Abstract: Provided herein are compounds and compositions for treating, managing or preventing coronaviral related diseases. In particular, provided herein are compounds which are inhibitors of SARS-CoV-2 main protease (Mpro), pharmaceutical compositions comprising such compounds, method for synthesizing such compounds and methods of using such compounds and compositions for the treatment, management or prevention of coronaviral related diseases.

Abstract: A method for preparing an emergency call, a device for preparing an emergency call, and a storage medium are presented. The method includes detecting that a user of a device has initiated an emergency call, obtaining an indication of a current geographical location of the device, and, in response to the detecting and based on the obtained indication, selecting an emergency number to be called for the emergency call.

Abstract: Provided is an airflow disturbance type carbon fiber spreading device. The device includes an unwinding module, an unwinding tension control module, an airflow disturbance spreading module, a winding tension stabilizing module, a deviation correction module and a winding module which are sequentially arranged along a feeding direction. The spreading mechanism includes an airflow disturbance spreading module, the airflow disturbance spreading module includes two airflow disturbance spreading assemblies, each airflow disturbance spreading assembly includes a centrifugal fan, the centrifugal fan communicates with the bottom of an airflow duct, and three spreading guide shafts are arranged side by side on the top of the airflow duct. A tension adjusting assembly is provided between the airflow disturbance spreading assemblies. A seventh spreading guide shaft (13) is located at the upper port of an airflow duct I (25) and is connected to a slider module II (34).

Abstract: A modular furniture assembly has a modular universal base, an armrest module, and a modular recliner. The armrest is modularly coupled to one side of the modular universal base and includes an armrest member, a stepped member, a base horizontal member, and a base vertical plate. The modular recliner is coupled to another side of the modular universal base, and includes a recliner base and a backrest module. The recliner base has a plurality of frames that are interconnected and mechanically attached to each other. The recliner base includes a recessed surface that forms a transverse gap within the recliner base, and a top support having a flat top surface aligned with top edges of the plurality of frames. The backrest module has two backrest sections with end plates configured to move, respectively, along the recessed surface.

Abstract: Provided are a lipid and a composition used for delivery. Specifically provided is a compound represented by formula I or a salt thereof, wherein R1 to R3, H1 to H3, L1, and L2 are as defined in the description.

Abstract: The invention discloses a method for synthesizing 1,7-naphthyridine derivatives, which relates to the technical field of synthesizing pharmaceutical intermediates and organic chemical intermediates, wherein the method includes: (1) 2-chloro-3-amino-pyridine being used as Compound I as a starting material, and protecting an amino group to prepare Compound II; (2) the Compound II reacting with an aldehydation reagent under alkaline conditions to obtain Compound III; (3) cyclizing the Compound III with acrylate compounds under the action of Lewis acid to prepare compound IV.

Abstract: The present invention relates to radiolabeled LPA1 receptor antagonists of Formula (I): or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein, which are useful for the quantitative imaging of LPA1 receptors in mammals.

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

Abstract: An article may include a substrate, such as a silicon-containing ceramic matrix composite, an environmental barrier coating (EBC) layer on the substrate, and a CMAS-resistant EBC layer on the EBC layer. The EBC layer may include at least one rare-earth disilicate (REDS). The CMAS-resistant EBC layer may include at least one rare-earth monosilicate (REMS) configured to react with CMAS to form crystalline reaction products. The CMAS-resistant EBC layer may include a plurality of vertical cracks extending from a surface of the CMAS-resistant EBC layer at least partially into the CMAS-resistant EBC layer. Additionally, or alternatively, the EBC layer may include a plurality of vertical cracks extending from a surface of the EBC layer into at least a portion of the EBC layer.

Abstract: Disclosed are a tricyclic derivative and a preparation method therefor and an application thereof. Specifically, disclosed are a compound shown in formula (I) and an optical isomer thereof or a pharmaceutically acceptable salt thereof, and an application of the compound as an Autotaxin inhibitor.

Abstract: Provided are a recombinant expression vector for whooping cough antigens, an engineered bacterium and use thereof. The recombinant expression vector for whooping cough antigens comprises a protein expression cassette for pertactin, a gene for resistance screening, and an upstream recombinant nucleic acid fragment and a downstream recombinant nucleic acid fragment of filamentous haemagglutinin gene, wherein the protein expression cassette for pertactin is located between the upstream recombinant nucleic acid fragment and the downstream recombinant nucleic acid fragment of the filamentous haemagglutinin gene, and the upstream recombinant nucleic acid fragment and the downstream recombinant nucleic acid fragment of the filamentous haemagglutinin gene can undergo homologous recombination with the upstream and downstream of the filamentous haemagglutinin gene, respectively.

