Patents by Inventor Jun-ichi Oshida

Jun-ichi Oshida has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4H-3,1-benzoxazin-4-one compounds and pharmaceutical compositions thereof for the inhibition of serine proteases
    Patent number: 4980287
    Abstract: A 4H-3,1-benzoxazin-4-one compound of the formula (I): ##STR1## wherein R is a hydrogen atom or alkyl radical, A is an amino acid residue or a peptide having 2 to 3 amino acid residues, which amino acid residue may have a side chain thereof protected by a protective radical, X is an alkyl, fluoroalkyl, OR.sup.1 or NHR.sup.1 radical wherein R.sup.1 is an alkyl radical, and Y is a protective radical for an amino radical, and salts thereof, exhibit an excellent inhibitory activity against serine proteases, especially against human leukocyte elastase, and thus are useful as an effective component of a medicine for inhibiting elastase.
    Type: Grant
    Filed: February 3, 1989
    Date of Patent: December 25, 1990
    Assignee: Teijin Limited
    Inventors: Masayuki Kokubo, Katsuhiko Fujii, Jun-ichi Oshida, Koji Tomimori, Yasuhide Uejima
  • Vitamin D.sub.3 derivatives, process for preparation thereof, and antigens comprising said derivatives to be used for preparation of antibodies for immunochemical assay and antibodies prepared therefrom
    Patent number: 4456553
    Abstract: The present invention relates to novel vitamin D.sub.3 derivatives which have a carboxyl group or its ester group at the 22-position, processes for the preparation thereof, and antigens, which comprise said vitamin D.sub.3 derivative and an immunogenic carrier material, to be used for the preparation of antibodies for enzymeimmunoassay or radioimmunoassay and antibodies obtained therefrom.The determination of such activated vitamin D.sub.3 compounds as 25-hydroxy vitamin D.sub.3, 24, 25-dihydroxy vitamin D.sub.3, etc. can be made satisfactorily according to the present invention.
    Type: Grant
    Filed: May 18, 1983
    Date of Patent: June 26, 1984
    Assignee: Teijin Limited
    Inventors: Jun-ichi Oshida, Osamu Nishikawa, Hideki Tsuruta, Toru Takeshita, Itaru Yamamoto, Kenji Ishimaru
  • 1.alpha., 25-dihydroxy-2.beta.-fluorovitamin D.sub.3
    Patent number: 4307025
    Abstract: The invention provides new derivatives of vitamin D.sub.3, specifically, 1.alpha.,25-dihydroxy-2.beta.-fluorocholecalciferol.The compound is characterized by vitamin D-like activity as measured by its ability to stimulate intestinal calcium transport, mobilization of calcium from bone, increase serum inorganic phosphorous and in their antirachitic activity. The compound, could, therefore, find ready application as a substitute for vitamin D in its various known applications and in the treatment of various metabolic bone diseases.
    Type: Grant
    Filed: February 17, 1981
    Date of Patent: December 22, 1981
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Nobuo Ikekawa, Yoko Tanaka, Masuo Morisaki, Jun-ichi Oshida
  • 1.alpha.-Hydroxy-2.beta.-fluorocholecalciferol
    Patent number: 4254045
    Abstract: The invention provides new derivatives of vitamin D.sub.3, specifically, 1.alpha.-hydroxy-2.beta.-fluorocholecalciferol.The compound is characterized by vitamin D-like activity as measured by its ability to stimulate intestinal calcium transport, mobilize calcium from bone, increase serum inorganic phosphorous and in their antirachitic acitivity. The compound could, therefore, find ready application as a substitute for vitamin D in its various known applications and in the treatment of various metabolic bone diseases.
    Type: Grant
    Filed: April 21, 1980
    Date of Patent: March 3, 1981
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Nobuo Ikekawa, Yoko Tanaka, Masuo Morisaki, Jun-ichi Oshida