Patents by Inventor Jun Okumura
Jun Okumura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6453104Abstract: An optical fiber cable having a diameter of D1 (mm) and comprising an adhesion layer 0.5 to 200 &mgr; in thickness, a primary coating layer, and a secondary coating layer, all sequentially formed on the outer circumference of an optical fiber constituted on the outermost layer thereof by vinylidene fluoride polymer, wherein D1/D2=1.2 to 3.5 (the diameter of the optical fiber is Da (mm), the thickness of the adhesion layer d (mm), and Da+2d=D2); and an optical fiber cable with a plug using this optical fiber. Accordingly, these optical fiber cables are excellent in flame resistance, difficult in separating an optical fiber thereof from coating layers, and not likely to cause a pistoning phenomenon. An optical fiber may consist of a core, a sheath formed on the periphery of the core and a protection layer formed on the periphery of the sheath.Type: GrantFiled: August 28, 2001Date of Patent: September 17, 2002Assignee: Mitsubishi Rayon Co., Ltd.Inventors: Katsuhiko Shimada, Kazuki Nakamura, Takeshi Kitayama, Takara Yamamoto, Hiroe Kubo, Jun Okumura
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Patent number: 5963701Abstract: This invention relates to a plastic optical fiber having a three-layer structure comprising a core, a cladding and a protective layer wherein the core material is polymethyl methacrylate and the cladding material is a copolymer composed of 20 to 45% by weight of long-chain fluoroalkyl methacrylate units represented by the following formula (1), 54 to 79% by weight of methyl methacrylate units, and 0.05 to 2% by weight of methacrylic acid units. This invention also relates to a plastic optical fiber cable having a four-layer structure wherein the optical fiber cable is produced by covering the aforesaid optical fiber with a jacket layer.CH.sub.2 .dbd.C(CH.sub.3)--COO--(CH.sub.2).sub.2 (CF.sub.2).sub.7 CF.sub.Type: GrantFiled: November 14, 1997Date of Patent: October 5, 1999Assignee: Mitsubishi Rayon Co., Ltd.Inventors: Kazuki Nakamura, Jun Okumura, Kikue Irie, Makoto Muro, Jun Kamo, Katsuhiko Shimada
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Patent number: 4874856Abstract: This invention provides novel cephalosporanic acids and esters thereof having the general formula ##STR1## wherein R.sup.2 is hydrogen, or lower acyl, R.sup.3 is hydrogen, or lower alkanoyloxy, andR.sup.4 is hydrogen, 5-methyl-2-oxo-1,3-dioxolen-4-ylmethyl, 1-(ethoxycarbonyloxy)ethyl,1-(pivaloyloxy)ethyl, 1-(cyclohexylacetoxy)ethyl, or 1-(cyclohexyloxycarbonyloxy) ethyl. These compounds, especially esters, are useful as broad spectrum antibiotics in the treatment and prevention of infectious diseases of mammals, and for other purposes known in the art. The acids (R.sup.4 is hydrogen) are useful as intermediates for making the esters.Type: GrantFiled: August 17, 1987Date of Patent: October 17, 1989Assignee: Bristol-Myers CompanyInventors: Seiji Iimura, Yoshio Abe, Jun Okumura, Takayuki Naito, Hajime Kamachi
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Patent number: 4751295Abstract: 7-[2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(substituted)-iminoacetamido]-3-[3-( quaternaryammonio)-1-propen-1-yl]-3-cephem-4-carboxylates of the formula ##STR1## in which R.sup.1 and R.sup.2 are defined herein and --.sup..sym. N.tbd.Q is a quaternary ammonio group as defined herein, and salts, solvates, hydrates and esters thereof, are potent antibacterial agents. Processes for their preparation and intermediates in such processes are described.Type: GrantFiled: October 17, 1986Date of Patent: June 14, 1988Assignee: Bristol-Myers CompanyInventors: Masahisa Oka, Haruhiro Yamashita, Jun Okumura, Takayuki Naito
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Patent number: 4708955Abstract: This invention provides novel cephalosporanic acids and esters thereof having the general formula ##STR1## wherein R.sup.2 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, cyclo(lower)alkyl or acyl, R.sup.3 is hydrogen, lower alkyl, lower alkoxy, lower alkanoyloxy, andR.sup.4 is hydrogen, pivaloyloxymethyl, acetoxymethyl, 1-acetoxyethyl, 5-methyl-2-oxo-1, 3-dioxolen-4-ylmethyl or 4-glycyloxybenzoyloxymethyl. These compounds, especially esters, are useful as broad spectrum antibiotics in the treatment and prevention of infectious diseases of mammals, and for other purposes known in the art.Type: GrantFiled: June 24, 1985Date of Patent: November 24, 1987Assignee: Bristol-Myers CompanyInventors: Seiji Iimura, Yoshio Abe, Jun Okumura, Takayuki Naito, Hajime Kamachi
