Patents by Inventor Jun-Seock Son

Jun-Seock Son has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Abietane diterpenoid compound, and composition comprising extract of torreya nucifera, or abietane diterpenoid compounds or terpenoid compounds isolated from them for prevention and treatment of cardiovascular disease
    Patent number: 7825162
    Abstract: A method for treating cardiovascular disease, including hyperlipidemia and atherosclerosis, using abietane diterpenoid compound or terpenoid compound isolated from Torreya nucifera as an effective ingredient. The abietane diterpenoid compound or terpenoid compound isolated from Torreya nucifera not only excellently inhibits oxidation of low-density lipoprotein (LDL), but also effectively inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity.
    Type: Grant
    Filed: November 5, 2008
    Date of Patent: November 2, 2010
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Tae-Sook Jeong, Woo-Song Lee, Hyoung-Chin Kim, Yang-Kyu Choi, Ju-Ryoung Kim, So-Jin An, Kyoung-Ran Im, Ki-Chang Jang, Og-Sung Moon, Jun-Seock Son
  • Abietane diterpenoid compound, and composition comprising extract of , or abietane diterpenoid compounds or terpenoid compounds isolated from them for prevention and treatment of cardiovascular disease
    Patent number: 7820212
    Abstract: The present invention relates to a method for treating a cardiovascular disease, such as hyperlipidemia or atherosclerosis, with a pharmaceutically effective amount of an extract of Torreya nucifera or abietane diterpenoid compound or terpenoid compound isolated from the same as an effective ingredient. Torreya nucifera extracts, abietane diterpenoid compound, or terpenoid compound isolated from the extracts were prepared by extracting Torreya nucifera leaves, stems, or seeds with water, alcohol, or mixed solution of water and alcohol, which is further fractionized with n-hexane, chloroform and etheyl acetate in that order. Further, the present invention provides a method for inhibiting an oxidation of low-density lipoprotein (LDL) and inhibiting Acyl-CoA:cholesterol acyltransferase (ACAT) using an extract of Torreya nucifera or abietane diterpenoid compound or terpenoid compound isolated from the same as an effective ingredient.
    Type: Grant
    Filed: July 29, 2008
    Date of Patent: October 26, 2010
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Tae-Sook Jeong, Woo-Song Lee, Hyoung-Chin Kim, Yang-Kyu Choi, Ju-Ryoung Kim, So-Jin An, Kyoung-Ran Im, Ki-Chang Jang, Og-Sung Moon, Jun-Seock Son
  • Abietane diterpenoid compound, and composition comprising extract of , or abietane diterpenoid compounds or terpenoid compounds isolated from them for prevention and treatment of cardiovascular disease
    Patent number: 7517542
    Abstract: The present invention relates to a composition for the prevention and the treatment of cardiovascular disease containing extracts of T. nucifera or abietane diterpenoid compound or terpenoid compound isolated from the same as an effective ingredient. T. nucifera extracts or abietane diterpenoid compound or terpenoid compound isolated from the same of the present invention not only shows excellent anti-oxidative activity to LDL but also effectively inhibits ACAT activity. Further, T. nucifera extracts of the present invention reduce blood LDL cholesterol and total cholesterol. Therefore, the composition of the present invention can be effectively used for the prevention and the treatment of cardiovascular diseases including hyperlipidemia and atherosclerosis caused by the LDL oxidation and the synthesis and accumulation of cholesteryl ester.
