Abstract: A method for generating a cell line for producing virus in suspension cell culture. The method comprises generating a plurality of cell clones growing in adherent cell culture, identifying a group of cell clones with high transfection efficiency, generating a plurality of cell clones growing in suspension cell culture and identifying a cell clone suitable for producing virus in suspension cell culture. The method disclosed herein the method can shorten the domestication time from at least 1 month to 7-14 days, and the amount of medium used during the domestication process can also be greatly reduced, reducing production costs.

Abstract: The present disclosure provides a scalable and cost-effective method of purifying recombinant viruses, such as recombinant lentiviruses. Also provided herein are recombinant viruses (e.g., lentiviruses) purified using the methods provided herein, which have a low level of impurities and high activity retention.

Abstract: Data characterizing an individual is received. Thereafter, one or more variables are extracted from the data so that, using a predictive model populated with the extracted variables, a likelihood of the individual adhering to a treatment regimen can be determined. The predictive model is trained on historical treatment regimen adherence data empirically derived from a plurality of subjects. Subsequently, data characterizing the determined likelihood of adherence can be promoted.

Abstract: Data characterizing an individual is received. Thereafter, one or more variables are extracted from the data so that, using a predictive model populated with the extracted variables, a likelihood of the individual adhering to a treatment regimen can be determined. The predictive model is trained on historical treatment regimen adherence data empirically derived from a plurality of subjects. Subsequently, data characterizing the determined likelihood of adherence can be promoted.

Abstract: The invention relates to methods for producing rebaudioside D and/or rebaudioside M, and compositions comprising the same. The invention provides a method for producing RD and/or RM compositions. The method comprises using rebaudioside A and/or stevioside as substrate and a recombinant microorganism or an enzyme produced by the recombinant microorganism or a metabolite of the recombinant microorganism to catalyze the reaction of the substrate in the presence of sucrose and trisodium citrate and produce a mixture of rebaudioside D and rebaudioside M, and then separates and purifies the mixture to obtain rebaudioside D or rebaudioside M.

Abstract: Data characterizing an individual is received. Thereafter, one or more variables are extracted from the data so that, using a predictive model populated with the extracted variables, a likelihood of the individual adhering to a treatment regimen can be determined. The predictive model is trained on historical treatment regimen adherence data empirically derived from a plurality of subjects. Subsequently, data characterizing the determined likelihood of adherence can be promoted.

Abstract: The present invention is directed to a use of a lubricant in a diesel engine to disperse soot produced by the diesel engine, the soot being dispersed without adversely affecting the viscosity of the lubricant; the lubricant comprising a major amount of oil of lubricating viscosity and a minor amount of a dispersant comprising (i) one or more olefin, (ii) one or more carboxylic acid, (iii) one or more polyetheramines and (iv) one or more aromatic amines along with co-additives.

Abstract: Data characterizing an individual is received. Thereafter, one or more variables are extracted from the data so that, using a predictive model populated with the extracted variables, a likelihood of the individual adhering to a treatment regimen can be determined. The predictive model is trained on historical treatment regimen adherence data empirically derived from a plurality of subjects. Subsequently, data characterizing the determined likelihood of adherence can be promoted. Related apparatus, systems, techniques and articles are also described.

Abstract: Certain aspects of the present disclosure provide methods and apparatus for generating an envelope tracking power supply voltage. For example, certain aspects of the present disclosure provide an envelope tracking power supply having a linear amplifier having an output coupled to a power supply node of an amplifier, wherein a power supply node of the linear amplifier is coupled to a first voltage supply node. The envelope tracking power supply may also include a switch mode power supply having an output coupled to the power supply node of the amplifier. Certain aspects also include a circuit having a first switch coupled to the first voltage supply node and a second switch coupled to a second voltage supply node, wherein a power supply node of the switch mode power supply is coupled to the first switch and the second switch.

Abstract: The invention relates to methods for producing rebaudioside D and/or rebaudioside M, and compositions comprising the same. The invention provides a method for producing RD and/or RM compositions. The method comprises using rebaudioside A and/or stevioside as substrate and a recombinant microorganism or an enzyme produced by the recombinant microorganism or a metabolite of the recombinant microorganism to catalyze the reaction of the substrate in the presence of sucrose and trisodium citrate and produce a mixture of rebaudioside D and rebaudioside M, and then separates and purifies the mixture to obtain rebaudioside D or rebaudioside M.

Abstract: An embodiment in accordance with the present invention provides a new acquisition scheme for T2-weighted BOLD fMRI. It employs a T2 preparation module to induce the BOLD contrast, followed by a single-shot 3D fast gradient echo (GRE) readout with short echo time (TE<2 ms). The separation of BOLD contrast generation from the readout substantially reduces the “dead time” due to long TE required in spin echo (SE) BOLD sequences. This approach termed “3D T2prep-GRE,” can be implemented with any magnetic resonance imaging machine, known to or conceivable by one of skill in the art. This approach is expected to be useful for ultra-high field fMRI studies that require whole brain coverage, or focus on regions near air cavities. The concept of using T2 preparation to generate BOLD contrast can be combined with many other fast imaging sequences at any field strength.

