Abstract: The disclosure relates to the engineering of collagen-binding modification of masked therapeutic agents comprising one or more tumor-associated protease cleavage sites. Upon exposure to tumor-associated proteases in the tumor microenvironment, the polypeptide is cleaved, which unmasks the therapeutic agent, reducing off-target side effects and toxicity associated with systemic administration. Accordingly, aspects of the disclosure relate to a polypeptide comprising a therapeutic agent linked to a masking agent through a linker, wherein the linker comprises one or more tumor-associated protease cleavage sites, and wherein the masking agent blocks the association of the therapeutic agent to its therapeutic target, and further wherein the polypeptide is operatively linked to a collagen binding domain or a tumor-targeting agent.

Abstract: The methods and compositions described herein address the need in the art by providing peptides and polypeptides comprising a growth factor binding domain. In some embodiments, the peptides have an amino acid sequence that is at least 80% identical to one of SEQ ID NOS:1-7, 13-15, 49-50, or 66-70, or a fragment thereof; wherein the peptide is less than 300 amino acids in length.

Abstract: Aspects of the present disclosure provide methods and compositions for treatment of autoimmune disorders including, for example, multiple sclerosis and rheumatoid arthritis. Also disclosed are methods for promoting wound healing. Certain aspects are directed to antiinflammatory cytokines operatively linked to an albumin protein. Further aspects relate to methods for delivering an anti-inflammatory cytokine to a lymph node.

Abstract: The methods and compositions described herein address the need in the art by providing compositions and methods for a therapy with an antibody that is specifically targeted to and/or retained intra- or peri-tumorally, limiting systemic exposure and reducing side-effects. Accordingly, aspects of the disclosure relate to a composition comprising an immunotherapeutic antibody operatively linked to an extracellular matrix (ECM)-affinity peptide. An ECM-affinity peptide is one that has affinity for an extracellular matrix protein.

Abstract: The methods and compositions described herein address the need in the art by providing peptides and polypeptides comprising a growth factor binding domain. In some embodiments, the peptides have an amino acid sequence that is at least 80% identical to one of SEQ ID NOS:1-7, 13-15, 49-50, or 66-70, or a fragment thereof; wherein the peptide is less than 300 amino acids in length.

Abstract: The methods and compositions described herein address the need in the art by providing compositions and methods for a therapy with an antibody that is specifically targeted to and/or retained intra- or peri-tumorally, limiting systemic exposure and reducing side-effects. Accordingly, aspects of the disclosure relate to a composition comprising an immunotherapeutic antibody operatively linked to an extracellular matrix (ECM)-affinity peptide. An ECM-affinity peptide is one that has affinity for an extracellular matrix protein.

Abstract: This disclosure relates to tumor-targeted drug carriers that lead to improved anti-tumor efficacy by efficient delivery of a cytotoxic agent to the tumor microenvironment. Aspects of the disclosure relate to a polypeptide comprising an albumin or IgG Fc domain polypeptide operatively linked to a collagen binding domain. Further aspects relate to a composition comprising a polypeptide, nucleic acid, or cell of the disclosure.

Abstract: he disclosure relates to the engineering of collagen-binding modification of masked therapeutic agents comprising one or more tumor-associated protease cleavage sites. Upon exposure to tumor-associated proteases in the tumor microenvironment, the polypeptide is cleaved, which unmasks the therapeutic agent, reducing off-target side effects and toxicity associated with systemic administration. Accordingly, aspects of the disclosure relate to a polypeptide comprising a therapeutic agent linked to a masking agent through a linker, wherein the linker comprises one or more tumor-associated protease cleavage sites, and wherein the masking agent blocks the association of the therapeutic agent to its therapeutic target, and further wherein the polypeptide is operatively linked to a collagen binding domain or a tumor-targeting agent.

Abstract: Apparatuses, methods, and systems are disclosed herein to provide an information processing apparatus and a control method which do not cause a reduction in the output of radio waves when a human body is not approaching. A communication unit communicates with other devices wirelessly, a detection unit detects a physical quantity varying with the approach of an object, and a control unit causes the communication unit to reduce the output of radio waves when the amount of change in physical quantity exceeds a predetermined threshold value. When a predetermined member is in a position to approach a first chassis on which the communication unit and the detection unit are mounted, the control unit compensates for a change in physical quantity detected by the detection unit due to the approach of the member.

Abstract: The disclosure relates to the engineering of collagen-binding modification of anti-inflammatory agents using collagen-binding peptide (CBP) and vWF A3 to achieve targeted therapy for inflammatory diseases. Accordingly, embodiments of the disclosure relate to a composition comprising an anti-inflammatory agent operatively linked to an extracellular matrix (ECM)-affinity peptide. Also disclosed are cytokines and anti-inflammatory agents, such as CD200, linked to a serum protein and/or an ECM-affinity peptide. Further aspects of the disclosure relate to a method for treating an autoimmune or inflammatory condition in a subject comprising administering a composition of the disclosure to the subject.

