Patents by Inventor Jun Ishihara

Jun Ishihara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240114908
    Abstract: An object of the present invention is to provide a 2,6-dioxo-3,6-dihydropyrimidine compound that has excellent bactericidal and antimicrobial activity, has excellent safety, and can be industrially favorably synthesized, and an agricultural and horticultural fungicide, a nematicide, and an antifungal agent for use in medicine/animals that contain the compound as an active ingredient.
    Type: Application
    Filed: October 26, 2020
    Publication date: April 11, 2024
    Applicant: Nippon Soda Co., Ltd.
    Inventors: Takaaki TERANISHI, Raito KUWAHARA, Yohei MUNEI, Hajime SHIMOMURA, Tatsuhiro KAWASAKI, Takuma ISHIHARA, Jun IWATA, Tomoyuki SAIGA, Chihiro NISHINO
  • Publication number: 20240100504
    Abstract: A synthetic adsorbent, where a maximum value of a differential pore volume under a pressure condition of 0.5 to 30.0 psia is greater than 0.05 mL/g. A method of measuring the differential pore volume includes reducing a pressure in a sample container where the synthetic adsorbent that has been dried is placed to 10 Pa or less, mercury is degassed by reducing the pressure to 10 Pa or less, and the sample container is filled with the mercury at a pressure of 0.5 psia, measuring a mercury intrusion amount when the pressure in the sample container filled with the mercury is increased from 0.5 to 30.0 psia, and calculating the differential pore volume by dividing an amount of an increase in the mercury intrusion amount when a first-stage pressure calculated based on the mercury intrusion amount measured in the measuring is increased, by a measured amount of the synthetic adsorbent.
    Type: Application
    Filed: December 8, 2023
    Publication date: March 28, 2024
    Applicants: Mitsubishi Chemical Corporation, Kyowa Kirin Co., Ltd.
    Inventors: Yoshiya TASHIRO, Shouhei OHARA, Jun TAKEHARA, Takashi ISHIHARA, Shinsuke KIKUCHI
  • Publication number: 20240092867
    Abstract: The methods and compositions described herein address the need in the art by providing peptides and polypeptides comprising a growth factor binding domain. In some embodiments, the peptides have an amino acid sequence that is at least 80% identical to one of SEQ ID NOS:1-7, 13-15, 49-50, or 66-70, or a fragment thereof; wherein the peptide is less than 300 amino acids in length.
    Type: Application
    Filed: July 13, 2023
    Publication date: March 21, 2024
    Applicants: The University of Chicago, Imperial College Innovations Limited
    Inventors: Jeffrey A. HUBBELL, Anna M. RANDI, Jun ISHIHARA, Ako ISHIHARA, Priscilla BRIQUEZ, Richard STARKE
  • Publication number: 20240052006
    Abstract: Aspects of the present disclosure provide methods and compositions for treatment of autoimmune disorders including, for example, multiple sclerosis and rheumatoid arthritis. Also disclosed are methods for promoting wound healing. Certain aspects are directed to antiinflammatory cytokines operatively linked to an albumin protein. Further aspects relate to methods for delivering an anti-inflammatory cytokine to a lymph node.
    Type: Application
    Filed: September 24, 2021
    Publication date: February 15, 2024
    Applicant: THE UNIVERSITY OF CHICAGO
    Inventors: Jeffrey A HUBBELL, Eiji YUBA, Elyse WATKINS, Jun ISHIHARA, Ako ISHIHARA, Erica BUDINA, Abigail LAUTERBACH
  • Publication number: 20230377764
    Abstract: The methods and compositions described herein address the need in the art by providing compositions and methods for a therapy with an antibody that is specifically targeted to and/or retained intra- or peri-tumorally, limiting systemic exposure and reducing side-effects. Accordingly, aspects of the disclosure relate to a composition comprising an immunotherapeutic antibody operatively linked to an extracellular matrix (ECM)-affinity peptide. An ECM-affinity peptide is one that has affinity for an extracellular matrix protein.
