Abstract: The use of ionic liquids as a solvent for chemoselective bioconjugation reactions is described. For example, methods of preparing bioconjugates in ionic liquids via a phosphine-mediated azide-amine reaction to form a urea linkage between a biomolecule substrate and a second molecule are described. Methods of preparing bioconjugates with amide or enamine linkages in ionic liquids are also described. The methods can be used to prepare tagged biomolecules, such as dye-tagged proteins, peptides, nucleic acids, or saccharides (e.g., aminosaccharides), for use in various applications; to form biomolecule-polymer conjugates; or to form biomolecule-therapeutic agent conjugates, such as antibody-drug conjugates.

Abstract: A memory device sharing system includes M (M represents an integer of 2 or greater) access control apparatus for sharing N (N represents an integer of 2 or greater) memory devices which store data, and a managing apparatus for managing access to the memory devices via the access control apparatus. The managing apparatus checks data stored in the N memory devices, generates data position information representative of the storage positions of data stored in any one of the N memory devices, and sends the data position information to the M access control apparatus. Each of the M access control apparatuses receives the data position information sent from the manager, and accesses the storage position indicated by the data position information if each of the M access control apparatuses receives an access request to access the data from an access request source.