Abstract: The present disclosure provides variant type V CRISPR/Cas effector polypeptides, fusion polypeptides comprising the variant type V CRISPR/Cas effector polypeptides, and nucleic acids comprising nucleotide sequences encoding the variant polypeptides and fusion polypeptides. The present disclosure provides methods of binding, or binding and nicking, a target nucleic acid, using a variant type V CRISPR/Cas effector polypeptide of the present disclosure. The present disclosure provides methods of detecting a single-stranded DNA, using a variant type V CRISPR/Cas effector polypeptide of the present disclosure.

Abstract: A bogie includes a bogie frame, a first running wheel and a second running wheel, at least one driving device, a first horizontal wheel, a second horizontal wheel, a first horizontal safety wheel connected to the first horizontal wheel and moving in synchronization with the first horizontal wheel, and a second horizontal safety wheel connected to the second horizontal wheel and moving in synchronization with the second horizontal wheel. The bogie frame has a straddle recess suitable for straddling a rail. The first running wheel and the second running wheel are pivotably mounted onto the bogie frame respectively and are coaxially spaced apart. The at least one driving device is mounted onto the bogie frame and located between the first running wheel and the second running wheel to drive the first running wheel and the second running wheel.

Abstract: The present disclosure provides an engineered Hansenula fungus that efficiently expresses CA10 (Coxsackievirus A10) virus-like particles and uses thereof. The engineered fungus includes a recombinant vector carrying the P1 and 3CD genes of the CA10 virus optimized according to preferred codons of Hansenula. The present disclosure also provides a preparation method for CA10 virus-like particles and vaccines prepared therefrom.

Abstract: Provided herein are radiopharmaceutical compositions and uses thereof. The radiopharmaceutical compositions can comprise one or more stabilizing agents, an aqueous vehicle, and a conjugate that comprises a targeting ligand and a radionuclide bound to a metal chelator. The targeting ligand can be a small molecule compound or a peptide such as a monocyclic peptide. The targeting ligand can be configured to bind with a tumor target. The stabilizing agent can comprise a radiolysis stabilizer, a free metal chelator, and/or a pH stabilizer. Further provided herein are methods of preparing the radiopharmaceutical compositions and methods of treating cancer by administering the described radiopharmaceutical compositions.

Abstract: The present disclosure provides a training and application method of a multi-layer neural network model, apparatus and a storage medium. In a forward propagation of the multi-layer neural network model, the number of input feature maps is expanded and a data computation is performed by using the expanded input feature maps.

Abstract: A cracking reaction device includes a preheating section, a lightening section, a reduced-pressure gasification section and a cracking section that are connected sequentially. A method for producing olefins by cracking involves pressurizing a cracking feedstock and water; subjecting the pressurized cracking feedstock and water to a first heating; subjecting the first heated cracking feedstock and water to a second heating and lightening the cracking feedstock in the presence of water to obtain a lightened mixture; gasifying the lightened mixture under a reduced pressure and subjected to a third heating to obtain a third heated mixture; and cracking the third heated mixture at a cracking temperature in the presence of steam to obtain a cracked product containing olefins.

Abstract: The present disclosure provides a training and application method of a multi-layer neural network model, apparatus and a storage medium. In a forward propagation of the multi-layer neural network model, the number of input feature maps is expanded and a data computation is performed by using the expanded input feature maps.

Abstract: The present invention relates to the field of fluid heat transfer, and discloses a heat transfer enhancement pipe as well as a cracking furnace and an atmospheric and vacuum heating furnace including the same. The heat transfer enhancement pipe (1) includes a pipe body (10) of tubular shape having an inlet (100) for entering of a fluid and an outlet (101) for said fluid to flow out; internal wall of the pipe body (10) is provided with a fin (11) protruding towards interior of the pipe body (10), wherein the fin (11) has one or more fin sections extending spirally in the axial direction of the pipe body (10), and each fin section has a first end surface facing the inlet (100) and a second end surface facing the outlet (101), at least one of the first end surface and the second end surface of at least one of the rib sections is formed as a transition surface along spirally extending direction.

Abstract: The present disclosure provides antibody-drug conjugate structures, that include cleavable linker having a sulfatase-cleavable moiety. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.

