Abstract: The present invention relates to radiolabeled LPA1 receptor antagonists of Formula (I): or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein, which are useful for the quantitative imaging of LPA1 receptors in mammals.

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

Abstract: An article may include a substrate, such as a silicon-containing ceramic matrix composite, an environmental barrier coating (EBC) layer on the substrate, and a CMAS-resistant EBC layer on the EBC layer. The EBC layer may include at least one rare-earth disilicate (REDS). The CMAS-resistant EBC layer may include at least one rare-earth monosilicate (REMS) configured to react with CMAS to form crystalline reaction products. The CMAS-resistant EBC layer may include a plurality of vertical cracks extending from a surface of the CMAS-resistant EBC layer at least partially into the CMAS-resistant EBC layer. Additionally, or alternatively, the EBC layer may include a plurality of vertical cracks extending from a surface of the EBC layer into at least a portion of the EBC layer.

Abstract: Provided are a recombinant expression vector for whooping cough antigens, an engineered bacterium and use thereof. The recombinant expression vector for whooping cough antigens comprises a protein expression cassette for pertactin, a gene for resistance screening, and an upstream recombinant nucleic acid fragment and a downstream recombinant nucleic acid fragment of filamentous haemagglutinin gene, wherein the protein expression cassette for pertactin is located between the upstream recombinant nucleic acid fragment and the downstream recombinant nucleic acid fragment of the filamentous haemagglutinin gene, and the upstream recombinant nucleic acid fragment and the downstream recombinant nucleic acid fragment of the filamentous haemagglutinin gene can undergo homologous recombination with the upstream and downstream of the filamentous haemagglutinin gene, respectively.

Abstract: Disclosed are a tricyclic derivative and a preparation method therefor and an application thereof. Specifically, disclosed are a compound shown in formula (I) and an optical isomer thereof or a pharmaceutically acceptable salt thereof, and an application of the compound as an Autotaxin inhibitor.

Abstract: The present invention relates to a process for producing succinic anhydride by maleic anhydride hydrogenation, comprising (1) feeding a maleic anhydride solution and a hydrogen raw material respectively to a first-stage hydrogenation reactor from an upper liquid-phase feed port and a top gas-phase feed port of the first-stage hydrogenation reactor for a first-stage hydrogenation reaction to obtain a first-stage hydrogenation product; (2) feeding the first-stage hydrogenation product to a second-stage hydrogenation reactor for a second-stage hydrogenation reaction to obtain a second-stage hydrogenation product, optionally, before entering the second-stage hydrogenation reactor, subjecting the first-stage hydrogenation product to a first-stage gas-liquid separation to obtain a first-stage gas phase and a first-stage liquid phase, and then feeding the first-stage gas phase and the first-stage liquid phase respectively from a top gas-phase feed port and an upper liquid-phase feed port of the second-stage hydrogen

Abstract: The present invention provides compounds of Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

Abstract: A method for forming a memory device is provided. An alternating dielectric stack is formed on a substrate. The alternating dielectric stack includes a dielectric layer pair, and the dielectric layer pair includes a first dielectric layer and a second dielectric layer different from the first dielectric layer. A barrier structure extending vertically through the alternating dielectric stack and laterally separating the alternating dielectric stack into a first portion and a second portion is formed. The barrier structure has an unclosed shape. The first dielectric layer in the second portion of the alternating dielectric stack is replaced with a conductor layer to form an alternating conductor/dielectric stack including the conductor layer and a third dielectric layer. A through array contact structure extending vertically through the first portion of the alternating dielectric stack to the substrate is formed.

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

Abstract: A preparation method of a Pueraria lobata nano-silver composite hydrosol includes: dispersing Pueraria lobata powder in water, then heating to perform gelatinization, then adjusting a pH value, then sequentially adding an alkyl polyglucoside solution, a silver nitrate solution, and a sodium chloride solution, and performing a reaction by microwave heating to obtain the Pueraria lobata nano-silver composite hydrosol. The Pueraria lobata nano-silver composite hydrosol promotes seed germination of a Polygonatum Mill genus, and is applied in antibiotic detection and agricultural sterilization used as a fungicide.

Abstract: A computer implemented method includes granting a subscriber client access to a cloud service-based resource group within a subscriber controlled computing environment. The subscriber controlled computing environment has a virtual network. A direct network connection is established via the virtual network to a domain controller in the subscriber controlled computing environment. The virtual network is extended to a subscriber client virtual machine in a producer cloud service. The the subscriber client virtual machine is then joined with the virtual network. Access to the subscriber client virtual machine is provided via the subscriber controlled computing environment and virtual network.