    Type: Application
    Filed: February 3, 2023
    Publication date: November 23, 2023
    Applicant: The University of Chicago
    Inventors: Jeffrey A. HUBBELL, Jun ISHIHARA, Ako ISHIHARA, Kazuto FUKUNAGA, Melody SWARTZ
  • Patent number: 11732029
    Abstract: The methods and compositions described herein address the need in the art by providing peptides and polypeptides comprising a growth factor binding domain. In some embodiments, the peptides have an amino acid sequence that is at least 80% identical to one of SEQ ID NOS:1-7, 13-15, 49-50, or 66-70, or a fragment thereof; wherein the peptide is less than 300 amino acids in length.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: August 22, 2023
    Assignees: The University Chicago, Imperial College Innovations Limited
    Inventors: Jeffrey A. Hubbell, Anna M. Randi, Jun Ishihara, Ako Ishihara, Priscilla Briquez, Richard Starke
  • Patent number: 11574747
    Abstract: The methods and compositions described herein address the need in the art by providing compositions and methods for a therapy with an antibody that is specifically targeted to and/or retained intra- or peri-tumorally, limiting systemic exposure and reducing side-effects. Accordingly, aspects of the disclosure relate to a composition comprising an immunotherapeutic antibody operatively linked to an extracellular matrix (ECM)-affinity peptide. An ECM-affinity peptide is one that has affinity for an extracellular matrix protein.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: February 7, 2023
    Assignee: The University of Chicago
    Inventors: Jeffrey A. Hubbell, Jun Ishihara, Ako Ishihara, Kazuto Fukunaga, Melody Swartz
  • Publication number: 20220298225
    Abstract: This disclosure relates to tumor-targeted drug carriers that lead to improved anti-tumor efficacy by efficient delivery of a cytotoxic agent to the tumor microenvironment. Aspects of the disclosure relate to a polypeptide comprising an albumin or IgG Fc domain polypeptide operatively linked to a collagen binding domain. Further aspects relate to a composition comprising a polypeptide, nucleic acid, or cell of the disclosure.
    Type: Application
    Filed: June 3, 2020
    Publication date: September 22, 2022
    Applicant: The University of Chicago
    Inventors: Jeffrey A. HUBBELL, Jun ISHIHARA, Koichi SASAKI
  • Publication number: 20220281936
    Abstract: he disclosure relates to the engineering of collagen-binding modification of masked therapeutic agents comprising one or more tumor-associated protease cleavage sites. Upon exposure to tumor-associated proteases in the tumor microenvironment, the polypeptide is cleaved, which unmasks the therapeutic agent, reducing off-target side effects and toxicity associated with systemic administration. Accordingly, aspects of the disclosure relate to a polypeptide comprising a therapeutic agent linked to a masking agent through a linker, wherein the linker comprises one or more tumor-associated protease cleavage sites, and wherein the masking agent blocks the association of the therapeutic agent to its therapeutic target, and further wherein the polypeptide is operatively linked to a collagen binding domain or a tumor-targeting agent.
    Type: Application
    Filed: July 24, 2020
    Publication date: September 8, 2022
    Applicant: The University of Chicago
    Inventors: Jeffrey HUBBELL, Jun ISHIHARA, Juan MENDOZA, Aslan MANSUROV
  • Patent number: 11425644
    Abstract: Apparatuses, methods, and systems are disclosed herein to provide an information processing apparatus and a control method which do not cause a reduction in the output of radio waves when a human body is not approaching. A communication unit communicates with other devices wirelessly, a detection unit detects a physical quantity varying with the approach of an object, and a control unit causes the communication unit to reduce the output of radio waves when the amount of change in physical quantity exceeds a predetermined threshold value. When a predetermined member is in a position to approach a first chassis on which the communication unit and the detection unit are mounted, the control unit compensates for a change in physical quantity detected by the detection unit due to the approach of the member.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: August 23, 2022
    Assignee: Lenovo (Singapore) PTE. LTD.
