Abstract: The present invention relates to a compound of formula (I) capable of inhibiting plasmin activity and having blood coagulation and hemostasis activity, and a pharmaceutically acceptable salt, hydrate, isomer, prodrug and mixture thereof, wherein R1 to R3 are as defined in the description.

Abstract: The present disclosure relates to the field of biomedicine, in particular to the use of MCM8-cGAS-STING-IFN-I signal pathway as a disease target, including the use in the preparation of an animal model of a disease or the preparation of a product for the diagnosis, prevention, or treatment of a disease. In particular, the present disclosure comprises the use of a reagent for quantitatively detecting the gene expression or protein expression or protein activity of MCM8 in the preparation of a product for the diagnosis of a disease caused by dysfunctional mitophagy or caused by abnormal activation of cGAS-STING-IFN-I signaling pathway.

Abstract: An information processing method, a server, and a computer storage medium are provided. The method includes: generating a first information identification code according to first information, the first information representing an information source; providing the first information identification code to a terminal; receiving a first request from the terminal and allowing a terminal user of the terminal to follow an information service, the first request carrying the first information; and recording the first information and tracking and obtaining conversion information of the information source according to the first information.

Abstract: The disclosure relates to a decentralized cyber-physical system including a managing unit and a plurality of components. The managing unit includes a root resilient manager including a root contract and a sub-contract generator. The sub-contract generator is configured to decompose the root contract into a plurality of sub-contracts and assign the plurality of sub-contracts to the plurality of components, respectively. Each component includes at least one observer configured to monitor if the property of the individual component violates the sub-contracts corresponding thereto. When one of the plurality of sub-contracts violates during the runtime of the decentralized cyber-physical system, the root resilience manager issues an alarm.

Abstract: The present invention provides compounds of Formula (I) which can be used as SGK inhibitors; pharmaceutical compositions comprising the compounds of the invention; as well as uses and methods for treating a disease mediated by SGK by administering the compounds of the invention.

Abstract: The present invention provides a novel EZH2 inhibitor compound represented by formula (I) and a use of the inhibitor compound in preventing or treating a disease mediated by EZH2.

Abstract: The disclosure relates to a decentralized cyber-physical system including a managing unit and a plurality of components. The managing unit includes a root resilient manager including a root contract and a sub-contract generator. The sub-contract generator is configured to decompose the root contract into a plurality of sub-contracts and assign the plurality of sub-contracts to the plurality of components, respectively. Each component includes at least one observer configured to monitor if the property of the individual component violates the sub-contracts corresponding thereto. When one of the plurality of sub-contracts violates during the runtime of the decentralized cyber-physical system, the root resilience manager issues an alarm.

Abstract: The invention provides novel chemical compounds useful for treating one or more of autoimmune diseases, cancer, cardiovascular diseases, inflammatory diseases and diabetes, or a related disease or disorder thereof, and pharmaceutical composition and methods of preparation and use thereof.

Abstract: Provided are small molecule inhibitors of ubiquitin specific protease 1 (USP1) activity and methods for their use in treating and characterizing cancers. The small molecule USP1 inhibitors of the invention are particularly useful in the treatment of cancers that are resistant to DNA cross-linking agents.

Abstract: An information processing method, a server, and a computer storage medium are provided. The method includes: generating a first information identification code according to first information, the first information representing an information source; providing the first information identification code to a terminal; receiving a first request from the terminal and allowing a terminal user of the terminal to follow an information service, the first request carrying the first information; and recording the first information and tracking and obtaining conversion information of the information source according to the first information.

Abstract: The present invention relates to a method using some novel compounds and compositions for the inhibition of ROS tyrosine kinase. In particular, the present invention covers a method to treat abnormal cell growth, such as cancer, with ROS 10 inhibitors and compositions having ROS inhibitors. An illustrative compound of the invention is shown below Formula (I).

Abstract: Provided are small molecule inhibitors of ubiquitin specific protease 1 (USP1) activity and methods for their use in treating and characterizing cancers. The small molecule USP1 inhibitors of the invention are particularly useful in the treatment of cancers that are resistant to DNA cross-linking agents.

Abstract: An electronic test equipment is adapted to test an electronic component. The electronic component has a circuit body and a plurality of connectors that are electrically connected to the circuit body. The electronic test equipment includes a metallic test seat and a plurality of spring probes. The metallic test seat is adapted to support the circuit body thereon, and is formed with a plurality of spaced-apart probe holes extending therethrough and possessing diameters that are substantially the same. Each of the probe holes is adapted to receive a corresponding one of the connectors. The spring probes are respectively and entirely positioned within the probe holes, and are adapted to electrically contact the connectors.

Abstract: This invention relates to compounds of Formulas I, II, and III, and their use as inhibitors of phosphatidylcholine transfer protein (PC-TP). The invention further relates to pharmaceutical compositions and methods of treatment of disorders related to the inhibition of PC-TP using the compounds of Formulas I, II, and III. Such disorders include obesity and disorders associated with obesity.

Abstract: Provided are small molecule inhibitors of ubiquitin specific protease 1 (USP1) activity and methods for their use in treating and characterizing cancers. The small molecule USP1 inhibitors of the invention are particularly useful in the treatment of cancers that are resistant to DNA cross-linking agents.

Abstract: The present invention relates to a method using some novel compounds and compositions for the inhibition of ROS tyrosine kinase. In particular, the present invention covers a method to treat abnormal cell growth, such as cancer, with ROS 10 inhibitors and compositions having ROS inhibitors. An illustrative compound of the invention is shown below Formula (I).

Abstract: This invention relates to compounds of Formulas I, II, and III, and their use as inhibitors of phosphatidylcholine transfer protein (PC-TP). The invention further relates to pharmaceutical compositions and methods of treatment of disorders related to the inhibition of PC-TP using the compounds of Formulas I, II, and III. Such disorders include obesity and disorders associated with obesity.

Abstract: This invention relates to compounds of Formulas I, II, and III, and their use as inhibitors of phosphatidylcholine transfer protein (PC-TP). The invention further relates to pharmaceutical compositions and methods of treatment of disorders related to the inhibition of PC-TP using the compounds of Formulas I, II, and III. Such disorders include obesity and disorders associated with obesity.

Abstract: A method predicts power flow in a distributed generation network of at least one distributed generator and at least one co-generator, where the network is defined by a plurality of network nonlinear equations. The method includes applying an iterative method to the plurality of network nonlinear equations to achieve a divergence from a power flow solution to the plurality of network nonlinear equations. The method also includes applying the iterative method to find a first solution to a plurality of simplified nonlinear equations homotopically related by parameterized power flow equations to the plurality of network nonlinear equations. The method further includes iteratively applying the iterative method to the parameterized power flow equations starting with the first solution to achieve the power flow solution to the plurality of network nonlinear equations.

Abstract: Provided are small molecule inhibitors of ubiquitin specific protease 1 (USP1) activity and methods for their use in treating and characterizing cancers. The small molecule USP1 inhibitors of the invention are particularly useful in the treatment of cancers that are resistant to DNA cross-linking agents.