Abstract: In one example, a method for forming an environmental barrier coating (EBC), thermal barrier coating (TBC), and/or abradable coating on a substrate. The method may include depositing a coating on a substrate to form an as-deposited coating, wherein the coating includes at least one of a TBC layer, an EBC layer, or an abradable coating layer; and heat treating the as-deposited coating at or above a first temperature for a first period of time following the deposition of the as-deposited coating on the substrate, wherein heat treating the as-deposited coating includes heating the as-deposited coating to or above the first temperature at a controlled heating rate, and wherein the controlled heating rate is selected such that the heat treated coating exhibits a compressive residual stress state upon cooling.

Abstract: An article having a coating system configured to inhibit or prevent crystallization of a thermally grown oxide (TGO) layer at the operating temperature of the article. An article includes a substrate defining a surface and a coating layer that includes a dopant configured to inhibit crystallization of a thermally grown oxide layer comprising amorphous silicon dioxide at an interface of the coating layer at the operating temperature of the article. The dopant includes an oxide or a nitride. By inhibiting or preventing TGO crystallization, the described coating systems may increase a useable life of the component.

Abstract: Disclosed are a method of PCB sectional preshrinking, a device, an equipment and a computer-readable storage medium. The method includes: obtaining a PCB raw data and a preset accuracy requirement; determining a preshrinking compensation value according to the PCB raw data and the preset accuracy requirement; determining a first sectional length according to the PCB raw data and the preshrinking compensation value; determining a preshrinking compensation ratio according to the preshrinking compensation value and the first sectional length; determining a second sectional length according to the PCB raw data, the first sectional length and the preshrinking compensation ratio; and determining an optimization preshrinking design length according to the first sectional length and the second sectional length.

Abstract: In one example, a method for forming a coating system including an environmental barrier coating (EBC) and abradable coating on a substrate. The method may include depositing the EBC on a ceramic or ceramic matrix composite (CMC) substrate to form an as-deposited EBC; heat treating the as-deposited EBC following the deposition of the as-deposited EBC on the substrate to form a heat treated EBC; and subsequently depositing an abradable coating on the heat treated EBC to form an as-deposited abradable coating. The as-deposited abradable coating may be heat treated to form a heat treated abradable coating.

Abstract: The present teaching relates to obtaining a model for identifying content matching a query. Training data are received which include queries, advertisements, and hyperlinks. A plurality of subwords are identified from each of the queries and a plurality of vectors for the plurality of subwords of each of the queries are obtained. Via a neural network, a vector for each of the queries is derived based on a plurality of vectors for the plurality of subwords of the query. A query/ads model is obtained via optimization with respect to an objective function, based on vectors associated with the plurality of subwords of each of the queries and vectors for the queries obtained from the neural network.

Abstract: The present disclosure relates to a process including introducing a feed to a catalyst and an activator to provide a solution in a continuous or semi-continuous reactor. The feed can include a solvent, and a first monomer that is propylene. The reactor can include polymerization conditions including a pressure of about 1 MPa to about 5 MPa and/or a temperature of about 60° C. to about 120° C. The solution can be circulated to form a biphasic product including a first portion and a second portion, the first portion having a propylene based polymer having a polydispersity index of about 1.5 to about 15, and weight average molecular weight (Mw) of about 50,000 g/mol or greater, according to GPC-4D.

Abstract: A computer implemented method includes granting a tenant administrator client machine access to a cloud hosted tenant service joined to a directory service. A bulk token for the tenant is obtained in response to a request received from the tenant administrator client machine. An identifier of an authorized tenant client to the cloud hosted tenant service is received and results in the provisioning of a tenant client virtual machine in a cloud service for the authorized tenant client in accordance with a specified provisioning package associated with the bulk token. The tenant client virtual machine is then joined to the directory service. On receipt of an authorized client token at the cloud hosted tenant service from a tenant client machine, the tenant client machine is provided a connection to the tenant client virtual machine.

Abstract: A method and a device for performing plane detection are provided. The method includes acquiring an input image, extracting features of the input image using a deep neural network and estimating a depth map of the input image based on the extracted features, performing region segmentation using the depth map to detect plane regions in the input image.