Abstract: This invention relates to novel benzothizine derivatives of the formula [I], processes for preparing them and therapeutic agents for circulatory diseases containing them as an active ingredient, ##STR1## wherein R.sup.1 is one or more groups selected from those consisting of hydrogen, lower alkyl, halogen, nitro, hydroxy, lower alkoxy, lower alkanoyloxy, amino, lower alkylamino and lower alkoxycarbonyloxy;R.sup.2 is hydrogen, lower alkyl or (C.sub.3 -C.sub.6)cycloalkyl;R.sup.3 is one or more groups selected from those consisting of hydrogen, lower alkyl, hydroxy, lower alkoxy, halogen, nitro, lower alkylenedioxy, lower alkanoyloxy, lower alkanoyl, amino, lower alkylamino, lower alkanoylamino and lower alkoxycarbonyloxy or ##STR2## R.sup.4 is hydrogen or lower alkyl.

Abstract: This invention relates to benzothiazine derivatives represented by the formula [I] and salts thereof, which are useful for treatment of cardiovascular diseases.

Abstract: The invention relates to benzothiazoline derivatives of the formula [I] and salts thereof, which are useful for (i) treating cardiovascular diseases, and (ii) as the active ingredient of pharmaceutical compositions. Formula [I] follows: ##STR1## wherein R.sup.1 is lower alkanoyl;R.sup.2 is one or more group(s) selected from hydrogen, lower alkyl, lower alkoxy, hydroxy, halogen, nitro, halogenolower alkyl and sulfamoyl;R.sup.3 is --COR.sup.8 ;R.sup.8 is hydroxy, lower alkoxy, ##STR2## Z is straight or branched alkylene containing 1 to 6 carbon atoms; m is 0 or 1; n is 0 or 1; and p is 4 or 5.

Abstract: The invention relates to benzothiazoline derivatives of the formula [I] and salts thereof, which are useful for (i) treating cardiovascular diseases, and (ii) as the active ingredient of pharmaceutical compositions. Formula [I] follows: ##STR1## wherein R.sup.1 is lower alkanoyl;R.sup.2 is one or more group(s) selected from hydrogen, lower alkyl, lower alkoxy, hydroxy, halogen, nitro, halogenolower alkyl and sulfamoyl;R.sup.3 is ##STR2## R.sup.4 and R.sup.5 each is hydrogen, lower alkyl, cyclohexyl or substituted lower alkyl;Z is straight or branched alkylene containing 1 to 6 carbon atoms;m is 0 or 1; n is 0 or 1; and p is 4 or 5.

Abstract: Aletheine derivatives of the general formula ##STR1## which are useful for treatment of liver damage.

Abstract: This invention relates to novel benzothiazoline derivatives of the formula [I] and salts thereof, ##STR1## wherein R.sup.1 is formyl or lower alkanoyl;R.sup.2 is hydrogen, lower alkyl, lower alkoxy or nitro;R.sup.3 is hydrogen, lower alkyl, lower alkoxy or halogen;A is lower alkylene;B is --CO--(CH.sub.2).sub.m -- or --CH(OH)--;m is 0 or 1; andwhen m is 0, R.sup.3 is not hydrogen.The compounds of this invention are useful for treatment of cardiovascular diseases.

Abstract: Novel S-substituted mercapto-lower alkanoyl-4-thiazolidinecarboxylic acids, -2-pyrrolidinecarboxylic acids and their esters represented by the general formula ##STR1## wherein Q is methylene or sulfur;Z is straight or branched alkylene with 1 to 3 carbon atoms, their process for manufacturing, the antihypertensive composition comprising these compounds and the method for reducing blood pressure.

Abstract: Novel S-substituted mercapto-lower alkanoyl-4-thiazolidinecarboxylic acids, -2-pyrrolidinecarboxylic acids and their esters represented by the general formula ##STR1## wherein Q is methylene or sulfur;Z is straight or branched alkylene with 1 to 3 carbon atoms,their process for manufacturing, the antihypertensive composition comprising these compounds and the method for reducing blood pressure.

