Abstract: The present invention provides a diaryl compound as a tubulin/Src dual target inhibitor. The present invention also provides a diaryl compound represented by formula I, a tautomer, a stereoisomer, a solvate, a pharmaceutically acceptable salt, or a prodrug thereof. The diaryl compound can be used as a dual target inhibitor against tubulin and Src kinase and can also be used as a mono-target inhibitor against tubulin or Src kinase. The compound of the present invention can significantly inhibit the polymerization of tubulin monomers and cell proliferation.

Abstract: A method for prefabricating pore defects by controlling a SLM process, including performing laser scanning on a specified metal melt layer (LY) according to a first scan path (P1) and a second scan path. The first scan path (P1) and the second scan path (P2) have a path overlap zone (A0), the path overlap zone (A0) has a predetermined width, and laser energy input superimposed in the path overlap zone (A0) is controlled to reach a predetermined energy value, whereby keyholes are formed at a plurality of positions in a lengthwise direction of the path overlap zone (A0), the specified metal melt layer (LY) is taken as a defect layer, and the keyholes in the path overlap zone (A0) is taken as pore defects.

Abstract: The present application provides a method, a device, an apparatus, and storage medium for deviation correction of an electrode sheet. The deviation correction method of the electrode sheet includes: determining the first deviation amount of the electrode sheet on the stacking machine in the first direction; correcting a deviation of the electrode sheet in the first direction according to the first deviation amount; determining the second deviation amount of the electrode sheet in the second direction, wherein the second deviation amount is different from the first deviation amount; and correcting a deviation of the electrode sheet in the second direction according to the second deviation amount.

Abstract: Embodiments of the present disclosure provide a crystal growth device including: a crucible including a raw material cavity for placing a raw material and a growth cavity for crystal growth; and at least one insulation device disposed on at least one side surface outside the crucible.

Abstract: Disclosed are a solid-state laser and a solid-state laser system, including a laser emitting module, a reflection module, a refraction module, a coupling module and a transmission fiber arranged sequentially along a direction of an optical path. The laser emitting module includes at least four laser emitting units integrated in a same integrated chamber, and the laser beams emitted by each laser emitting unit are parallel and independent to each other. The reflection module includes a first reflection unit and a second reflection unit arranged sequentially along the direction of the optical path. The refraction module is coaxially arranged with the second reflection unit, and is configured to adjust the outgoing angle of the laser beams, and direct the laser beams adjusted by the refraction module to the coupling module. The coupling module is configured to couple at least four laser beams to enter the transmission fiber.

Abstract: Disclosed are a solid-state laser and a solid-state laser system, including a laser emitting module, a reflection module, a coupling module and a transmission fiber arranged sequentially along a direction of an optical path. The laser emitting module includes at least four laser emitting units integrated in a same integrated chamber, and the laser beams emitted by each laser emitting unit are parallel and independent to each other. The reflection module includes a first reflection unit and a second reflection unit arranged sequentially along the direction of the optical path. The coupling module and the second reflection unit are coaxially arranged and configured to adjust the emission angle of the laser beams, and couple at least four laser beams adjusted by the coupling module into the transmission fiber.

Abstract: A method for defect detection of a separator of a composite material strip includes obtaining a continuous image of the composite material strip; intercepting at least one image segment from the continuous image of the composite material strip, where the image segment includes a separator region; and performing detection on the separator region.

Abstract: A secure localization method for multi-mobile robots system based on network communication includes: Step 1, establishing a nonlinear dynamic model of a multi-mobile robots system based on network communication; Step 2, designing a secure estimator for the nonlinear dynamic model; Step 3, calculating an upper bound on a one-step prediction error covariance matrix ?i,k+1|k for each mobile robot in the network communication; Step 4, based on ?i,k+1|k, calculating an estimator gain matrix Ki,k+1 for each mobile robot in the network communication; Step 5, substituting the estimator gain matrix Ki,k+1 calculated in Step 4 into Step 2 to obtain a state estimation {circumflex over (x)}i,k+1|k+1 at time k+1; determining whether k+1 reaches a total duration M, that is, if k+1<M, performing Step 6, and if k+1=M, ending; and Step 6, based on Ki,k+1, calculating an upper bound on an estimation error covariance matrix ?i,k+1|k+1 of each mobile robot; let k=k+1, and performing Step 2 until k+1=M is satisfied.