Abstract: An antenna for RF communications includes a plurality of phase shifters, with each phase shifter having a phase shifter cavity. The phase shifter cavities of the plurality of phase shifters are disposed in parallel, with two adjacent phase shifter cavities connected through fusion welding, and the plurality of phase shifter cavities form a reflection plate of the antenna.

Abstract: A rail vehicle includes a bogie, multiple wheels, a chassis, and a carriage. The wheels are disposed on the bogie. The chassis is disposed on the bogie and connected to the bogie through a first suspension. The carriage is disposed on the chassis and connected to the chassis through a second suspension.

Abstract: Described herein are radiotherapeutics that target tumor cells expressing the neuropeptide Y1 receptor (NPY1R) and their use in the treatment and/or diagnosis of cancer.

Abstract: Embodiments of the present disclosure relate to an electrostatic protection structure and an electrostatic protection circuit. The electrostatic protection structure includes: a SCR structure and a trigger structure; the SCR structure includes: a well region of a second conductivity type and a first well of a first conductivity type region, a first-doped region of the first conductivity type, and a first-doped region of the second conductivity type; the trigger structure includes: a first-doped region of the second conductivity type, a second well region of the first conductivity type, a second-doped region of two conductivity types, a third-doped region of the second conductivity type, a fourth-doped region of the second conductivity type, and a first gate electrode.

Abstract: The present disclosure provides a diode-triggered bidirectional silicon controlled rectifier and circuit. The silicon controlled rectifier includes: a P-type substrate; a first P well formed in the P-type substrate, a first P-type doped region and a first N-type doped region being formed in the first P well; a second P well formed in the P-type substrate, a third N-type doped region and a fourth P-type doped region being formed in the second P well; and an N well formed in the P-type substrate, a second P-type doped region, a second N-type doped region and a third P-type doped region being formed in the N well. The second N-type doped region is electrically connected with a positive electrode of a diode string, and the first P-type doped region and the fourth P-type doped region are electrically connected with a negative electrode of the diode string.

Abstract: Embodiments of the present disclosure relate to an electrostatic protection structure and an electrostatic protection circuit. The electrostatic protection structure includes: a SCR structure and a trigger structure; the SCR structure includes: a well region of a second conductivity type and a first well of a first conductivity type region, a first-doped region of the first conductivity type, and a first-doped region of the second conductivity type; the trigger structure includes: a first-doped region of the second conductivity type, a second well region of the first conductivity type, a second-doped region of two conductivity types, a third-doped region of the second conductivity type, a fourth-doped region of the second conductivity type, and a first gate electrode.

Abstract: The present disclosure provides antibody-drug conjugate structures, that include a cleavable linker having a sulfatase-cleavable moiety. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.

Abstract: The present invention relates to the field of fluid heat transfer, and discloses a heat transfer enhancement pipe as well as a cracking furnace and an atmospheric and vacuum heating furnace including the same. The heat transfer enhancement pipe (1) includes a pipe body (10) of tubular shape having an inlet (100) for entering of a fluid and an outlet (101) for said fluid to flow out; internal wall of the pipe body (10) is provided with a fin (11) protruding towards interior of the pipe body (10), the fin (11) spirally extends in an axial direction of the pipe body (10), wherein a height of the fin (11) gradually increases from one end in at least a part extension of the fin. The heat transfer enhancement pipe can reduce thermal stress of itself, thereby increasing service life of the heat transfer enhancement pipe.

Abstract: A discharge unit is connected to a power pad, a ground pad, and an I/O pad, and can discharge an electrostatic charge when an electrostatic pulse appears on any of the power pad, the ground pad, and the I/O pad. The discharge unit includes a first discharge unit and a second discharge unit, the first discharge unit is connected to the second discharge unit, the power pad, and the I/O pad, and the second discharge unit is connected to the ground pad and the I/O pad. The first discharge unit and/or the second discharge unit can discharge electrostatic charges on different pads, respectively.

Abstract: Most nitrogen recovery techniques recover acidic ammonium fertilizers, and few enable alkaline ammonia recovery. Many embodiments provide multi-chamber electrochemical stripping reactors to recover alkaline ammonia and acidic ammonium from wastewater. The reactor combines electrodialysis and membrane stripping. The acidic and alkaline product portfolio for wastewater-derived ammonia expand implementation opportunities for nitrogen recovery.