Abstract: A monitoring system includes a monitoring control device, an image information providing device, and a client control device. The monitoring control device monitors infrastructure facilities and transmits statuses of the infrastructure facilities acquired on the basis of information input from a sensor to the image information providing device. The image information providing device generates original image information on the basis of the infrastructure facility statuses received from the monitoring control device. The client control device is connected to a display device and an operation device, receives information for designating a partial area of an entire image capable of being generated from the original image information from the operation device, transmits the received information to the image information providing device, and displays an image based on information received from the image information providing device on the display device.

Abstract: The present inventors have found microRNAs which are strongly associated with stabilization of NRF2 in tumors, and an object of the present invention is to provide means for utilizing such miRNAs for the diagnosis and treatment of cancer. The inventors conducted screening of 470 microRNAs in a microRNA library by use of HeLa cells. As a result, 8 miRNAs each exhibiting a large decrease in miRNA activity as compared with a control miRNA, and 8 miRNAs each exhibiting a large increase in miRNA activity as compared with a control miRNA, were identified. The inventors have found that the NRF2 activation in the living body, in particular tumor cells, can be detected by use of the thus-identified miRNAs, whereby malignancy of a tumor, or the like can be differentiated. The inventors have also found that a nucleic acid including a miRNA sequence associated with reduction in the aforementioned ARE activity can be used as a cancer therapeutic agent.

Abstract: An acoustic device includes a member which divides an ear canal of a user and an external space when being attached to an ear or the ear canal of the user, a memory that stores instructions, and a processor that executes the instructions. The instructions cause the processor to perform, acquiring a sound signal indicating a sound, applying a filter processing to the acquired sound signal, the filter processing being changed in accordance with a predetermined condition, and radiating the sound indicated by the sound signal applied with the filter processing to the ear canal.

Abstract: The present inventors have found microRNAs which are strongly associated with stabilization of NRF2 in tumors, and an object of the present invention is to provide means for utilizing such miRNAs for the diagnosis and treatment of cancer. The inventors conducted screening of 470 microRNAs in a microRNA library by use of HeLa cells. As a result, 8 miRNAs each exhibiting a large decrease in miRNA activity as compared with a control miRNA, and 8 miRNAs each exhibiting a large increase in miRNA activity as compared with a control miRNA, were identified. The inventors have found that the NRF2 activation in the living body, in particular tumor cells, can be detected by use of the thus-identified miRNAs, whereby malignancy of a tumor, or the like can be differentiated. The inventors have also found that a nucleic acid including a miRNA sequence associated with reduction in the aforementioned ARE activity can be used as a cancer therapeutic agent.

Abstract: An outer periphery coating method of honeycomb structure has coating steps where the honeycomb structure including a ring-like bulge portion is rotated; a coating member is brought into contact with a side surface of the honeycomb structure by pressing a side edge portion of a spatula via a rubber sheet, the coating member including the plate-like spatula in which a specific cut portion is formed in the one side edge portion and the side edge portion provided with the cut portion is an inclined surface inclined on a coating surface side, and the rubber sheet in which a cut is formed so that an end surface of the end portion is parallel to a back surface of the spatula when the end portion is bent along the side edge portion of the spatula; and a slurry coating material is supplied to the side surface of the honeycomb structure.

Abstract: A preparation containing [3-[2-[4-isopropyl-2-(4-trifluoromethyl)phenyl-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazol-6-yl]oxyacetic acid, [4-[3-[2-(4-trifluoromethyl)phenyl-4-isopropyl-5-thiazolyl]propionyl]-2-methylphenoxy]acetic acid or [4-[3-[2-(2-hydroxy-4-chlorophenyl)-5-isopropyl-4-oxazolyl]propionyl]-2-methylphenoxy]acetic acid, or a pharmacologically acceptable salt thereof as an active ingredient is used as an agent for promoting proliferation of meibomian gland epithelial cells or corneal epithelial cells, as well as a therapeutic agent for ocular diseases such as meibomian gland dysfunction, dry eye and the like.