Abstract: The methods and compositions described herein address the need in the art by providing compositions and methods for a therapy with a cytokine that is specifically targeted to and/or retained intra- or peri-tumorally, limiting systemic exposure and reducing side-effects. Accordingly, aspects of the disclosure relate to a composition comprising an immunotherapeutic antibody operatively linked to an extracellular matrix (ECM)-affinity peptide. An ECM-affinity peptide is one that has affinity for an extracellular matrix protein.

Abstract: The methods and compositions described herein address the need in the art by providing peptides and polypeptides comprising a growth factor binding domain. In some embodiments, the peptides have an amino acid sequence that is at least 80% identical to one of SEQ ID NOS:1-7, 13-15, 49-50, or 66-70, or a fragment thereof; wherein the peptide is less than 300 amino acids in length.

Abstract: Apparatuses, methods, and systems are disclosed herein to provide an information processing apparatus and a control method which do not cause a reduction in the output of radio waves when a human body is not approaching. A communication unit communicates with other devices wirelessly, a detection unit detects a physical quantity varying with the approach of an object, and a control unit causes the communication unit to reduce the output of radio waves when the amount of change in physical quantity exceeds a predetermined threshold value. When a predetermined member is in a position to approach a first chassis on which the communication unit and the detection unit are mounted, the control unit compensates for a change in physical quantity detected by the detection unit due to the approach of the member.

Abstract: An electronic apparatus includes a floating section which has a speaker part and a first box part provided with a first cavity portion functioning as a back chamber of the speaker part and is fixed to a main body chassis in a floatable state inside the main body chassis, a rigid section which has a second box part provided with a second cavity portion and which is rigidly fixed to the main body chassis inside the main body chassis and formed with an antenna on at least a part of the second box part, and a connecting pipe which connects the first box part and the second box part through a vibration buffer part and communicates the first cavity portion and the second cavity portion with each other.

Abstract: An electronic apparatus includes a floating section which has a speaker part and a first box part provided with a first cavity portion functioning as a back chamber of the speaker part and is fixed to a main body chassis in a floatable state inside the main body chassis, a rigid section which has a second box part provided with a second cavity portion and which is rigidly fixed to the main body chassis inside the main body chassis and formed with an antenna on at least a part of the second box part, and a connecting pipe which connects the first box part and the second box part through a vibration buffer part and communicates the first cavity portion and the second cavity portion with each other.

Abstract: The methods and compositions described herein address the need in the art by providing compositions and methods for a therapy with an antibody that is specifically targeted to and/or retained intra- or peri-tumorally, limiting systemic exposure and reducing side-effects. Accordingly, aspects of the disclosure relate to a composition comprising an immunotherapeutic antibody operatively linked to an extracellular matrix (ECM)-affinity peptide. An ECM-affinity peptide is one that has affinity for an extracellular matrix protein.

Abstract: In an optical sensor, a detecting part includes detecting elements, and a light-shielding portion providing directional characteristics of light to the detecting elements such that the detecting elements indicate different intensities of light received in a specified direction. A signal processing part has an adjustment value for processing detection signals. The adjustment value is set as follows. Based on information of an inclination angle of a window glass of a vehicle to which the detecting part is attached, from the detecting elements, a detecting element having a directional characteristic of light suitable for the inclination angle is selected. The adjustment value is then set so as to coincide a signal value of a detection signal of the selected detecting element with a target value, when the detecting part is irradiated with light in a predetermined direction in a state where the detecting part is inclined at the inclination angle.

Abstract: In an optical sensor, a detecting part includes detecting elements, and a light-shielding portion providing directional characteristics of light to the detecting elements such that the detecting elements indicate different intensities of light received in a specified direction. A signal processing part has an adjustment value for processing detection signals. The adjustment value is set as follows. Based on information of an inclination angle of a window glass of a vehicle to which the detecting part is attached, from the detecting elements, a detecting element having a directional characteristic of light suitable for the inclination angle is selected. The adjustment value is then set so as to coincide a signal value of a detection signal of the selected detecting element with a target value, when the detecting part is irradiated with light in a predetermined direction in a state where the detecting part is inclined at the inclination angle.

Abstract: An organic electroluminescent device includes an anode, an emission layer, an anode-side hole transport layer between the anode and the emission layer, the anode-side hole transport layer including an anode-side hole transport material doped with an electron accepting material, a middle hole transport layer between the anode-side hole transport layer and the emission layer, the middle hole transport layer including a middle hole transport material, and an emission layer-side hole transport layer between the middle hole transport layer and the emission layer, the emission layer-side hole transport layer being adjacent to the emission layer. The emission layer-side hole transport layer includes an emission layer-side hole transport material represented by Formula 1. The organic electroluminescent device may have improved emission efficiency and emission life.

Abstract: A projection optical system (6) comprises a relay optical system (61), a PBS prism (71), and two projection lenses (81). The image light beam from a DMD (5) enters the PBS prism (71) via the relay optical system (61), is polarization-split there, and is directed to a screen by means of the two projection lenses (81). Displaying an image by means of the DMD (5) is controlled while the polarized states of the light beams produced by the polarization split by means of the PBS prism (71) are controlled. Thereby, a three-dimensionally viewable image and a high-resolution image created by pixel-offset can be projected. Since the relay optical system (61) is provided, the lens backs of the projection lenses (81) can be shortened, and the projection lenses (81) and further the projection optical system (6) can be made compact.