Abstract: The present invention discloses a polymerizable compound, a liquid crystal composition comprising the polymerizable compound, and a liquid crystal display device. The polymerizable compound is a compound represented by the following formula I, wherein Sp represents a single bond or a C1-C5 linear, branched or cyclic alkyl group, and the Sp groups are not both single bonds, wherein any one or more non-adjacent —CH2— can be replaced by —O—, —S—, —CO—, —CH2O—, —OCH2—, —COO—, —OOC—, or an acrylate group in such a manner that O- or S-atoms are not directly connected with each other, one or more H atoms can be independently replaced by F, C1, or G3, and at least one H atom is replaced by G3; G3 represents a C1-C7 tertiary alcohol structure; and X represents —CH2—, —O—, or —S—. In particular, the polymerizable compound has the advantages of good diffusivity, high stability of the formed polymer, and low residue after a UV process.

Abstract: The present invention provides compounds with the structure of formula (I) that can be used as KRAS inhibitors, pharmaceutical compositions containing these compounds, methods for preparing these compounds, and uses of these compounds in the treatment of cancer.

Abstract: A charged particle beam detector may include a plurality of detector segments designed to accommodate a field of view (FOV) of a charged particle beam apparatus. A first detector segment may form a first detector region configured to capture emitted charged particles for a smaller FOV size. A second detector segment may surround the first detector segment to form a second detector region configured to capture emitted charged particles under larger FOV size. The first detector region may have a lower noise component due to reduced junction capacitance in the smaller detection surface area.

Abstract: A micro-thrust and micro-impulse application device and method generates micro-thrust to a target by light pressure action from laser reflection. The device comprises a laser, a laser adjustment device, a beam splitter, a shutter, a reflector, and a laser power meter. Laser beam is generated by laser, adjusted by laser adjustment device, and divided into two paths by beam splitter. Laser in one path is measured at laser power meter; power measured determines magnitude for micro-thrust. In another path, it irradiates on the reflector on the target via shutter for generating micro-thrust. Light reflected by the reflector arrives at another laser power meter. Power of two laser paths are measured in real time by two laser power meters, acting micro-thrust is calculated by combining parameters including reflectivity and incident angle of laser irradiating the reflector, and light output power of the laser is adjusted in real time.

Abstract: Systems and methods of observing a sample using a charged-particle beam apparatus in voltage contrast mode are disclosed. The charged-particle beam apparatus comprises a charged-particle source, an optical source, a charged-particle detector configured to detect charged particles, and a controller having circuitry configured to apply a first signal to cause the optical source to generate the optical pulse, apply a second signal to the charged-particle detector to detect the second plurality of charged particles, and adjust a time delay between the first and the second signals. In some embodiments, the controller having circuitry may be further configured to acquire a plurality of images of a structure, to determine an electrical characteristic of the structure based on the rate of gray level variation of the plurality of images of the structure, and to simulate, using a model, a physical characteristic of the structure based on the determined electrical characteristic.

Abstract: Methods, systems, and devices for performing read operations during suspend modes are described. A memory system may receive one or more read commands while performing program operations and may store the read commands to respective queues associated with planes of a logical unit number (LUN) of the memory system. Once a threshold quantity of read commands have been received (e.g., stored to the queues), the memory system may suspend the ongoing program operations. The memory system may perform operations associated with the queued read commands when the program operations are suspended, and may resume the program operations after completion of the read operations.

Abstract: The present invention relates to a nucleic acid construct comprising a UTR and use thereof. Specifically, the UTR can significantly improve the expression efficiency of a target gene in the nucleic acid construct. The nucleic acid construct may comprise a nucleic acid sequence expressing, for example, a human hepatocyte growth factor (hHGF), and can be used in a gene therapy for serious lower limb ischemia, diabetic foot, and other diseases.

Abstract: Provided herein is a dumbbell, including a dumbbell rod assembly and dumbbell plates, where the dumbbell rod assembly includes a dumbbell rod, each of the dumbbell plates is provided with a second clamping portion, the middle of the dumbbell rod is sleeved with a handle, two sides of the dumbbell rod are provided with hanging assemblies respectively, each of the hanging assemblies includes a plurality of lock discs, each of the lock discs is provided with a first clamping portion and a stand column, and the second clamping portion of the dumbbell plate moves relatively between the stand column and the first clamping portion of the lock disc and is clamped with the first clamping portion.

Abstract: Secure data tunnels are established with a plurality of edge points on a plurality of local enterprise networks. At some point, request packets are received in real-time over the first secure tunnel from a first edge point that has encapsulated the request packets. The request packets originate from a malicious actor attacking a projected decoy. Response packets generated from high-fidelity processing of the request packets are encapsulated by the first decoy device and routing to the first secure data tunnel. The response packets are decapsulated and forwarded by edge points back to the malicious actor.

Abstract: A near-eye display comprises a display panel (e.g., a liquid crystal display (LCD) panel, an organic light emitting diode (OLED) display panel, or a light emitting diode (LED) display panel) configured to generate a display image, display optics configured to project the display image to a user, and an color filter or an electrically switchable layer on or near the display optics. The transmission spectra of the color filter match the light emission spectra of the display panel such that the color filter may transmit display light while blocking light outside of the passbands. The electrically switchable layer can be turned on to transmit display light and can be turned off to block ambient light.