Abstract: This invention relates to inclusion compounds of cyclodextrin with the compounds of the general formula [I] and salts thereof, which show pharmacological effects (for example antihypertensive effect), ##STR1## wherein A is straight or branched lower alkylene;R.sup.1 is hydrogen or lower alkyl;R.sup.2 is hydrogen, lower alkyl, phenyl, phenyl-lower alkyl, hydroxyphenyl-lower alkyl, hydroxy-lower alkyl, amino-lower alkyl, guanidino-lower alkyl, imidazolyl-lower alkyl, indolyl-lower alkyl, mercapto-lower alkyl or lower alkylthio-lower alkyl;R.sup.1 or R.sup.2 may join to complete pyrrolidine ring or thiazolidine ring, and each ring may be substituted by phenyl or pyridyl, and phenyl may be resubstituted by hydroxy, lower alkoxy, halogen, nitro or sulfamoyl;R.sup.3 is hydrogen or ##STR2## said lower alkyl and lower alkoxy having 1 to 6 carbon atoms.

Abstract: This invention relates to benzothiazoline derivatives of the formula [I] and salts thereof, which are useful for (i) treating cardiovascular diseases, and (ii) as the active ingredient of pharmaceutical compositions. Formula [I] follows: ##STR1## wherein R.sup.1 is lower alkanoyl;R.sup.2 is one or more group(s) selected from hydrogen, lower alkyl, lower alkoxy, hydroxy, halogen, nitro, halogeno-lower alkyl and sulfamoyl;R.sup.3 is ##STR2## R.sup.6 is hydrogen, alkyl, substituted alkyl, alkanoyl, substituted alkanoyl, alkenoyl, substituted alkenoyl or furylcarbonyl;R.sup.7 is hydrogen, hydroxy, phenyl-lower alkyl or banzoyl;Z is strainght or branched alkylene containing 1 to 6 carbon atoms;m is 0 or 1; n is 0 or 1; and p is 5.

Abstract: This invention relates to the compound of the general formula [I], process for preparing the compound and antihypertensive agent containing the compound as a main ingredient. ##STR1## wherein R.sup.1 is hydrogen, hydroxy, lower alkyl or lower alkoxy;R.sup.2 is hydrogen, benzoyl or ##STR2## R.sup.3 is hydroxy, lower alkoxy, --NHOH or ##STR3## R.sup.4 is ##STR4## R.sup.5 is hydrogen or halogen; R.sup.6 and R.sup.7 each is hydrogen or lower alkyl;Z is straight or branched alkylene containing 1 to 3 carbon atoms;when R.sup.3 is hydroxy or lower alkoxy, R.sup.2 is ##STR5## and salts thereof, said lower alkyl and lower alkoxy groups contain 1 to 6 carbon atoms.

Abstract: This invention relates to the new thiazolidine and pyrrolidine compounds represented by the following general formula ##STR1## wherein p1 Q.sup.1 and Q.sup.2 are methylene or sulfur atom; Z is alkylene containing 1 to 3 carbon atoms;R.sup.1 is hydrogen, alkyl, aryl or heterocycle;R.sup.2 is hydrogen, alkyl, acyl, aryl, heterocycle or mercapto radical;R.sup.3 is hydrogen or alkyl;R.sup.4 is hydrogen, alkyl, aryl, pyrroridine ring formed with R.sup.3, or thiazolidine ring formed with R.sup.3 ;R.sup.5 is hydroxy or amino, which may be substituted by alkyl or aryl.The compounds of this invention are synthesized by the condensation of sulfur-containing acyl thiazolidine carboxylic acid or sulfur-containing acyl pyrrolidine carboxylic acid with amino acid.The compounds of this invention are useful for antihypertensive agent.

Abstract: Disulfide compounds which have the general formula ##STR1## and salts thereof used for reducing blood pressure and for preventing or relieving diabetic complications, processes for manufacturing thereof, compositions comprising them and pharmaceutically acceptable excipients, and administering methods are mentioned.

Abstract: Disulfide compounds which have the general formula ##STR1## and salts thereof used for reducing blood pressure and for preventing or relieving diabetic complications, processes for manufacturing thereof, compositions comprising them and pharmaceutically acceptable excipients, and administering methods are mentioned.

Abstract: Derivatives of 5-substituted 2-pyrrolidinecarboxylic acid which have the general formula ##STR1## are useful in compositions as antihypertensive agents.

Abstract: S-Substituted derivatives of N-(2-mercapto-2-methylpropanoyl)-cysteine which have the formula ##STR1## are useful as a medicine for suppressing liver disorders.

Abstract: A method for treating rheumatism and/or arthritis in mammals afflicted therewith by administering an effective amount of N-(2-mercapto-2-methylpropanoyl)-L-cysteine or a pharmacologically acceptable salt thereof.

Abstract: Process for manufacturing optically active sulfur-containing carboxylic acid which comprises reacting a racemic acid of the formula ##STR1## with an optically active amine to form the amine salt, and then resolving the isomers and recovering the optically active isomer.