Abstract: A process for producing a borated polyalkenyl succinimide dispersant composition in which the boron is incorporated primarily as cyclic metaboric acid moieties and the equivalents of boron incorporated per equivalent of nitrogen in the succinimide carrier is greater than 2; in which process a slurry of orthoboric acid is added to a polyalkenyl succinimide to form a reaction mixture, which reaction mixture is then heated under conditions (at a temperature and pressure and for a time) sufficient to remove from the reaction mixture from about 0.8 to about 1.2 moles of water of reaction per mole of boric acid charged.

Abstract: Certain aspects of the present disclosure provide methods and apparatus for generating an envelope tracking power supply voltage. For example, certain aspects of the present disclosure provide an envelope tracking power supply having a linear amplifier having an output coupled to a power supply node of an amplifier, wherein a power supply node of the linear amplifier is coupled to a first voltage supply node. The envelope tracking power supply may also include a switch mode power supply having an output coupled to the power supply node of the amplifier. Certain aspects also include a circuit having a first switch coupled to the first voltage supply node and a second switch coupled to a second voltage supply node, wherein a power supply node of the switch mode power supply is coupled to the first switch and the second switch.

Abstract: The present invention is directed to a use of a lubricant in a diesel engine to disperse soot produced by the diesel engine, the soot being dispersed without adversely affecting the viscosity of the lubricant; the lubricant comprising a major amount of oil of lubricating viscosity and a minor amount of a dispersant comprising (i) one or more olefin, (ii) one or more carboxylic acid, (iii) one or more polyetheramines and (iv) one or more aromatic amines along with co-additives.

Abstract: Certain aspects of the present disclosure provide methods and apparatus for generating an envelope tracking power supply voltage. For example, certain aspects of the present disclosure provide an envelope tracking power supply having a linear amplifier having an output coupled to a power supply node of an amplifier, wherein a power supply node of the linear amplifier is coupled to a first voltage supply node. The envelope tracking power supply may also include a switch mode power supply having an output coupled to the power supply node of the amplifier. Certain aspects also include a circuit having a first switch coupled to the first voltage supply node and a second switch coupled to a second voltage supply node, wherein a power supply node of the switch mode power supply is coupled to the first switch and the second switch.

Abstract: Certain aspects of the present disclosure provide methods and apparatus for generating an envelope tracking power supply voltage. For example, certain aspects of the present disclosure provide an envelope tracking power supply having a linear amplifier having an output coupled to a power supply node of an amplifier, wherein a power supply node of the linear amplifier is coupled to a first voltage supply node. The envelope tracking power supply may also include a switch mode power supply having an output coupled to the power supply node of the amplifier. Certain aspects also include a circuit having a first switch coupled to the first voltage supply node and a second switch coupled to a second voltage supply node, wherein a power supply node of the switch mode power supply is coupled to the first switch and the second switch.

Abstract: A process for producing a borated polyalkenyl succinimide dispersant composition in which the boron is incorporated primarily as cyclic metaboric acid moieties and the equivalents of boron incorporated per equivalent of nitrogen in the succinimide carrier is greater than 2; in which process a slurry of orthoboric acid is added to a polyalkenyl succinimide to form a reaction mixture, which reaction mixture is then heated under conditions (at a temperature and pressure and for a time) sufficient to remove from the reaction mixture from about 0.8 to about 1.2 moles of water of reaction per mole of boric acid charged.

Abstract: Disclosed is circuitry having an input stage and an output stage. A first compensation network may be connected to the input and output stages, and configured to split a pole at the input stage and a pole at the output stage. A second compensation network may be connected to the input and output stage. The second compensation network may be configured to suppress peaking of a gain of the circuit at frequencies near the pole at the output stage.

Abstract: Embodiments of the present invention provide a flat panel electronic device and a current control system thereof. The current control system comprises: a detecting module for detecting a current in a main circuit of the flat panel electronic device; and a control mechanism for reducing a brightness level of a backlight unit of the flat panel electronic device when the current in the main circuit is larger than or equal to a threshold so that the current in the main circuit is reduced to be less than the threshold. The current control system provided by the present invention reduces the current in the main circuit by reducing the brightness level of the backlight unit. Therefore, it is able to reduce the processing time by more than 10 ms compared with the prior art, and the fast and effective response is an important factor for extending the life of the battery.

Abstract: An embodiment in accordance with the present invention provides a new acquisition scheme for T2-weighted BOLD fMRI. It employs a T2 preparation module to induce the BOLD contrast, followed by a single-shot 3D fast gradient echo (GRE) readout with short echo time (TE<2 ms). The separation of BOLD contrast generation from the readout substantially reduces the “dead time” due to long TE required in spin echo (SE) BOLD sequences. This approach termed “3D T2prep-GRE,” can be implemented with any magnetic resonance imaging machine, known to or conceivable by one of skill in the art. This approach is expected to be useful for ultra-high field fMRI studies that require whole brain coverage, or focus on regions near air cavities. The concept of using T2 preparation to generate BOLD contrast can be combined with many other fast imaging sequences at any field strength.