution is preserved, the enzyme preservative of this invention prevents the deactivation of the enzyme due to the proliferation of included microorganisms in the enzyme solution or the enzyme preserving solution.

Abstract: The present invention provides variant strains mass-producing .epsilon.PL which are obtained by variant treatment of a strain producing .epsilon.PL. For using the variant strains, the strains are cultured in a cultivated medium, .epsilon.PL is mass-produced and stored in the culture solution, and the stored .epsilon.PL is collected from the solution. For producing .epsilon.PL, a strain which produces .epsilon.PL is variant-treated, the obtained variant strain is cultivated in a culture medium to which L-lysine or L-lysine and one or more sugars are added, .epsilon.PL is mass-produced and stored in the culture solution, and the stored .epsilon.PL is collected from the solution.The variant strains producing .epsilon.PL in large quantities are preferably the strains which have tolerance to an analogue of L-lysine of Streptomyces albulus subsp. lysinopolymerus No. 346-D strain and plasmid-amplifiable variant strains of the same bacteria.

Abstract: The present invention provides mutants mass-producing .epsilon.PL which are obtained by mutation treatment of a strain producing .epsilon.PL. For using the mutants, the mutants are cultured in a cultivated medium, .epsilon.PL is mass-produced and stored in the culture solution, and the stored .epsilon.PL is collected from the solution. For producing .epsilon.PL, a strain which produces .epsilon.PL is mutation-treated, the obtained mutant is cultivated in a culture medium to which L-lysine or L-lysine and one or more sugars are added, .epsilon.PL is mass-produced and stored in the culture solution, and the stored .epsilon.PL is collected from the solution.The mutants producing .epsilon.PL in large quantities are preferably the mutants which have tolerance to an analogue of L-lysine of Streptomyces albulus subsp. lysinopolymerus No. 346-D strain and chloramphenicol-treated mutant of the same bacteria.

Abstract: A whey protein gel which is transparent, thermostable, usable as food and is highly safe without damaging the nutritive value of whey protein, and a process for producing the gel are provided,which gel comprises whey protein dissolved or dispersed in water or a buffer solution and poly-L-lysine or its salt, andwhich process comprises adding poly-L-lysine or its salt to a solution or dispersion of whey protein in water or a buffer solution to effect gelation.

Abstract: The invention provides cosmetics using a freeze-dried material which is obtained by freeze-drying an aqueous solution. The solution contains hyaluronic acid or sodium hyaluronate and magnesium-L-ascrbil phosphate.

Abstract: Ethanol preparations exhibiting a superior effect upon food preservation and also a superior antiseptic effect upon yeasts are provided, which preparations comprise a polylysine or a polylysine salt added to anhydrous ethanol or a water-containing ethanol in an ethanol concentration of 30% by weight or higher.

Abstract: Agent for preventing plant virus diseases such as tobacco mosaic viruses, potato viruses, cucumber mosaic viruses, etc. of this invention is obtained from a new agent containing polylysine as an active component. Polylysine can be used .alpha.-polylysine or .beta.-polylysine.