    Inventors: Shigekazu Hawaka, Jun Ishihara, Ke Ma
  • Publication number: 20220118089
    Abstract: The disclosure relates to the engineering of collagen-binding modification of anti-inflammatory agents using collagen-binding peptide (CBP) and vWF A3 to achieve targeted therapy for inflammatory diseases. Accordingly, embodiments of the disclosure relate to a composition comprising an anti-inflammatory agent operatively linked to an extracellular matrix (ECM)-affinity peptide. Also disclosed are cytokines and anti-inflammatory agents, such as CD200, linked to a serum protein and/or an ECM-affinity peptide. Further aspects of the disclosure relate to a method for treating an autoimmune or inflammatory condition in a subject comprising administering a composition of the disclosure to the subject.
    Type: Application
    Filed: February 25, 2020
    Publication date: April 21, 2022
    Applicant: The University of Chicago
    Inventors: Jeffrey A. HUBBELL, Kiyomitsu KATSUMATA, Ako ISHIHARA, Jun ISHIHARA, Aslan MANSUROV
  • Publication number: 20210094995
    Abstract: The methods and compositions described herein address the need in the art by providing compositions and methods for a therapy with a cytokine that is specifically targeted to and/or retained intra- or peri-tumorally, limiting systemic exposure and reducing side-effects. Accordingly, aspects of the disclosure relate to a composition comprising an immunotherapeutic antibody operatively linked to an extracellular matrix (ECM)-affinity peptide. An ECM-affinity peptide is one that has affinity for an extracellular matrix protein.
    Type: Application
    Filed: March 5, 2019
    Publication date: April 1, 2021
    Inventors: Jeffrey A. HUBBELL, Jun ISHIHARA, Ako ISHIHARA, Koichi SASAKI, Melody SWARTZ, Aslan MANSUROV
  • Publication number: 20210040179
    Abstract: The methods and compositions described herein address the need in the art by providing peptides and polypeptides comprising a growth factor binding domain. In some embodiments, the peptides have an amino acid sequence that is at least 80% identical to one of SEQ ID NOS:1-7, 13-15, 49-50, or 66-70, or a fragment thereof; wherein the peptide is less than 300 amino acids in length.
    Type: Application
    Filed: November 13, 2018
    Publication date: February 11, 2021
    Inventors: Jeffrey A. HUBBELL, Anna M. RANDI, Jun ISHIHARA, Ako ISHIHARA, Priscilla BRIQUEZ, Richard STARKE
  • Publication number: 20200389845
    Abstract: Apparatuses, methods, and systems are disclosed herein to provide an information processing apparatus and a control method which do not cause a reduction in the output of radio waves when a human body is not approaching. A communication unit communicates with other devices wirelessly, a detection unit detects a physical quantity varying with the approach of an object, and a control unit causes the communication unit to reduce the output of radio waves when the amount of change in physical quantity exceeds a predetermined threshold value. When a predetermined member is in a position to approach a first chassis on which the communication unit and the detection unit are mounted, the control unit compensates for a change in physical quantity detected by the detection unit due to the approach of the member.
    Type: Application
    Filed: June 5, 2020
    Publication date: December 10, 2020
    Inventors: Shigekazu Hawaka, Jun Ishihara, Ke Ma
  • Patent number: 10728637
    Abstract: An electronic apparatus includes a floating section which has a speaker part and a first box part provided with a first cavity portion functioning as a back chamber of the speaker part and is fixed to a main body chassis in a floatable state inside the main body chassis, a rigid section which has a second box part provided with a second cavity portion and which is rigidly fixed to the main body chassis inside the main body chassis and formed with an antenna on at least a part of the second box part, and a connecting pipe which connects the first box part and the second box part through a vibration buffer part and communicates the first cavity portion and the second cavity portion with each other.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: July 28, 2020
    Assignee: Lenovo (Singapore) Pte. Ltd.
