Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts and esters thereof: which inhibit the Apoptosis signal-regulating kinase 1 (ASK-1), which is associated with autoimmune disorders, neurodegenerative disorders, inflammatory diseases, chronic kidney disease, cardiovascular disease. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from ASK-1 related disease. The invention also relates to methods of treating an ASK-1 related disease in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention specifically relates to methods of treating ASK-1 associated with hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).

Abstract: The invention provides a positioning tool and a busbar mounting method. The positioning tool includes a first mount, a second mount, a first link, a second link and a positioning base. The first mount and the second mount are configured to be mounted on opposite sides of the server cabinet, respectively. The first link and the second link are spaced apart from each other. Opposite ends of the first link are respectively pivotally connected to the first mount and the second mount. Opposite ends of the second link are respectively pivotally connected to the first mount and the second mount. The positioning base is pivotally connected to the first link and the second link. The positioning base is located between the first mount and the second mount and is configured to position the busbar.

Abstract: A supported metallocene catalyst includes a carrier and a metallocene component. The carrier includes an inorganic oxide particle and an alkyl aluminoxane material. The inorganic oxide particle includes at least one inorganic oxide compound selected from the group consisting of an oxide of Group 3A and an oxide of Group 4A. The alkyl aluminoxane material includes an alkyl aluminoxane compound and an alkyl aluminum compound that is present in amount ranging from greater than 0.01 wt % to less than 14 wt % base on 100 wt % of the alkyl aluminoxane material. The metallocene component is supported on the carrier, and includes one of a metallocene compound containing a metal from Group 3B, a metallocene compound containing a metal from Group 4B, and a combination thereof. A method for preparing the supported metallocene catalyst and a method for preparing polyolefin using the supported metallocene catalyst are also disclosed.

Abstract: Aspects include determining a coding intention and a dimension of interest to a user. A plurality of relevant projects that each include a logical code block that meets the coding intention are located. The locating includes searching a plurality of code repositories based at least in part on the coding intention. A score is assigned to each of the plurality of logical code blocks based at least in part on properties associated with the logical code blocks and on the dimension of interest to the user. A logical code block with the highest score is promoted to the user.

Abstract: The present invention discloses a fragrance machine, comprising: a driving component and an atomizing component are mounted in a housing; the driving component comprises an air pump and a power supply which are arranged in the housing; the air pump is mounted in a cavity jointly defined by a cover body and a mounting seat; the atomizing component comprises an atomizing pipe, an atomizing nozzle, a connecting pipe and a liquid storage bottle. The present application has a good atomization effect, and the noise generated by the air pump during operation can be effectively blocked, so that the noise during operation of the fragrance machine is very low.

Abstract: Implementations of the present disclosure relate to security testing based on user request. According to the method, a first request for a target application is received from a first user. A first malicious request is generated by modifying the first request, wherein the first malicious is associated with a malicious action on the target application. The first malicious request is sent to an offline instance of the target application. A first security level of the target application against the malicious action is determined based on a first response generated by the offline instance in response to the first malicious request. In other implementations, a system and a computer program product for process tracking are disclosed.

Abstract: A method, system, and computer program product for dependency-based software upgrading. The method may include determining respective dependency degrees between a plurality of software products based on property information related to a plurality of upgraded versions of the plurality of software products, a target software product depending on the plurality of software products. The method may also include dividing the plurality of software products into a plurality of groups of software products based on the respective dependency degrees. The method may also include determining a plurality of test scores associated with the plurality of groups, each test score indicating a performance enhancement degree of the target software product achieved by installing upgraded versions of at least one software product comprised in one of the plurality of groups. The method may also include determining a target upgrade solution for the target software product based on the plurality of test scores.

Abstract: The present disclosure provides glass, and a manufacturing method and a control method thereof. The glass includes a first glass layer, a plurality of transparent conductive strips and a second glass layer. The plurality of transparent conductive strips are between the first glass layer and the second glass layer, and are configured to generate heat when being supplied with power.

Abstract: The present disclosure relates to at least one method for ascertaining at least one attribute of pressure vessel wall. A method comprises: while a pressure vessel, which comprises a wall having an outer surface and an inner surface, is operating: ascertaining a current wavelength shift of a first fiber Bragg grating (FBG) sensor disposed at a first outer surface location on the pressure vessel; and ascertaining a current thickness of the wall at the first outer surface location by: computing a vector based on a time series of the current wavelength shift, or a derivative of the time series, or a derivative of the current wavelength shift; providing the vector to a predetermined regression model; and using the regression model, ascertaining the current thickness of the wall.

