Patents by Inventor Jun-Ming Cai

Jun-Ming Cai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Motif-specific and context-independent antibodies that specifically bind to a sumoylated lysine-containing residue
    Patent number: 12577295
    Abstract: There is provided a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) at least one sumoylated lysine residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said sumoylated lysine residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs. Also provided is a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) a C-terminal aspartic acid residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said C-terminal aspartic acid residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs.
    Type: Grant
    Filed: June 30, 2022
    Date of Patent: March 17, 2026
    Assignee: Cell Signaling Technology, Inc.
    Inventors: Michael Comb, Ailan Guo, John Edward Rush, II, Jun-Ming Cai, Jing Li, Jing Zhou
  • MOTIF-SPECIFIC AND CONTEXT-INDEPENDENT ANTIBODIES THAT SPECIFICALLY BIND TO A SUMOYLATED LYSINE-CONTAINING RESIDUE
    Publication number: 20230033264
    Abstract: There is provided a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) at least one sumoylated lysine residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said sumoylated lysine residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs. Also provided is a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) a C-terminal aspartic acid residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said C-terminal aspartic acid residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs.
    Type: Application
    Filed: June 30, 2022
    Publication date: February 2, 2023
    Applicant: CELL SIGNALING TECHNOLOGY, INC.
    Inventors: Michael COMB, Ailan GUO, John Edward RUSH, II, Jun-Ming CAI, Jing LI, Jing ZHOU
  • Motif-specific and context-independent antibodies that specifically bind to a sumoylated lysine-containing residue
    Patent number: 11377486
    Abstract: There is provided a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) at least one sumoylated lysine residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said sumoylated lysine residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs. Also provided is a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) a C-terminal aspartic acid residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said C-terminal aspartic acid residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: July 5, 2022
    Assignee: CELL SIGNALING TECHNOLOGY, INC.
    Inventors: Michael Comb, Ailan Guo, John Edward Rush, II, Jun-Ming Cai, Jing Li, Jing Zhou
  • Motif-Specific and Context-Independent Antibodies That Specifically Bind to a Sumoylated Lysine-Containing Residue
    Publication number: 20200317760
    Abstract: There is provided a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) at least one sumoylated lysine residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said sumoylated lysine residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs. Also provided is a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) a C-terminal aspartic acid residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said C-terminal aspartic acid residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs.
    Type: Application
    Filed: August 9, 2019
    Publication date: October 8, 2020
    Inventors: Michael Comb, Ailan Guo, John Edward Rush, II, Jun-Ming Cai, Jing Li, Jing Zhou
  • Compositions and methods for detecting EGFR in cancer
    Patent number: 10000568
    Abstract: The invention discloses binding agents to the E746-A750 deletion and the L858R point mutations in the epidermal growth factor receptor (EGFR) molecule, and methods for use thereof, including methods for the diagnosis and treatment of cancer.
    Type: Grant
    Filed: April 10, 2009
    Date of Patent: June 19, 2018
    Assignee: Cell Signaling Technology, Inc.
    Inventors: Ting-Lei Gu, Jiong Wu, Susan Kane, Jian Yu, Herbert Haack, James Wieler, Jun-Ming Cai, Victoria Rimkunas
  • Motif-Specific and Context-Independent Antibodies That Specifically Bind to a Cleaved Caspase Motif
    Publication number: 20160319001
    Abstract: There is provided a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) at least one sumoylated lysine residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said sumoylated lysine residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs. Also provided is a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) a C-terminal aspartic acid residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said C-terminal aspartic acid residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs.
    Type: Application
    Filed: February 1, 2016
    Publication date: November 3, 2016
    Inventors: Michael Comb, Ailan Guo, John Edward Rush, II, Jun-Ming Cai, Jing Li, Jing Zhou
  • Motif-specific and context-independent antibodies that specifically bind to a cleaved caspase motif
    Patent number: 9249231
    Abstract: There is provided a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) at least one sumoylated lysine residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said sumoylated lysine residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs. Also provided is a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) a C-terminal aspartic acid residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said C-terminal aspartic acid residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs.
    Type: Grant
    Filed: November 4, 2011
    Date of Patent: February 2, 2016
    Assignee: Cell Signaling Technology, Inc.
    Inventors: Michael Comb, Ailan Guo, John Edward Rush, II, Jun-Ming Cai, Jing Li, Jing Zhou
  • Motif-Specific and Context-Independent Antibodies That Specifically Bind to a Cleaved Caspase Motif or a Sumoylated Lysine-Containing Motif
    Publication number: 20120208985
    Abstract: There is provided a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) at least one sumoylated lysine residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said sumoylated lysine residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs. Also provided is a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) a C-terminal aspartic acid residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said C-terminal aspartic acid residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs.
    Type: Application
    Filed: November 4, 2011
    Publication date: August 16, 2012
    Applicant: CELL SIGNALING TECHNOLOGY, INC.
    Inventors: Michael Comb, Ailan Guo, John Edward Rush, II, Jun-Ming Cai, Jing Li, Jing Zhou
  • COMPOSITIONS AND METHODS FOR DETECTING EGFR IN CANCER
    Publication number: 20120093837
    Abstract: The invention discloses binding agents to the E746-A750 deletion and the L858R point mutations in the epidermal growth factor receptor (EGFR) molecule, and methods for use thereof, including methods for the diagnosis and treatment of cancer.
    Type: Application
    Filed: April 10, 2009
    Publication date: April 19, 2012
    Inventors: Ting-Lei Gu, Jiong Wu, Susan Kane, Jian Yu, Herbert Haack, James Wieler, Jun-Ming Cai, Victoria Rimkunas