Abstract: The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-5N-(methyl-d3)pyridazine-3-carboxamide of the formula: Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.

Abstract: The invention pertains to methods and vaccines suitable for preventing or reducing malaria transmission. The vaccines block the interaction between ?-tubulin from a malarial parasite and FREP-1 from the mid-gut of a malaria carrier mosquito, for example, Anopheles gambiae.

Abstract: This application relates to the field of communications technologies, and provides a data transmission method and a communications apparatus, to reduce complexity and overheads of data reception performed by a base station. The method includes: receiving information about a repetition quantity R1 corresponding to Tmax, where Tmax is a maximum transport block size allowed to be used to transmit data; determining a cyclic parameter L based on R1, where the cyclic parameter L indicates that content carried in each of a plurality of time units to which a transport block used to transmit the data is mapped is repeated in L consecutive time units, and wherein a size of the transport block used to transmit the data is Ts, and Ts<Tmax; and transmitting the data based on the cyclic parameter L.

Abstract: Embodiments of the present invention synchronize multiple synthesizers, such as phase-locked loops (PLLs), in a manner that does not require communication or coordination between the synthesizers. Specifically, each synthesizer is part of a synthesizer circuit that includes a synthesizer (e.g., a PLL), a phase measurement circuit, and a synchronization circuit. A common reference signal (e.g., an alternating clock signal) is provided to the synthesizer circuits. In one exemplary embodiment, in each synthesizer circuit, the phase measurement circuit measures a phase difference between the reference signal and a corresponding output of the synthesizer, and the synchronization circuit adjusts the synthesizer operation based on the measured phase difference in such a way that all of the synthesizers operate in-phase with one another relative to the common reference signal, without having any communication or coordination between the two synthesizer circuits other than provision of the common reference signal.

Abstract: Techniques for implementing and/or operating an electronic device including a display pixel layer, which writes a display image during an active period and continues displaying the display image during a blanking period, and a touch sense layer, which generates a first touch image during the active period and a second touch image during the blanking period. The electronic device further includes a controller that determines a first noise metric indicative of display-to-touch noise resulting during the active period based on the first touch image, determines a second noise metric indicative of display-to-touch noise resulting during the blanking period based on the second touch image, and instructs the touch sense layer to not generate a third touch image during a subsequent active period in response to the first noise metric being greater than a noise threshold and the second noise metric not being greater than the noise threshold.

Abstract: A vehicle-mounted TBOX, an antenna real-time switching method and apparatus, and a non-transitory computer-readable storage medium are disclosed. The vehicle-mounted TBOX may include: a MCU control device, an antenna device and a measurement device, where the measurement device is configured to detect an incident wave power and a reflected wave power when the antenna device is in operation, and determine a real-time standing wave ratio at a position where the antenna device locates; the MCU control device is configured to communicate with the antenna device and the measurement device, determine an operation state of the antenna device according to the standing wave ratio, and send a control instruction to the antenna device; and the antenna device is configured to switch an internal antenna of the antenna device in real time according to the control instruction.

Abstract: A single mode optical fiber is provided that includes a core region having an outer radius r1 and a maximum relative refractive index ?1max. The single mode optical fiber further includes a cladding region surrounding the core region, the cladding region includes a depressed-index cladding region, a relative refractive index ?3 of the depressed-index cladding region increasing with increased radial position. The single mode optical fiber has a bend loss at 1550 nm for a 15 mm diameter mandrel of less than about 0.75 dB/turn, a bend loss at 1550 nm for a 20 mm diameter mandrel of less than about 0.2 dB/turn, and a bend loss at 1550 nm for a 30 mm diameter mandrel of less than 0.005 dB/turn. Additionally, the single mode optical fiber has a mode field diameter of 9.0 microns or greater at 1310 nm wavelength.

Abstract: A coupled-core multicore optical fiber has a plurality of cores that are doped with alkali metals or chlorine to achieve low attenuation and a large effective area. The cores may be embedded in a common cladding region that may be fluorine doped. The cores may also be doped with chlorine, either with the alkali metals described above or without the alkali metals.

Abstract: A pixel circuit and a display panel are provided. The display includes the pixel circuit. The pixel circuit includes a data line, a scan line, a plurality of hierarchical 2T1C circuits, a step-down circuit, and a reset circuit. The data line is configured to transmit a source data signal. The scan line is configured to transmit a scan signal. Each input of the plurality of hierarchical 2T1C circuits is connected to the scan line in parallel. An input of the step-down circuit is connected to the data line and an output of the step-down circuit is connected to another input of each 2T1C circuit. The reset circuit is connected to the input of the step-down circuit.

Abstract: A test device for testing and commissioning comprehensive performance of a rotary drilling rig is provided. Dynamometer motors in the test device are provided on a foundation. A torque transmission gearbox is fixed on a gearbox anchoring plate through a gearbox adapter plate. A speed-increasing corner gearbox is provided on the torque transmission gearbox and connected to the dynamometer motors through a transmission shaft, a torque sensor, and a motor coupling sequentially. A drive sleeve is provided in a connecting shaft of the torque transmission gearbox. A lower end of the drive sleeve is connected to a hydraulic loading cylinder through a rotating bearing, a rotating support, and a tension-pressure sensor. The rotating support is fixed in the foundation. The hydraulic loading cylinder is connected to a hydraulic station through a hydraulic pipe. The tension-pressure sensor and a pressure control valve are connected to a computer software control system.