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Patent number: 4699979Abstract: This invention provides novel cephalosporin intermediates, 7.beta.-amino-3-[(Z)-1-propen-1-y1]-3-cephem-4-carboxylic acid and esters thereof having the general formula ##STR1## wherein the configuration of the 3-propenyl group is Z sometimes referred to as cis- and R is hydrogen or a conventional carboxy-protected group, or a physiologically hydrolyzable esterifying group, and acid addition salts thereof and the metal salts of the foregoing substance wherein R is hydrogen. These compounds are useful as intermediates for preparation of orally active cephalosporins.Type: GrantFiled: March 25, 1986Date of Patent: October 13, 1987Assignee: Bristol-Meyers CompanyInventors: Hideaki Hoshi, Jun Okumura, Takayuki Naito, Yoshio Abe, Shimpei Aburaki
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Patent number: 4661590Abstract: 3-[(Z)-1-Propen-1-yl]-7-acylamido cephalosporins in which the 7-acyl group is phenylglycyl or substituted phenylglycyl are orally active antibiotics against Gram+ and Gram- bacteria.Type: GrantFiled: July 31, 1985Date of Patent: April 28, 1987Assignee: Bristol-Myers CompanyInventors: Hideaki Hoshi, Jun Okumura, Takayuki Naito, Yoshio Abe, Shimpei Aburaki
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Patent number: 4659812Abstract: Temperature stable crystalline mono-hydrochloric and sulfuric acid addition salts of 7-amino-3-(1-methylpyrrolidinio)methyl-3-cephem-4-carboxylate substantially free of .DELTA..sup.2 isomer are intermediates for the preparation of broad spectrum 7-[.alpha.-(2-aminothiazol-4-yl)-.alpha.-(Z)-methoxyiminoacetamido]-3-[(1- methyl-1-pyrrolidinio)methyl]-3-cephem-4-carboxylates.Type: GrantFiled: August 20, 1985Date of Patent: April 21, 1987Assignee: Bristol-Myers CompanyInventors: Shimpei Aburaki, Yukio Narita, Jun Okumura, Takayuki Naito, Donald G. Walker
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Patent number: 4591641Abstract: 3-[(Z)-1-Propen-1-yl]-7-acylamido cephalosporins in which the 7-acyl group is phenylglycyl or substituted phenylglycyl are orally active antibiotics against Gram+ and Gram- bacteria.Type: GrantFiled: March 18, 1985Date of Patent: May 27, 1986Assignee: Bristol-Myers CompanyInventors: Hideaki Hoshi, Jun Okumura, Takayuki Naito, Yoshio Abe, Shimpei Aburaki
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Patent number: 4525473Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is hydrogen or a conventional amino-protecting group, R.sup.2 is a straight or branched chain alkyl, alkenyl or alkynyl containing from 1 to 4 carbon atoms, and ##STR2## is a quaternary ammonio group as described herein, and nontoxic pharmaceutically acceptable salts, physiologically hydrolyzable esters and solvates thereof, as well as processes for their preparation, are disclosed. The compounds in which R.sup.1 is hydrogen are potent antibacterial agents.Type: GrantFiled: March 30, 1983Date of Patent: June 25, 1985Assignee: Bristol-Myers CompanyInventors: Shimpei Aburaki, Hajime Kamachi, Yukio Narita, Jun Okumura, Takayuki Naito
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Patent number: 4520022Abstract: 3-[(Z)-1-Propen-1-yl]-7-acylamido cephalosporins in which the 7-acyl group is phenylglycyl or substituted phenylglycyl are orally active antibiotics against Gram+ and Gram- bacteria.Type: GrantFiled: December 28, 1983Date of Patent: May 28, 1985Assignee: Bristol-Myers CompanyInventors: Hideaki Hoshi, Jun Okumura, Takayuki Naito, Yoshio Abe, Shimpei Aburaki
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Patent number: 4507487Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is hydrogen or a conventional amino-protecting group, R.sup.2 is a straight or branched chain alkyl group containing from 1 to 4 carbon atoms, allyl, 2-butenyl, 3-butenyl, propargyl, 2-butynyl, 3-butynyl, cycloalkyl containing from 3 to 6 carbon atoms or a group of the formula ##STR2## in which R.sup.3 and R.sup.4 each are independently hydrogen, methyl or ethyl, or R.sup.3 and R.sup.4, taken together with the carbon atom to which they are attached, may be a cycloalkylidene ring containing from 3 to 6 carbon atoms or a substituted cyclobutylidene ring of the formula ##STR3## wherein X is halogen, hydroxy or (lower)alkoxy, and R.sup.5 and R.sup.Type: GrantFiled: September 26, 1983Date of Patent: March 26, 1985Assignee: Bristol-Myers CompanyInventors: Hajime Kamachi, Jun Okumura, Takayuki Naito, Masahisa Oka, Haruhiro Yamashita
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Patent number: 4500526Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is hydrogen or a conventional amino-protecting group, R.sup.2 is one of various alkyl, alkenyl, alkynyl, cycloalkyl, carboxyalkyl or carboxycycloalkyl moieties described herein, and R.sup.5 is hydrogen, amino, carboxy, formyl, carbamoyl, guanidino, amidino or one of various alkyl, alkoxy, alkylthio or substituted amino moieties described herein, and nontoxic pharmaceutically acceptable acid addition salts, physiologically hydrolyzable esters and solvates thereof, as well as processes for their preparation, are disclosed. The compounds in which R.sup.1 is hydrogen are potent antibacterial agents.Type: GrantFiled: October 13, 1983Date of Patent: February 19, 1985Assignee: Bristol-Myers CompanyInventors: Kiyoto Imae, Shimpei Aburaki, Yukio Narita, Jun Okumura, Takayuki Naito
