Abstract: An ophthalmic photography apparatus is provided with an irradiation optical system that irradiates a subject's eye with near-infrared light containing two or more wavelength components, a light receiving optical system that forms an image by concentrating reflected light derived from the near-infrared light reflected off a fundus or interior of the subject's eye, an imaging unit that outputs an image signal for each wavelength component by taking a fundus image or an intraocular image formed by the light receiving optical system, and an image generation unit that generates a fundus image or an intraocular image of the subject's eye by combining image signals outputted from the imaging unit.

Abstract: There are provided a detector and a detection method capable of detecting a biological sample with high sensitivity. A detector is provided with a microchamber array including a plurality of storage sections to be filled with a hydrophilic solvent containing a biological sample; and an image sensor in which picture elements are disposed corresponding to the storage sections, wherein the microchamber array includes a flow channel in communication with openings of the storage sections; a hydrophobic solvent supply unit arranged in continuity with the flow channel; and a through-hole which allows the hydrophilic solvent to enter and exit the flow channel, and the hydrophobic solvent supply unit flows a hydrophobic solvent into the flow channel by an externally-applied force.

Abstract: Providing an electrode structure capable of realizing an electrode array which allows each of the electrodes to be individually controlled while allowing them to be densely arranged and placed in a living body. According to the present invention, an electrode control circuit electrically connected to an electrode body is fixed to a rear portion of the electrode body within a front-viewed contour of the electrode body. This electrode control circuit may be contained in a recess formed in the rear portion of the electrode body, or it may be fixed to the back face of the electrode body. Conversely, an electrically conductive material layer covering the electrode control circuit may be used as the electrode body. A plurality of such bioelectrodes may be arranged in a two-dimensional form on a substrate or connected by a connection line including an electrical wire. Such configurations allow the bioelectrodes to be densely arranged.

Abstract: Providing an electrode structure capable of realizing an electrode array which allows each of the electrodes to be individually controlled while allowing them to be densely arranged and placed in a living body. According to the present invention, an electrode control circuit electrically connected to an electrode body is fixed to a rear portion of the electrode body within a front-viewed contour of the electrode body. This electrode control circuit may be contained in a recess formed in the rear portion of the electrode body, or it may be fixed to the back face of the electrode body. Conversely, an electrically conductive material layer covering the electrode control circuit may be used as the electrode body. A plurality of such bioelectrodes may be arranged in a two-dimensional form on a substrate or connected by a connection line including an electrical wire. Such configurations allow the bioelectrodes to be densely arranged.

Abstract: There are provided a detector and a detection method capable of detecting a biological sample with high sensitivity. A detector is provided with a microchamber array including a plurality of storage sections to be filled with a hydrophilic solvent containing a biological sample; and an image sensor in which picture elements are disposed corresponding to the storage sections, wherein the microchamber array includes a flow channel in communication with openings of the storage sections; a hydrophobic solvent supply unit arranged in continuity with the flow channel; and a through-hole which allows the hydrophilic solvent to enter and exit the flow channel, and the hydrophobic solvent supply unit flows a hydrophobic solvent into the flow channel by an externally-applied force.

Abstract: An intracerebral information measuring device which can be mounted on the head of a subject by simple surgery and which attains measurement of low invasion, high sensitivity, and high resolution is provided. An internally mounted unit is composed of a probe section to be inserted in the brain through a hole having a small diameter bored in the skull of the subject, and a head section integrated with the probe section and to be disposed between the skull and the scalp. The probe section includes an electrode for sensing an action potential. The head section includes a transmitter for wirelessly transmitting signals captured with the electrode to the outside. On the outside of the head, an external measuring unit for receiving the signal transmitted from the head section and reproducing the original signal is provided.

Abstract: An intracerebral information measuring device which can be mounted on the head of a subject by simple surgery and which attains measurement of low invasion, high sensitivity, and high resolution is provided. An internally mounted unit is composed of a probe to be inserted in the brain through a hole having a small diameter bored in the skull of the subject, and a head section integrated with the probe section and to be disposed between the skull and the scalp. The probe section includes an electrode for sensing an action potential. The head section includes a transmitter for wirelessly transmitting signals captured with the electrode to the outside. On the outside of the head, an external measuring unit for receiving the signal transmitted from the head section and reproducing the original signal is provided.

