Abstract: Disclosed are a polypeptide ester ether amine random polymer and a preparation method and application thereof. The polypeptide ester ether amine random polymer is a random copolymer of an amino acid monomer and an epoxyalkane. In the present invention, copolymerization of the amino acid monomer and the epoxyalkane monomer is achieved by a one-step monomer mixing method using a transition metal or rare earth metal salt as a catalyst. The random copolymerization product has a controllable molecular weight, a narrow molecular weight distribution, and adjustable copolymer composition. Moreover, the random copolymerization product has good solubility, biodegradability, easy functionalization and modification, good processability and good biocompatibility, and has a broad application prospect in the biomedical field.

Abstract: Provided are a transaminase mutant and use thereof. The transaminase mutant is obtained by mutation occurred in an amino acid sequence as shown in SEQ ID NO:1, and the mutation includes at least T291A; or an amino acid sequence of the transaminase mutant has the mutation in the mutated amino acid sequence, and has more than 80% of identity with the mutated amino acid sequence, preferably has 85% of identity, and more preferably has 90% of identity.

Abstract: A test device includes a housing and a carrier detachable from the housing. The housing includes a socket, and the carrier contains a testing element, and the carrier along with the testing element therein is capable of being inserted into the housing through the socket. The housing includes a blocking structure and a locking structure. The blocking structure and the locking structure are integrated to form a locking component. When the carrier is inserted into the housing, and a position of the carrier is locked by the locking structure, the carrier is abutted against the blocking structure. The carrier keeps stable after being inserted into the housing; and the carrier is located in the same position for each insertion.

Abstract: A test device includes a housing and a carrier detachable from the housing. The housing includes a socket, and the carrier contains a testing element, and the carrier along with the testing element therein is capable of being inserted into the housing through the socket. The housing includes a blocking structure and a locking structure. The blocking structure and the locking structure are integrated to form a locking component. When the carrier is inserted into the housing, and a position of the carrier is locked by the locking structure, the carrier is abutted against the blocking structure. The carrier keeps stable after being inserted into the housing; and the carrier is located in the same position for each insertion.

Abstract: The disclosure discloses an amphiphilic polymer nano micelle containing poly-3,4-dihydroxyphenylalanine chelated ferric ions, in which ferric ions are chelated with a catechol structure on a side chain of a biodegradable poly-3,4-dihydroxyphenylalanine block. The disclosure also provides a method for preparing the above micelle, comprising: complexing an amphiphilic polymer containing poly-3,4-dihydroxyphenylalanine with a ferric ion compound, and obtaining the amphiphilic polymer nano micelle containing poly-3,4-dihydroxyphenylalanine chelated ferric ions through a solvent replacement method. The micelle prepared by the disclosure is used as a Fe3+ magnetic resonance Ti imaging contrast agent, which can avoid toxic or side effects caused by a traditional gadolinium reagent, has a longitudinal relaxation rate of 5.

Abstract: The disclosure provides methods and compositions useful for treating claudin-4 associated disorders including cell proliferative disorders. The disclosure also provide claudin-family binding peptides useful in the methods of the disclosure.

Abstract: The disclosure provides methods and compositions useful for treating claudin-4 associated disorders including cell proliferative disorders. The disclosure also provide claudin-family binding peptides useful in the methods of the disclosure.