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Patent number: 4486586Abstract: 7-{(Z)-2-(2-Aminothiazol-4-yl)-2-[(substituted)oxyimino]acetamido}-3-[3-(qu aternary ammonio)-1-propen-1-yl]-3-cephem-4-carboxylates and salts, esters and solvates thereof, having potent antibacterial activity, are provided. Processes for their preparation and intermediates in their preparation also are disclosed.Type: GrantFiled: February 10, 1983Date of Patent: December 4, 1984Assignee: Bristol-Myers CompanyInventors: Yukio Narita, Seiji Iimura, Shimpei Aburaki, Jun Okumura, Takayuki Naito
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Patent number: 4474954Abstract: Potent antibacterial agents of the formula ##STR1## wherein R is methyl, ethyl or isopropyl, and their pharmaceutically acceptable salts, physiologically hydrolyzable esters and solvates, and processes for their preparation, are described.Type: GrantFiled: December 6, 1982Date of Patent: October 2, 1984Assignee: Bristol-Myers CompanyInventors: Hajime Kamachi, Jun Okumura, Takayuki Naito, Masahisa Oka
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Patent number: 4457929Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is hydrogen or a conventional amino-protecting group, R.sup.2 and R.sup.3 each are independently methyl or ethyl, and R.sup.4 is methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, allyl, 2-butenyl, 3-butenyl, 2-hydoxyethyl, 3-hydroxypropyl, 2-(dimethylamino)ethyl, pyridylmethyl, pyridylethyl, benzyl or phenethyl, and nontoxic pharmaceutically acceptable acid addition salts and solvates thereof, as well as processes for their preparation, are disclosed. The compounds in which R.sup.1 is hydrogen are potent antibacterial agents.Type: GrantFiled: March 29, 1982Date of Patent: July 3, 1984Assignee: Bristol-Myers CompanyInventors: Hajime Kamachi, Jun Okumura, Takayuki Naito
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Patent number: 4406899Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is hydrogen or a conventional amino-protecting group, and R.sup.2 is a straight or branched chain alkyl group containing from 1 to 4 carbon atoms, allyl, 2-butenyl or 3-butenyl, and nontoxic pharmaceutically acceptable salts and solvates thereof, as well as processes for their preparation, are disclosed. The compounds in which R.sup.1 is hydrogen are potent antibacterial agents.Type: GrantFiled: March 4, 1982Date of Patent: September 27, 1983Assignee: Bristol-Myers CompanyInventors: Shimpei Aburaki, Hajime Kamachi, Yukio Narita, Jun Okumura, Takayuki Naito
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Patent number: 4394503Abstract: Potent antibacterial agents of the formula ##STR1## wherein R is methyl, ethyl or isopropyl, and their pharmaceutically acceptable salts, physiologically hydrolyzable esters and solvates, and processes for their preparation, are described.Type: GrantFiled: December 7, 1981Date of Patent: July 19, 1983Assignee: Bristol-Myers CompanyInventors: Hajime Kamachi, Jun Okumura, Takayuki Naito, Masahisa Oka
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Patent number: 4316024Abstract: Certain cephalosporins having a heterocyclicthiomethyl group at the 3-position such as cefoperazone are prepared by reacting a solution of a 7-acylamidocephalosporanic acid having a free amino group as part of said acyl substituent with about an equi-molar amount of the thiolester ##STR1## wherein --S-Het is the desired conventional heterocyclicthio group which displaces the 3-acetoxy group of the starting acid and ##STR2## is the conventional acyl group which displaces a hydrogen on the free amino group which is part of the acyl substituent of the starting 7-acylamidocephalosporanic acid.Type: GrantFiled: September 15, 1980Date of Patent: February 16, 1982Assignee: Bristol-Myers CompanyInventors: Seiji Iimura, Jun Okumura, Takayuki Naito
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Patent number: 4288590Abstract: 7-[D-.alpha.-(4-Hydroxy-1,5-naphthyridine-3-carboxamido)-.alpha.-phenyl (and thienyl and substituted phenyl) acetamido]-3-(2-, 3- or 4-N,N-dimethylaminomethyl-pyridinium)methyl-3-cephem-4-carboxylates were synthesized and found to have potent antibacterial activity in vitro especially against many strains of Pseudomonas aeruginosa.Type: GrantFiled: February 14, 1980Date of Patent: September 8, 1981Assignee: Bristol-Myers CompanyInventors: Masahisa Oka, Jun Okumura, Takayuki Naito