Abstract: A charged particle beam system may include a primary source, a secondary source, and a controller. The primary source may be configured to emit a charged particle beam along an optical axis onto a region of a sample. The secondary source may be configured to irradiate the region of the sample. The controller may be configured to control the charged particle beam system to change a parameter of an output of the secondary source. A method of imaging may include emitting a charged particle beam onto a region of a sample, irradiating the region of the sample with a secondary source, and changing a parameter of an output of the secondary source. A method of detecting defects may include inspecting a sample, generating a first defect distribution, and generating a second defect distribution.

Abstract: Provided are a ternary composite material having a NiO nanosheet/bimetallic CeCuOx microsheet core-shell structure, and a preparation method therefor, and an application thereof. CeCuOx has a large specific surface area and high stability. A NiO/CeCuOx core-shell structured composite material catalyst is prepared by growing NiO nanosheets on the surface of CeCuOx by low-temperature hydrothermal treatment and heat treatment. The bimetallic CeCuOx microsheet shows better catalytic performance for toluene than monometallic oxides, i.e., copper oxide and cerium oxide. The further growth of the NiO nanosheets having different concentrations effectively improves catalytic activity. A 3Ni/CeCuOx catalyst can realize complete catalysis of toluene at 210° C.

Abstract: An electrochemical device includes an electrode assembly and a housing for accommodating the electrode assembly. The housing includes a first housing body and a second housing body fixedly connected to the first housing body. A notch is provided on at least one of the first housing body or the second housing body. The electrode assembly includes a tab. The tab protrudes out of the housing from the notch. The notch is filled with a sealing material.

Abstract: A deception as a service (DaaS) system configures a decoy to generate a decoy instance, and projects the decoy instance into a user network. The DaaS system receives, by the decoy in the deception system, from an edge point in the user network, an attack request on the decoy instance by an attacker, generates an attack response by the decoy based at least in part on the attack request; and sends the attack response to the attacker. The attack response may include erroneous information, such as a lure file or lure credentials.

Abstract: Systems and methods of observing a sample using a charged-particle beam apparatus in voltage contrast mode are disclosed. The charged-particle beam apparatus comprises a charged-particle source, an optical source, a charged-particle detector configured to detect charged particles, and a controller having circuitry configured to apply a first signal to cause the optical source to generate the optical pulse, apply a second signal to the charged-particle detector to detect the second plurality of charged particles, and adjust a time delay between the first and the second signals. In some embodiments, the controller having circuitry may be further configured to acquire a plurality of images of a structure, to determine an electrical characteristic of the structure based on the rate of gray level variation of the plurality of images of the structure, and to simulate, using a model, a physical characteristic of the structure based on the determined electrical characteristic.

Abstract: The present invention relates to a method for treating a tumor such as a tumor with a KRAS mutation. In the method, a compound 2-fluoro-5-methoxy-4-[(4-(2-methyl-3-oxo-2,3-dihydro-1H-isoindole-4-oxy)-5-trifluoromethyl-pyrimidine-2-yl)amino]-N-(1-methyl-piperidine-4-yl)benzamide or a pharmaceutically acceptable salt thereof is used, which can be administered alone or in combination with a KRAS inhibitor and/or an MEK inhibitor.

Abstract: A device management system, method and apparatus are disclosed. The device management method comprises: sending, in response to a borrow and return request, an unlocking instruction to an electromagnetic lock configured for a device management cabinet, wherein the electromagnetic lock unlocks the device management cabinet in response to the unlocking instruction; receiving charging state information of a target device storage unit that is returned by the device management cabinet, wherein said device is stored in the target device storage unit; receiving lock state data of the device management cabinet that is sent by the electromagnetic lock, and acquiring electric quantity state information of said device; and generating, according to the charging state information, the electric quantity state information and the lock state data, borrow and return information of said device.

Abstract: The use of SmABCG2 gene in the cultivation of male sterile line in eggplant is provided, belonging to the field of genetic engineering. In the present disclosure, on the basis of CRISPR/Cas9 technology, the SmABCG2 gene is edited using an sgRNA having a nucleotide sequence as shown in SEQ ID NO: 5, or a combination of sgRNAs as shown in SEQ ID NOs. 5 and 6, to knock out the SmABCG2 gene and obtain male sterile lines in eggplant. Due to the stable sterility of these eggplant lines in the northern semi-arid region of China, male sterile lines with different genetic backgrounds could be created, and the male sterile lines can be applied to crossbreeding and seed production.

Abstract: A power supplement-based controllable landing method for a parachute landing target. The method includes: acquiring motion information of a parachute landing target; a power system (5; 5a-5h) meeting the parachute landing target, and being connected to the parachute landing target; and according to task requirements, reasonably allocating power resources to the power system (5; 5a-5h) and the parachute landing target in a power recombination manner, and driving the parachute landing target to move to a desired position, or to land in a desired state.

Abstract: A method for the low-temperature heat treatment of toluene by using a composite material having a ternary NiO nanosheet @ bimetallic CeCuOx microsheet core-shell structure. The composite material having the ternary NiO nanosheet @ bimetallic CeCuOx microsheet core-shell structure is placed in an environment containing toluene, and is heated at a low temperature to complete the treatment of toluene. The use of precious metal particles loading is avoided for the catalyst, and the costs of materials is thus greatly reduced. Moreover, nickel oxide grows on CeCuOx microsheet nanosheets. The preparation process is relatively simple, and the catalytic performance on toluene is excellent. Therefore, the method has high economical practicability and research value. The 3Ni/CeCuOx catalyst may completely catalyze toluene at 210° C., which has great research significance and certain application prospects for the actual solution of toluene polluted gas in the air environment.