Abstract: A counterfactual context-aware texture learning network system, including: a camera configured to capture an input image; a processor configured to perform camouflaged object detection on the input image; and a memory configured to store a texture-aware refinement module (TRM), a context-aware fused module (CFM), and a counterfactual intervention module (CIM); wherein the processor is configured to execute program instructions of the TRM, the CFM, and the CIM; the TRM is configured to extract dimension features from the input image; the CFM is configured to infuse multi-scale contextual features; the CIM is configured to identify a camouflaged object with counterfactual intervention via the processor; the TRM includes: a receptive field block (RFB) configured to expand a receptive field and extract texture features; and a position attention module (PAM) and a channel attention module (CAM) configured to further refine texture-aware features and obtain discriminant feature representation.

Abstract: A counterfactual context-aware texture learning network system, including: a camera configured to capture an input image; a processor configured to perform camouflaged object detection on the input image; and a memory configured to store a texture-aware refinement module (TRM), a context-aware fused module (CFM), and a counterfactual intervention module (CIM); wherein the processor is configured to execute program instructions of the TRM, the CFM, and the CIM; the TRM is configured to extract dimension features from the input image; the CFM is configured to infuse multi-scale contextual features; the CIM is configured to identify a camouflaged object with counterfactual intervention via the processor; the TRM includes: a receptive field block (RFB) configured to expand a receptive field and extract texture features; and a position attention module (PAM) and a channel attention module (CAM) configured to further refine texture-aware features and obtain discriminant feature representation.

Abstract: The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.

Abstract: Systems, apparatuses, and methods for prefetching data by a display controller. From time to time, a performance-state change of a memory are performed. During such changes, a memory clock frequency is changed for a memory subsystem storing frame buffer(s) used to drive pixels to a display device. During the performance-state change, memory accesses may be temporarily blocked. To sustain a desired quality of service for the display, a display controller is configured to prefetch data in advance of the performance-state change. In order to ensure the display controller has sufficient memory bandwidth to accomplish the prefetch, bandwidth reduction circuitry in clients of the system are configured to temporarily reduce memory bandwidth of corresponding clients.

Abstract: A display system modifies display cycles of one or more displays to perform a system operation while avoiding visual perturbations at the one or more displays. The display system modifies, synchronizes, or both, blanking periods of the one or more displays such that blanking periods equal or exceed a blackout duration and overlap for at least the blackout duration. Then the system performs the system operation during an overlapping portion of the one or more blanking periods, where the system operation reduces availability of display data at the one or more displays.

Abstract: Systems, apparatuses, and methods for prefetching data by a display controller. From time to time, a performance-state change of a memory are performed. During such changes, a memory clock frequency is changed for a memory subsystem storing frame buffer(s) used to drive pixels to a display device. During the performance-state change, memory accesses may be temporarily blocked. In order to reduce visual artifacts that may occur while the memory accesses are blocked, a memory subsystem includes a control circuit configured to enable a caching mode which caches display data provided to the display controller. Subsequent requests for display data from the display controller are then serviced using the cached data instead of accessing memory.

Abstract: Provided are an electromagnetic heating device, a noise suppression method, a heating control system, and a storage medium, which relate to the field of electromagnetic heating technologies. The noise suppression method includes: in response to determining that any two adjacent heating modules of the electromagnetic heating device operate successively, obtaining a start operating frequency of the last-started heating module of the two adjacent heating modules; and adjusting an operating frequency of the first-started heating module of the two adjacent heating modules based on the start operating frequency of the last-started heating module, to allow the two adjacent heating modules to operate synchronously at a same operating frequency when the last-started heating module starts operating.

Abstract: Provided is a cookware detection circuit using half-bridge drive heating, a heating device, a cookware detection method, and a storage medium. The cookware detection circuit using half-bridge drive heating includes a control module (100) and a pulse cookware detection module (300). The control module is configured to output a single pulse cookware detection signal to a half-bridge drive module (200) of the electromagnetic heating device to drive a coil disk (204) to perform a resonant operation through the half-bridge drive module (200). A pulse detection module (300) is connected to the coil disk (204) and configured to detect a resonant current of the coil disk (204) and generate pulse signals based on the resonant current of the coil disk (204). The control module (100) is connected to the pulse detection module (300), and is further configured to count the pulse signals and determine whether cookware is placed on the electromagnetic heating device based on the number of the pulse signals.

Abstract: An electromagnetically heated cooking utensil, and a heating control circuit and method therefor. The heating control circuit includes a first resonance device; a second resonance device; a first power switch; a second power switch; a first synchronization device that detects voltages of both ends of the first resonance device to output a first synchronization signal; a second synchronization device that detects voltages of both ends of the second resonance device to output a second synchronization signal; and a control device that selects, according to the heating mode of the electromagnetically heated cooking utensil, the first synchronization signal to generate a driving signal for driving the first power switch, a second synchronization signal to generate a driving signal for driving the second power switch.

Abstract: Described is a conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. Also described are a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.

Abstract: Described is a conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. Also described are a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.