Abstract: The present inventors have found microRNAs which are strongly associated with stabilization of NRF2 in tumors, and an object of the present invention is to provide means for utilizing such miRNAs for the diagnosis and treatment of cancer. The inventors conducted screening of 470 microRNAs in a microRNA library by use of HeLa cells. As a result, 8 miRNAs each exhibiting a large decrease in miRNA activity as compared with a control miRNA, and 8 miRNAs each exhibiting a large increase in miRNA activity as compared with a control miRNA, were identified. The inventors have found that the NRF2 activation in the living body, in particular tumor cells, can be detected by use of the thus-identified miRNAs, whereby malignancy of a tumor, or the like can be differentiated. The inventors have also found that a nucleic acid including a miRNA sequence associated with reduction in the aforementioned ARE activity can be used as a cancer therapeutic agent.

Abstract: A speed ratio control device for an automatic transmission of a vehicle calculate a minimum engine rotation speed based on a travel load, and sets a target speed ratio such that the engine rotation speed does not fall below the minimum engine rotation speed. If the travel load of the vehicle is equal to or greater than a predetermined value, a higher value is used for the minimum engine rotation speed compared to a case when the travel load of the vehicle is smaller than the predetermined value. Re-acceleration performance of the vehicle under a high travel load as in a case when the vehicle travels uphill while towing another vehicle is thereby improved.

Abstract: An object of the present invention is to provide an agent for promoting proliferation of a meibomian gland epithelial cell and a corneal epithelial cell, as well as provide an agent for treating an ocular disease such as meibomian gland dysfunction or evaporative dry eye. There are provided an agent for promoting proliferation of a meibomian gland epithelial cell or a corneal epithelial cell, containing a PPAR? or ? agonist as an active ingredient, as well as an agent for treating an ocular disease such as meibomian gland dysfunction or evaporative dry eye, containing a PPAR? or ? agonist as an active ingredient.

Abstract: A front subframe structure for an automotive vehicle comprises: a pair of right and left side members each provided with an arm support member for supporting a suspension arm is mounted; a cross member disposed between the left and right side members to couple together respective locations in the side members at each of which the arm support member is provided; and an oblique member extending from central portion of the cross member, in each of right and left directions of the vehicle and obliquely rearwardly and outwardly in the vehicle width direction, wherein each of the side members has a rear end joined to a rear portion of a respective one of the oblique members, and wherein the rear portion of the oblique member is provided with a tunnel-lower-frame coupling portion couplable to a tunnel lower frame, and a floor frame attaching portion attachable to a floor frame.

Abstract: A speed ratio control device for an automatic transmission of a vehicle calculate a minimum engine rotation speed based on a travel load, and sets a target speed ratio such that the engine rotation speed does not fall below the minimum engine rotation speed. If the travel load of the vehicle is equal to or greater than a predetermined value, a higher value is used for the minimum engine rotation speed compared to a case when the travel load of the vehicle is smaller than the predetermined value. Re-acceleration performance of the vehicle under a high travel load as in a case when the vehicle travels uphill while towing another vehicle is thereby improved.

Abstract: Provision of an agent for promoting proliferation of meibomian gland epithelial cells or corneal epithelial cells, and a therapeutic agent for ocular diseases such as meibomian gland dysfunction, dry eye and the like. A preparation containing [3-[2-[4-isopropyl-2-(4-trifluoromethyl)phenyl-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazol-6-yl]oxyacetic acid, [4-[3-[2-(4-trifluoromethyl)phenyl-4-isopropyl-5-thiazolyl]propionyl]-2-methylphenoxy]acetic acid or [4-[3-[2-(2-hydroxy-4-chlorophenyl)-5-isopropyl-4-oxazolyl]propionyl]-2-methylphenoxy]acetic acid, or a pharmacologically acceptable salt thereof as an active ingredient is used as an agent for promoting proliferation of meibomian gland epithelial cells or corneal epithelial cells, as well as a therapeutic agent for ocular diseases such as meibomian gland dysfunction, dry eye and the like.

Abstract: A front subframe structure for an automotive vehicle comprises: a pair of right and left side members each provided with an arm support member for supporting a suspension arm is mounted; a cross member disposed between the left and right side members to couple together respective locations in the side members at each of which the arm support member is provided; and an oblique member extending from central portion of the cross member, in each of right and left directions of the vehicle and obliquely rearwardly and outwardly in the vehicle width direction, wherein each of the side members has a rear end joined to a rear portion of a respective one of the oblique members, and wherein the rear portion of the oblique member is provided with a tunnel-lower-frame coupling portion couplable to a tunnel lower frame, and a floor frame attaching portion attachable to a floor frame.