Abstract: The uppermost metallic wiring layer in light-blocking layers constituted by multilevel metallic wiring that prevents light from impinging on areas other than the light-receiving area of a photodiode in each picture cell is used as a measurement electrode to be directly contacted with a specimen to measure electrical signals. Furthermore, in each picture cell including a circuit for reading out electrical signals collected through the measurement electrode, another circuit for reading out electrical signals generated by the photodiode is provided in an independent or shared form. This configuration enables the photodiode for optical measurements and the measurement electrode for electrical measurements to be provided in every picture cell.

Abstract: After resetting the potential VPD of the photodiode (11) to the predetermined potential VRST, light is incident onto the photodiode (11) for a predetermined period to decrease the VPD corresponding to the amount of the incident light. After that, a declivous ramp voltage VRAMP is applied to the source terminal of the first MOS transistor (12) which is a common-source amplifier for reading out the VPD. When the voltage difference between the gate and source of the MOS transistor (12) exceeds a threshold voltage, the MOS transistor is turned on and the output suddenly decreases. If a signal having a pulse width from the starting point of the sweep of the ramp voltage to the sudden lowering point of the output is generated, the pulse width depends on the amount of the incident light. With the signal readout of this PWM method, it is possible to lower the power consumption while a wide dynamic range is maintained, and to downsize the picture cells to achieve a higher number of picture cells.

Abstract: A pixel includes a photodiode, an overflow circuit, a first sensing circuit, and a second sensing circuit. The first sensing circuit charges and discharges a cathode capacitance by a photocurrent flowing through a photodiode, and amplifies an obtained voltage by a source follower amplifier so as to be outputted to a data line. The second sensing circuit charges and discharged the cathode capacitance by the photocurrent flowing through the photodiode, and outputs electric charge stored in the cathode capacitance via the data line. A pixel circuit is configured so that a first mode in which the first sensing circuit becomes active and a second mode in which the second sensing circuit becomes active can be switched. The first mode and the second mode are switched according to an amount of light received by the photodiode included in each pixel circuit. Gain is controlled according to the amount of light received, in the first mode, and the storage time is controlled in the second mode.

Abstract: Each pixel cell (12) of an image sensor (10) is made of a 4-Tr structure, in which only one Tr for resetting a column (X) is so added to an ordinary 3-Tr APS as to reset only an arbitrary pixel selectively, thereby to confine the pixel size. When a pixel signal is to be read, the period, for which the pixel signals composing an ordinary image of one frame are read, is finely divided so that the pixel signals of the pixels receiving an ID light for the period are read out bit by bit and repeatedly. At this time, for only the column being read, an electric current is fed to a read amplifier in the pixel cell (12) or a variable gain amplifier in an output unit (14), thereby to suppress the power consumption. As a result, a lower power consumption and a higher pixel formation can be attained in an image pickup device for picking up an image and for acquiring the ID information of a light beacon existing in the image pickup range.

Abstract: In a system for data communication between an information terminal to be operated by a user and remote communication nodes, the present invention intends to suppress the power consumption of the information terminal. For that purpose, communication nodes 2, 3 and 4 each emit diffuse light carrying a pilot signal blinking at a low frequency to notify the presence of the communication node and an ID signal belonging to a higher frequency range, the ID signal containing inherent address etc. for identifying each communication node. A mobile phone 1 as the information terminal captures an image and processes the image data to detect the pilot signal of each communication node. Then, determining the position of each node and setting a limited range for reading the pixels around that position, the mobile phone 1 reads the detection signals of the pixels within the limited range at high speed and obtains identification information.

Abstract: After resetting the potential VPD of the photodiode (11) to the predetermined potential VRST, light is incident onto the photodiode (11) for a predetermined period to decrease the VPD corresponding to the amount of the incident light. After that, a declivous ramp voltage VRAMP is applied to the source terminal of the first MOS transistor (12) which is a common-source amplifier for reading out the VPD. When the voltage difference between the gate and source of the MOS transistor (12) exceeds a threshold voltage, the MOS transistor is turned on and the output suddenly decreases. If a signal having a pulse width from the starting point of the sweep of the ramp voltage to the sudden lowering point of the output is generated, the pulse width depends on the amount of the incident light. With the signal readout of this PWM method, it is possible to lower the power consumption while a wide dynamic range is maintained, and to downsize the picture cells to achieve a higher number of picture cells.

