Abstract: This invention is in the field of medicinal chemistry and relates to a new class of small-molecules having a methyl-acetamido-propanamide structure (e.g., Formula I) which function as inhibitors of the SARS-CoV-2 main protease (Mpro), which function as therapeutics for the treatment of viral infection characterized with Mpro protease activity and/or expression (e.g., COVID-19), and which function as therapeutics for the treatment of other conditions characterized with Mpro protease activity and/or expression.

Abstract: Methods and compositions for modulating a target genome are disclosed.

Abstract: Provided is a fusion protein, comprising a protein having a hydrophobic region, a peptide linker, a protein fusion receptor. The peptide linker links the protein having a hydrophobic region to the protein fusion receptor. The protein fusion receptor is an Fc receptor fragment that specifically recognizes an Fc fragment of an antibody, and the protein having a hydrophobic region is a serum albumin. Also provided is a nano-assembly consisting of the fusion protein and a hydrophobic degradable polyester and a derivative thereof. Also provided is an application of the nano-assembly having excellent stability in an antibody delivery platform. The constructed nano-assembly platform is creatively applied in the preparation of immunotherapeutic drugs or therapeutic drugs for tumors or autoimmune diseases or inflammations.

Abstract: A first machine learning model is deployed in a first communication apparatus, and a second machine learning model is deployed in a second communication apparatus. First information is obtained that carries indication information of both a first transmission resource and a second transmission resource, wherein the first transmission resource is for the first communication apparatus to transmit a first output of the first machine learning model to the second communication apparatus, and wherein the second transmission resource is for the first communication apparatus to receive first feedback data that is from the second communication apparatus. The first feedback data includes a first gradient, wherein the first gradient is for updating the first machine learning model. The first communication apparatus transmits the first output to the second communication apparatus on the first transmission resource.

Abstract: Aspects of switching-cycle voltage deviation control for modular multilevel converters (MMCs) are described. In one example, an upper switching action of an upper power cell is determined within a time duration of a switching cycle for an MMC. In addition, a lower switching action of a lower power cell is determined within the time duration of the switching cycle for the MMC. In addition, a delay is generated between the upper switching action and the lower switching action to reduce capacitor voltage deviation between the upper power cell and the lower power cell during the switching cycle. The upper power cell is located in an upper arm of a phase leg of the MMC, while the lower power cell is located in a lower arm of the phase leg of the MMC.

Abstract: A preparation method of a zeolite/polyimide composite membrane includes: synthesizing a zeolite-doped polyamic acid precursor casting solution by condensation polymerization synthesis; coating a substrate with the obtained casting solution, and obtaining a zeolite/polyamic acid composite porous membrane by non-solvent induced phase separation; and obtaining the zeolite/polyimide composite membrane by performing thermal imidization on the zeolite/polyamic acid composite porous membrane through gradient heating.

Abstract: Obtain, at a computing device, a segment of computer code. With a classification module of a machine learning system executing on the computing device, determine a required annotation category for the segment of computer code. With an annotation generation module of the machine learning system executing on the computing device, generate a natural language annotation of the segment of computer code based on the segment of computer code and the required annotation category. Provide the natural language annotation to a user interface for display adjacent the segment of computer code.

Abstract: The present application provides a video signal identification method and apparatus, an electronic device and a readable storage medium. The method includes: reading a first register to obtain a format value of a video signal received (S100); in a case that the format value is shared by target video signals with multiple formats, configuring a second register according to at least one of the multiple formats for the target video signals, and detecting whether the video signal received is in a locked state (S110); and in response to configuring the second register according to a first target format and detecting that the video signal received is in the locked state, determining that a format of the video signal received is the first target format (S120).

Abstract: A preparation method and a device for a seawater desalination-seawater extraction uranium membrane lining are provided. The preparation method is as follow: the lining is configured as a finished product for standby through the following process, including cleaning, drying, restoration of circular, generating burrs, fixing the length of burrs; the device includes the first module, the second module, the third module, the fourth module and the fifth module. The present invention has the advantages of simple operation, short time, low cost and obvious treatment effect, the bonding strength between the separation function layer and the lining is enhanced, and the separation function layer is not easy to fall off, the physical damage resistance is greatly increased, it is not easy to fall off and the initial bubble point pressure of the prepared enhanced film is high.