Abstract: The present invention relates to a process for producing succinic anhydride by maleic anhydride hydrogenation, comprising (1) feeding a maleic anhydride solution and a hydrogen raw material respectively to a first-stage hydrogenation reactor from an upper liquid-phase feed port and a top gas-phase feed port of the first-stage hydrogenation reactor for a first-stage hydrogenation reaction to obtain a first-stage hydrogenation product; (2) feeding the first-stage hydrogenation product to a second-stage hydrogenation reactor for a second-stage hydrogenation reaction to obtain a second-stage hydrogenation product, optionally, before entering the second-stage hydrogenation reactor, subjecting the first-stage hydrogenation product to a first-stage gas-liquid separation to obtain a first-stage gas phase and a first-stage liquid phase, and then feeding the first-stage gas phase and the first-stage liquid phase respectively from a top gas-phase feed port and an upper liquid-phase feed port of the second-stage hydrogen

Abstract: The present invention provides compounds of Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

Abstract: A method for forming a memory device is provided. An alternating dielectric stack is formed on a substrate. The alternating dielectric stack includes a dielectric layer pair, and the dielectric layer pair includes a first dielectric layer and a second dielectric layer different from the first dielectric layer. A barrier structure extending vertically through the alternating dielectric stack and laterally separating the alternating dielectric stack into a first portion and a second portion is formed. The barrier structure has an unclosed shape. The first dielectric layer in the second portion of the alternating dielectric stack is replaced with a conductor layer to form an alternating conductor/dielectric stack including the conductor layer and a third dielectric layer. A through array contact structure extending vertically through the first portion of the alternating dielectric stack to the substrate is formed.

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

Abstract: A preparation method of a Pueraria lobata nano-silver composite hydrosol includes: dispersing Pueraria lobata powder in water, then heating to perform gelatinization, then adjusting a pH value, then sequentially adding an alkyl polyglucoside solution, a silver nitrate solution, and a sodium chloride solution, and performing a reaction by microwave heating to obtain the Pueraria lobata nano-silver composite hydrosol. The Pueraria lobata nano-silver composite hydrosol promotes seed germination of a Polygonatum Mill genus, and is applied in antibiotic detection and agricultural sterilization used as a fungicide.

Abstract: A computer implemented method includes granting a subscriber client access to a cloud service-based resource group within a subscriber controlled computing environment. The subscriber controlled computing environment has a virtual network. A direct network connection is established via the virtual network to a domain controller in the subscriber controlled computing environment. The virtual network is extended to a subscriber client virtual machine in a producer cloud service. The the subscriber client virtual machine is then joined with the virtual network. Access to the subscriber client virtual machine is provided via the subscriber controlled computing environment and virtual network.

Abstract: In one example, a method for forming an environmental barrier coating (EBC), thermal barrier coating (TBC), and/or abradable coating on a substrate. The method may include depositing a coating on a substrate to form an as-deposited coating, wherein the coating includes at least one of a TBC layer, an EBC layer, or an abradable coating layer; and heat treating the as-deposited coating at or above a first temperature for a first period of time following the deposition of the as-deposited coating on the substrate, wherein heat treating the as-deposited coating includes heating the as-deposited coating to or above the first temperature at a controlled heating rate, and wherein the controlled heating rate is selected such that the heat treated coating exhibits a compressive residual stress state upon cooling.

Abstract: An article having a coating system configured to inhibit or prevent crystallization of a thermally grown oxide (TGO) layer at the operating temperature of the article. An article includes a substrate defining a surface and a coating layer that includes a dopant configured to inhibit crystallization of a thermally grown oxide layer comprising amorphous silicon dioxide at an interface of the coating layer at the operating temperature of the article. The dopant includes an oxide or a nitride. By inhibiting or preventing TGO crystallization, the described coating systems may increase a useable life of the component.

Abstract: Disclosed are a method of PCB sectional preshrinking, a device, an equipment and a computer-readable storage medium. The method includes: obtaining a PCB raw data and a preset accuracy requirement; determining a preshrinking compensation value according to the PCB raw data and the preset accuracy requirement; determining a first sectional length according to the PCB raw data and the preshrinking compensation value; determining a preshrinking compensation ratio according to the preshrinking compensation value and the first sectional length; determining a second sectional length according to the PCB raw data, the first sectional length and the preshrinking compensation ratio; and determining an optimization preshrinking design length according to the first sectional length and the second sectional length.