Abstract: Apparatus, systems, computer-readable storage media, and methods for computer-based games and matches are disclosed. An example computer system for managing a prize that can be awarded based on an outcome of a game includes a data processing arrangement. The example data processing arrangement is arranged to: access historical game data, wherein the historical game data represents information about historical outcomes of the game; process the historical game data to generate probability data, wherein the probability data represents information about a plurality of discrete probabilities each of which is associated with a different future outcome of the game; and process the probability data to generate prize data, wherein the prize data represents at least one characteristic associated with the prize.

Abstract: A preset three-stage adjustable downhole choke with choking and pressure measurement functions includes an intake assembly for natural gas filtration, an electrically-controlled telescopic assembly for positioning and clamping the downhole choke with a prefabricated seating nipple, and a three-stage choking assembly for natural gas choking and depressurization. The intake assembly, the electrically-controlled telescopic assembly, and the three-stage choking assembly are sequentially communicated from bottom to top. A first-stage control choke, a second-stage adjustable control choke, and a third-stage control choke are sequentially provided in a gas passage of the three-stage choking assembly from bottom to top. The preset three-stage adjustable downhole choke features convenient installation and removal, three-stage choking and depressurization, and an adjustable orifice diameter of a control choke, and can achieve different choking and depressurization effects.

Abstract: A reservoir device includes: a liquid storage structure, configured to store liquid; a liquid feeding assembly, configured to feed the liquid into the liquid storage structure; a barrier assembly; a sensing field generator, configured to generate a sensing field; a sensor; and an electrical control assembly. The barrier assembly is arranged inside the liquid storage structure. The sensor is configured to sense the sensing field. The barrier assembly is configured to float under a buoyance action of the liquid, and to block the sensor from sensing the sensing field when the barrier assembly floats in a first liquid level position. The electrical control assembly is configured to control the liquid feeding assembly to stop feeding the liquid into the liquid storage structure when the barrier assembly blocks the sensor from sensing the sensing field.

Abstract: In a data processing method, a processing device performs encoding, based on spatial position data and time position data of a trajectory point of a trajectory according to an encoding rule of a hybrid code of a preset level in an index database, to obtain a hybrid code of each trajectory point. The hybrid code includes temporal information and spatial position information of the trajectory point. The processing device then queries a similar trajectory in the index database based on the hybrid code of each trajectory point. The index database includes hybrid codes of a plurality of levels, and the index database includes hybrid codes with trajectory information that includes a trajectory identifier and a trajectory length.

Abstract: The present disclosure relates to a thin coated optical fiber that enables connector assembly without stripping the optical fiber. In particular, the thin coating comprises a hard coating, a dye concentrate, and an adhesion promoter. The formulation of the coating promotes adhesion to a glass cladding of the optical fiber and to a ferrule bore (into which the optical fiber is inserted) by not causing silane decomposition of the coating. Moreover, the coating is colored to enable, among other things, fiber identification within a connector. The thin coated optical fibers exhibit good mechanical and optical performance properties as discussed herein.

Abstract: The present invention relates to the technical field of medicines. Specifically disclosed is a compound as represented by formula I?, or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof, symbols therein being as defined in the claims. The compound of the present invention may be used as a drug for regulating RET kinase activity or treating RET-related diseases, and has good pharmacokinetic properties.

Abstract: A household appliance, a control panel assembly and a touch module thereof are provided. The control panel assembly of the household appliance includes a touch panel and a touch module. The touch module includes a touch sensor group and a structural support frame. The touch sensor group includes one or more touch sensors. One side of the touch sensor is adhered to the structural support frame, and the touch module abuts against the touch panel, so that the other side of the touch sensor is attached to the touch panel. This provides a novel control panel assembly of a household appliance.

Abstract: The present invention provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities.

Abstract: The present invention provides a method of preparing an MOF-coated monocrystal ternary positive electrode material. Firstly, a solution A of nickel, cobalt and manganese metal salts, an ammonia complexing agent solution and a caustic soda liquid are added to a reactor for reaction to obtain a precursor core; then, an organic carboxylate is dissolved in an amount of an organic solvent to obtain a solution B; the solution B and a manganese metal salt solution with a given concentration are added to the reactor and aged to obtain an MOF-coated core-shell structure precursor; the core-shell structure precursor is pre-sintered at a low temperature to obtain a nickel-cobalt-manganese oxide with monocrystal structure; the nickel-cobalt-manganese oxide with monocrystal structure is uniformly mixed with LiOH·H2O in a mortar and then calcined at a high temperature to obtain an MOF-coated monocrystal ternary positive electrode material.

Abstract: Embodiments of this application provide a rendering method and apparatus, and the like. The method includes: A processor (which is usually a CPU) modifies a rendering instruction based on a relationship between a first frame buffer and a second frame buffer, so that a GPU renders a rendering job corresponding to the first frame buffer to the second frame buffer based on a new rendering instruction. In this application, render passes of one or more frame buffers are redirected to another frame buffer. In this way, memory occupation in a rendering process of an application program is effectively reduced, bandwidth of the GPU is reduced, and power consumption can be reduced.