    Inventors: Jun Ishihara, Shigekazu Hawaka
  • Publication number: 20200186900
    Abstract: An electronic apparatus includes a floating section which has a speaker part and a first box part provided with a first cavity portion functioning as a back chamber of the speaker part and is fixed to a main body chassis in a floatable state inside the main body chassis, a rigid section which has a second box part provided with a second cavity portion and which is rigidly fixed to the main body chassis inside the main body chassis and formed with an antenna on at least a part of the second box part, and a connecting pipe which connects the first box part and the second box part through a vibration buffer part and communicates the first cavity portion and the second cavity portion with each other.
    Type: Application
    Filed: April 26, 2019
    Publication date: June 11, 2020
    Applicant: Lenovo (Singapore) Pte. Ltd.
    Inventors: Jun Ishihara, Shigekazu Hawaka
  • Publication number: 20200123228
    Abstract: The methods and compositions described herein address the need in the art by providing compositions and methods for a therapy with an antibody that is specifically targeted to and/or retained intra- or peri-tumorally, limiting systemic exposure and reducing side-effects. Accordingly, aspects of the disclosure relate to a composition comprising an immunotherapeutic antibody operatively linked to an extracellular matrix (ECM)-affinity peptide. An ECM-affinity peptide is one that has affinity for an extracellular matrix protein.
    Type: Application
    Filed: April 20, 2018
    Publication date: April 23, 2020
    Inventors: Jeffrey A. HUBBELL, Jun ISHIHARA, Ako ISHIHARA, Kazuto FUKUNAGA, Melody SWARTZ
  • Patent number: 10228281
    Abstract: In an optical sensor, a detecting part includes detecting elements, and a light-shielding portion providing directional characteristics of light to the detecting elements such that the detecting elements indicate different intensities of light received in a specified direction. A signal processing part has an adjustment value for processing detection signals. The adjustment value is set as follows. Based on information of an inclination angle of a window glass of a vehicle to which the detecting part is attached, from the detecting elements, a detecting element having a directional characteristic of light suitable for the inclination angle is selected. The adjustment value is then set so as to coincide a signal value of a detection signal of the selected detecting element with a target value, when the detecting part is irradiated with light in a predetermined direction in a state where the detecting part is inclined at the inclination angle.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: March 12, 2019
    Assignee: DENSO CORPORATION
    Inventors: Jun Ishihara, Takamitsu Ookura
  • Publication number: 20170363466
    Abstract: In an optical sensor, a detecting part includes detecting elements, and a light-shielding portion providing directional characteristics of light to the detecting elements such that the detecting elements indicate different intensities of light received in a specified direction. A signal processing part has an adjustment value for processing detection signals. The adjustment value is set as follows. Based on information of an inclination angle of a window glass of a vehicle to which the detecting part is attached, from the detecting elements, a detecting element having a directional characteristic of light suitable for the inclination angle is selected. The adjustment value is then set so as to coincide a signal value of a detection signal of the selected detecting element with a target value, when the detecting part is irradiated with light in a predetermined direction in a state where the detecting part is inclined at the inclination angle.
    Type: Application
    Filed: January 28, 2016
    Publication date: December 21, 2017
    Inventors: Jun ISHIHARA, Takamitsu OOKURA
  • Publication number: 20160163982
    Abstract: An organic electroluminescent device includes an anode, an emission layer, an anode-side hole transport layer between the anode and the emission layer, the anode-side hole transport layer including an anode-side hole transport material doped with an electron accepting material, a middle hole transport layer between the anode-side hole transport layer and the emission layer, the middle hole transport layer including a middle hole transport material, and an emission layer-side hole transport layer between the middle hole transport layer and the emission layer, the emission layer-side hole transport layer being adjacent to the emission layer. The emission layer-side hole transport layer includes an emission layer-side hole transport material represented by Formula 1. The organic electroluminescent device may have improved emission efficiency and emission life.
    Type: Application
    Filed: December 2, 2015
    Publication date: June 9, 2016
    Inventors: Jun Ishihara, Ichinori Takada