Abstract: A mist removing device, a controlling method thereof a mist removing system and a control element are provided, which relate to the field of mist removing technology. The mist removing device includes power supply module, electrode array and insulating layer. Electrode array and insulating layer are arranged on substrate in stacked manner in direction away from substrate. Orthographic projection of insulating layer onto substrate covers orthographic projection of electrode array onto substrate. Power supply module is connected with electrode array. Power supply module is configured to supply power to electrode array such that electrode array forms electric field to cause droplets in mist to converge under action of electric field, where mist is formed on side of insulating layer away from substrate. Mist on surface of substrate can be effectively removed.

Abstract: Aspects include determining a coding intention and a dimension of interest to a user. A plurality of relevant projects that each include a logical code block that meets the coding intention are located. The locating includes searching a plurality of code repositories based at least in part on the coding intention. A score is assigned to each of the plurality of logical code blocks based at least in part on properties associated with the logical code blocks and on the dimension of interest to the user. A logical code block with the highest score is promoted to the user.

Abstract: A desulfurization catalyst includes at least: 1) a sulfur-storing metal oxide, 2) an inorganic binder, 3) a wear-resistant component, and 4) an active metal component. The sulfur-storing metal is one or more of a metal of Group IIB of the periodic table, a metal of Group VB of the periodic table, and a metal of Group VIB of the periodic table, e.g., zinc. The desulfurization catalyst has a good stability and a high desulfurization activity.

Abstract: A method for controlling the solids distribution in a bitumen froth produced when processing an oil sands ore having a d50 of about 250 ?m or greater and a d90 of about 450 ?m or greater is provided comprising adding a high-fines material having a d50 of about 50 ?m or less and a fines content of about 40% of the solids or greater to the oil sands ore to form an ore blend; and processing the ore blend in a water-based bitumen extraction process to produce the bitumen froth.

Abstract: A process for producing light olefins from inferior oils includes the steps of: subjecting an inferior oil to a thermal conversion reaction in the presence of hydrogen to obtain a conversion product; separating the conversion product to obtain a first separated product; separating the first separated product to obtain an upgraded oil and a pitch; subjecting the upgraded oil to hydro-upgrading to obtain a hydro-upgraded oil; separating the hydro-upgraded oil to obtain a hydro-upgraded heavy oil; and subjecting the hydro-upgraded heavy oil to catalytic cracking to obtain a catalytic cracking product comprising a light olefin.

Abstract: A method for extracting bitumen from an oil sands ore comprising swelling clays such as smectite is provided comprising blending said ore sands ore comprising swelling clays with a substantially swelling clays-free oil sands ore to give a blended oil sands ore having less than 1% swelling clays.

Abstract: A method for extracting bitumen from an oil sands ore comprising swelling clays such as smectite is provided comprising blending said ore sands ore comprising swelling clays with a substantially swelling clays-free oil sands ore to give a blended oil sands ore having less than 1% swelling clays.

Abstract: Disclosed is a process and system for upgrading low-quality oils. The upgrading process comprises: (1) subjecting a low-quality oil to a conversion reaction in the presence of hydrogen and optionally in the presence of a conversion catalyst to obtain a conversion product, (2) processing the conversion product to obtain a first processed product, wherein the first processed product comprises a specific amount of a special component, and (3) subjecting the first processed product to extraction separation to obtain an upgraded oil and a pitch. The upgrading process and the upgrading system have the advantages of stable operation, high upgrading efficiency, environmental friendliness, low coke yield or high yield of upgraded oil.

Abstract: A process for producing catalytic cracking gasoline includes the following steps: i) subjecting a heavy feedstock oil to a catalytic cracking reaction in the presence of a first catalytic cracking catalyst to obtain a first reaction product; ii) subjecting a hydrogenated cycle oil to a catalytic cracking reaction in the presence of a second catalytic cracking catalyst to obtain a second reaction product; iii) separating a mixture of the first reaction product and the second reaction product to obtain a catalytic cracking gasoline and a catalytic cracking light cycle oil; iv) subjecting the catalytic cracking light cycle oil or a fraction thereof to hydrogenation to obtain a hydrogenated product; and v) recycling the hydrogenated product to the step ii) as the hydrogenated cycle oil.

Abstract: A method for hosting a poker game for a plurality of players includes: when an all-in bet among at least two players has occurred, and when a predetermined insurance condition is met, providing the leading player with an option to purchase an insurance with respect to the at least one out; when the at least one out is dealt as a turn card and the leading player has purchased the insurance covering the out, paying the leading player a payout; and when it is determined that the leading player has purchased the insurance, and the at least one out is not dealt at the turn stage, a user-designated insurance premium is collected from the leading player.

Abstract: Implementations of the present disclosure relate to security testing based on user request. According to the method, a first request for a target application is received from a first user. A first malicious request is generated by modifying the first request, wherein the first malicious is associated with a malicious action on the target application. The first malicious request is sent to an offline instance of the target application. A first security level of the target application against the malicious action is determined based on a first response generated by the offline instance in response to the first malicious request. In other implementations, a system and a computer program product for process tracking are disclosed.