Abstract: The uppermost metallic wiring layer in light-blocking layers constituted by multilevel metallic wiring that prevents light from impinging on areas other than the light-receiving area of a photodiode in each picture cell is used as a measurement electrode to be directly contacted with a specimen to measure electrical signals. Furthermore, in each picture cell including a circuit for reading out electrical signals collected through the measurement electrode, another circuit for reading out electrical signals generated by the photodiode is provided in an independent or shared form. This configuration enables the photodiode for optical measurements and the measurement electrode for electrical measurements to be provided in every picture cell.

Abstract: A pixel includes a photodiode, an overflow circuit, a first sensing circuit, and a second sensing circuit. The first sensing circuit charges and discharges a cathode capacitance by a photocurrent flowing through a photodiode, and amplifies an obtained voltage by a source follower amplifier so as to be outputted to a data line. The second sensing circuit charges and discharged the cathode capacitance by the photocurrent flowing through the photodiode, and outputs electric charge stored in the cathode capacitance via the data line. A pixel circuit is configured so that a first mode in which the first sensing circuit becomes active and a second mode in which the second sensing circuit becomes active can be switched. The first mode and the second mode are switched according to an amount of light received by the photodiode included in each pixel circuit. Gain is controlled according to the amount of light received, in the first mode, and the storage time is controlled in the second mode.

Abstract: For an information terminal to be operated by users for collecting predetermined pieces of information from remote information devices by free-space optical communication, the present invention provides a technique for suppressing the power consumption of the information terminal by minimizing the amount of calculation performed to collect the aforementioned information. According to the present invention, each information device emits ID light on which a low-frequency pilot signal is superimposed. The information terminal captures a series of frames of images including the ID light and locates the ID light within the images by the following steps: (1) creating multiple levels of binned images having different resolutions for each frame of the image; (2) calculating an evaluation index for each pixel within a target range of the binned images at each level, from the lowest to the highest resolution, where the target range is narrowed every time the process switches over to a lower level.

Abstract: Each pixel cell (12) of an image sensor (10) is made of a 4-Tr structure, in which only one Tr for resetting a column (X) is so added to an ordinary 3-Tr APS as to reset only an arbitrary pixel selectively, thereby to confine the pixel size. When a pixel signal is to be read, the period, for which the pixel signals composing an ordinary image of one frame are read, is finely divided so that the pixel signals of the pixels receiving an ID light for the period are read out bit by bit and repeatedly. At this time, for only the column being read, an electric current is fed to a read amplifier in the pixel cell (12) or a variable gain amplifier in an output unit (14), thereby to suppress the power consumption. As a result, a lower power consumption and a higher pixel formation can be attained in an image pickup device for picking up an image and for acquiring the ID information of a light beacon existing in the image pickup range.

Abstract: A vision regeneration assisting apparatus for regenerating vision by applying electrical stimulation to cells that compose a retina, the apparatus comprising: a substrate formed in a thin plate shape of insulating and bendable material, provided with a plurality of first lead wires being wired therein and an electrode for outputting an electrical stimulation pulse signal being provided at one end of each of the first lead wires; a multiplexer for distributing the electrical stimulation pulse signal to each electrode; a base formed of sealing and insulating material, one face of which being united to the substrates and the other face of which being united with the multiplexer, and provided with a plurality of second lead wires for connecting the multiplexer and each of the first lead wires in the substrate being wired therein; and a cap formed of sealing material, and united to the base so that the multiplexer is to be hermetically sealed.

Abstract: A visual restoration aiding device for restoring vision of a patient comprises: a plurality of substrates which are placed on or under a retina of a patient's eye; a plurality of electrodes which are mounted on each substrate to apply an electrical stimulation pulse signal to cells constituting the retina; and a connecting unit which has flexibility and connects the substrates.

Abstract: In a system for data communication between an information terminal to be operated by a user and remote communication nodes, the present invention intends to suppress the power consumption of the information terminal. For that purpose, communication nodes 2, 3 and 4 each emit diffuse light carrying a pilot signal blinking at a low frequency to notify the presence of the communication node and an ID signal belonging to a higher frequency range, the ID signal containing inherent address etc. for identifying each communication node. A mobile phone 1 as the information terminal captures an image and processes the image data to detect the pilot signal of each communication node. Then, determining the position of each node and setting a limited range for reading the pixels around that position, the mobile phone 1 reads the detection signals of the pixels within the limited range at high speed and obtains identification information.