Abstract: Terminal apparatus identification methods and apparatuses are described. An access stratum (AS) of a first communications apparatus sends first information to an AS of a second communications apparatus. The AS of the second terminal apparatus may identify a leader terminal apparatus based on the first information, so as to implement perception of the leader terminal.

Abstract: Provided are a display substrate and a detection method therefor, and a display apparatus. Compensation sub-circuits that are in one-to-one correspondence with each stage of a shift register are arranged in a gate driving circuit, and a first capacitor in each compensation sub-circuit is thus charged under the control of a detection input circuit when each stage of the shift register outputs a signal stage by stage; and an output control circuit is used to disconnect the compensation sub-circuit from a pull-up node of the corresponding stage of the shift register. The triggering of each stage of the shift register is stopped after each stage of the shift register (CR(n)) completes outputting, and the output control circuit provides a signal of a first power voltage end to the pull-up node of the corresponding stage of the shift register under the control of a second control end and the first capacitor.

Abstract: The present invention is directed to electrical circuits and methods. According to a specific embodiment, the present invention provides a voltage compensation mechanism for one or more single-phone avalanche diodes (SPADs). A reference voltage is generated based at least on an operating voltage of the SPADs. The reference voltage is coupled to a charge pump that generates a compensation voltage for the diodes. There are other embodiments as well.

Abstract: A communication method for data transmission in the internet of vehicles V2X and a related device. The method includes a first terminal device that receives first information from a first radio access network device, where the first information includes service information of a service of the first terminal device and a resource configuration mode on a sidelink, and there is a correspondence between the service information and the resource configuration mode on the sidelink. The first terminal device transmits, based on the correspondence, data corresponding to the service information on a sidelink transmission resource configured based on the resource configuration mode. The service information may be reliability information.

Abstract: Methods and compositions for modulating a target genome are disclosed.

Abstract: Analysis of samples for maliciousness is disclosed. A sample is executed and one or more network activities associated with executing the sample are recorded. The recorded network activities are compared to a malware profile. The malware profile comprises a set of network activities taken by a known malicious application during execution of the known malicious application. A verdict of “malicious” is assigned to the sample based at least in part on a determination that the recorded network activities match the malware profile.

Abstract: Disclosed is a wireless detection device for quickly positioning a throw-fill stone falling depth and long-term settlement in blasting silt-squeezing construction, including a gravity ball and a signal receiving, processing and controlling system. The gravity ball is internally provided with test mechanisms, signal collecting and transmitting apparatuses and batteries. Also disclosed is a wireless detection method implemented using the above wireless detection device. The device and the method can detect the throw-fill stone falling depth and distribution situation in a blasting silt-squeezing construction process in real time, so that the effect evaluation and quality control of blasting silt-squeezing can be monitored in real time, the situation that the falling of throw-fill stones is incomplete can be acquired in time, monitoring data support can be provided for corresponding processing measures, and long-term settlement and other monitoring can be carried out.

Abstract: Embodiment techniques map parity bits to sub-channels based on their row weights. In one example, an embodiment technique includes polar encoding, with an encoder of the device, information bits and at least one parity bit using the polar code to obtain encoded data, and transmitting the encoded data to another device. The polar code comprises a plurality of sub-channels. The at least one parity bit being placed in at least one of the plurality of sub-channels. The at least one sub-channel is selected from the plurality of sub-channels based on a weight parameter.

Abstract: Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, and X, are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.

Abstract: Described herein are embodiments of a reinforcement learning based large-scale multi-objective ranking system. Embodiments of the system may be used for optimizing short-video recommendation on a video sharing platform. Multiple competing ranking objective and implicit selection bias in user feedback are the main challenges in real-world platform. In order to address those challenges, multi-gate mixture of experts (MMoE) and soft actor critic (SAC) are integrated together into a MMoE_SAC system. Experiment results demonstrate that embodiments of the MMoE_SAC system may greatly reduce a loss function compared to systems only based on single strategies.