    Type: Grant
    Filed: February 22, 2005
    Date of Patent: April 14, 2009
    Assignee: Korea Research Institute of Bioscience
    Inventors: Tae-Sook Jeong, Woo-Song Lee, Hyoung-Chin Kim, Yang-Kyu Choi, Ju-Ryoung Kim, So-Jin An, Kyoung-Ran Im, Ki-Chang Jang, Og-Sung Moon, Jun-Seock Son
  • NOVEL ABIETANE DITERPENOID COMPOUND, AND COMPOSITION COMPRISING EXTRACT OF TORREYA NUCIFERA, OR ABIETANE DITERPENOID COMPOUNDS OR TERPENOID COMPOUNDS ISOLATED FROM THEM FOR PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE
    Publication number: 20090062384
    Abstract: The present invention relates to a composition for the prevention and the treatment of cardiovascular disease containing extracts of T. nucifera or abietane diterpenoid compound or terpenoid compound isolated from the same as an effective ingredient. T. nucifera extracts or abietane diterpenoid compound or terpenoid compound isolated from the same of the present invention not only shows excel lent anti-oxidative activity to LDL but also effectively inhibits ACAT activity. Further, T. nucifera extracts of the present invention reduce blood LDL cholesterol and total cholesterol. Therefore, the composition of the present invention can be effectively used for the prevention and the treatment of cardiovascular diseases including hyperlipidemia and atherosclerosis caused by the LDL oxidation and the synthesis and accumulation of cholesteryl ester.
    Type: Application
    Filed: November 5, 2008
    Publication date: March 5, 2009
    Applicant: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Tae-Sook Jeong, Woo-Song Lee, Hyoung-Chin Kim, Yang-Kyu Choi, Ju-Ryoung Kim, So-Jin An, Kyoung-Ran Im, Ki-Chang Jang, Og-Sung Moon, Jun-Seock Son
  • NOVEL ABIETANE DITERPENOID COMPOUND, AND COMPOSITION COMPRISING EXTRACT OF TORREYA NUCIFERA, OR ABIETANE DITERPENOID COMPOUNDS OR TERPENOID COMPOUNDS ISOLATED FROM THEM FOR PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE
    Publication number: 20080299238
    Abstract: The present invention relates to a composition for the prevention and the treatment of cardiovascular disease containing extracts of T. nucifera or abietane diterpenoid compound or terpenoid compound isolated from the same as an effective ingredient. T. nucifera extracts or abietane diterpenoid compound or terpenoid compound isolated from the same of the present invention not only shows excellent anti-oxidative activity to LDL but also effectively inhibits ACAT activity. Further, T. nucifera extracts of the present invention reduce blood LDL cholesterol and total cholesterol. Therefore, the composition of the present invention can be effectively used for the prevention and the treatment of cardiovascular diseases including hyperlipidemia and atherosclerosis caused by the LDL oxidation and the synthesis and accumulation of cholesteryl ester.
    Type: Application
    Filed: July 29, 2008
    Publication date: December 4, 2008
    Applicant: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Tae-Sook Jeong, Woo-Song Lee, Hyoung-Chin Kim, Yang-Kyu Choi, Ju-Ryoung Kim, So-Jin An, Kyoung-Ran Im, Ki-Chang Jang, Og-Sung Moon, Jun-Seock Son
  • Novel abietane diterpenoid compound, and composition comprising extract of torreya nucifera, or abietane diterpenoid compounds or terpenoid compounds isolated from them for prevention and treatment of cardiovascular disease
    Publication number: 20070190192
    Abstract: The present invention relates to a composition for the prevention and the treatment of cardiovascular disease containing extracts of T. nucifera or abietane diterpenoid compound or terpenoid compound isolated from the same as an effective ingredient. T. nucifera extracts or abietane diterpenoid compound or terpenoid compound isolated from the same of the present invention not only shows excellent anti-oxidative activity to LDL but also effectively inhibits ACAT activity. Further, T. nucifera extracts of the present invention reduce blood LDL cholesterol and total cholesterol. Therefore, the composition of the present invention can be effectively used for the prevention and the treatment of cardiovascular diseases including hyperlipidemia and atherosclerosis caused by the LDL oxidation and the synthesis and accumulation of cholesteryl ester.
    Type: Application
    Filed: February 22, 2005
    Publication date: August 16, 2007
    Inventors: Tae-Sook Jeong, Woo-Song Lee, Hyoung-Chin Kim, Yang-Kyu Choi, Ju-Ryoung Kim, So-Jin An, Kyoung-Ran Im, Ki-Chang Jang, Og-Sung Moon, Jun-Seock Son