Abstract: A technology relating to a phototherapy device is disclosed. A therapeutic light source for outputting red light having a peak wavelength in the range of 660 nm±2% is driven by a driving pulse train having a constant pulse period during a pulse fluctuation period. The pulse period is randomly determined within a first range for each pulse fluctuation period. The optical radiant power density of a red wavelength band may be limited to be within the range of 20-100 mW/cm2-cm. A pause period of a random length in which the light source is turned off may be interposed between pulse fluctuation periods. In addition, the driving pulse train outputted during the pulse fluctuation period may have a randomly determined duty ratio.

Abstract: Provided is a composition for preventing or treating erectile dysfunction including angiopoietin-4 protein as an active ingredient. Angiopoietin-4 protein increases an endothelial cell-specific protein level to induce regeneration of penile vascular endothelial cells, thereby increasing intracavernous pressure. Thus, angiopoietin-4 protein may be efficiently applied to prevention or treatment of erectile dysfunction.

Abstract: A pharmaceutical composition for regenerating an endothelial cell which includes as an active ingredient a DKK2 protein or a polynucleotide encoding the DKK2 protein, a pharmaceutical composition for preventing or treating erectile dysfunction, a method of regenerating an endothelial cell of a subject and a method of preventing or treating erectile dysfunction of a subject and which treat or prevent erectile dysfunction in a subject.

Abstract: A pharmaceutical composition for regenerating an endothelial cell which includes as an active ingredient a DKK2 protein or a polynucleotide encoding the DKK2 protein, a pharmaceutical composition for preventing or treating erectile dysfunction, a method of regenerating an endothelial cell of a subject and a method of preventing or treating erectile dysfunction of a subject and which treat or prevent erectile dysfunction in a subject.

Abstract: Provided is a composition for preventing or treating erectile dysfunction including angiopoietin-4 protein as an active ingredient. Angiopoietin-4 protein increases an endothelial cell-specific protein level to induce regeneration of penile vascular endothelial cells, thereby increasing intracavernous pressure. Thus, angiopoietin-4 protein may be efficiently applied to prevention or treatment of erectile dysfunction.