Abstract: Provision of an agent for promoting proliferation of meibomian gland epithelial cells or corneal epithelial cells, and a therapeutic agent for ocular diseases such as meibomian gland dysfunction, dry eye and the like. A preparation containing [3-[2-[4-isopropyl-2-(4-trifluoromethyl)phenyl-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazol-6-yl]oxyacetic acid, [4-[3-[2-(4-trifluoromethyl)phenyl-4-isopropyl-5-thiazolyl]propionyl]-2-methylphenoxy]acetic acid or [4-[3-[2-(2-hydroxy-4-chlorophenyl)-5-isopropyl-4-oxazolyl]propionyl]-2-methylphenoxy]acetic acid, or a pharmacologically acceptable salt thereof as an active ingredient is used as an agent for promoting proliferation of meibomian gland epithelial cells or corneal epithelial cells, as well as a therapeutic agent for ocular diseases such as meibomian gland dysfunction, dry eye and the like.

Abstract: To provide a triazole compound which has remarkably excellent pesticidal activities.

Abstract: An outer periphery coating method of honeycomb structure has coating steps where the honeycomb structure including a ring-like bulge portion is rotated; a coating member is brought into contact with a side surface of the honeycomb structure by pressing a side edge portion of a spatula via a rubber sheet, the coating member including the plate-like spatula in which a specific cut portion is formed in the one side edge portion and the side edge portion provided with the cut portion is an inclined surface inclined on a coating surface side, and the rubber sheet in which a cut is formed so that an end surface of the end portion is parallel to a back surface of the spatula when the end portion is bent along the side edge portion of the spatula; and a slurry coating material is supplied to the side surface of the honeycomb structure.

Abstract: A bicycle wheel securing structure includes a bicycle fork, an adapter and a holding member. The bicycle fork has two axle support portions that are spaced apart for receiving a bicycle hub therebetween. The adapter is disposed in an adapter receiving bore in one of the axle support portions. The adapter includes a threaded axle mounting opening. The holding member is operatively coupled between the adapter and the one of the axle support portions with the adapter. The holding member prevents both rotational movement of the adapter with respect to the bicycle fork and axial movement of the adapter with respect to the bicycle fork along an axis of the axle mounting opening when the holding member is in a retaining position. The adapter is rotatable within the adapter receiving bore without moving axially with respect to the bicycle fork when the holding member is in a releasing position.

Abstract: A bicycle wheel securing structure includes a bicycle fork, an adapter and a holding member. The bicycle fork has two axle support portions that are spaced apart for receiving a bicycle hub therebetween. The adapter is disposed in an adapter receiving bore in one of the axle support portions. The adapter includes a threaded axle mounting opening. The holding member is operatively coupled between the adapter and the one of the axle support portions with the adapter. The holding member prevents both rotational movement of the adapter with respect to the bicycle fork and axial movement of the adapter with respect to the bicycle fork along an axis of the axle mounting opening when the holding member is in a retaining position. The adapter is rotatable within the adapter receiving bore without moving axially with respect to the bicycle fork when the holding member is in a releasing position.

Abstract: The present invention provides an ophthalmic composition comprising a hyperbranched polyester. The ophthalmic compositions may also comprise carbonic anhydrase inhibitors, wherein the hyperbranched polyester increases the aqueous solubility of the carbonic anhydrase inhibitor, and increases corneal permeation of the active agent. The ophthalmic compositions may also comprise non-ionic surfactants, such as PEG, Polysorbate, HPMC or HEC, and beta-blockers, such as Carteolol, Levobunolol, Betaxolol, Metipranolol, Timolol or Propranolol. The concentration of the hyperbranched polyester in the ophthalmic formulation should be less than or equal to 4% (w/v) in order to avoid any cytotoxic effects on human corneal cells and thus the eye irritation.

Abstract: To provide a triazole compound which has remarkably excellent pesticidal activities.