Abstract: The present invention provides methods and compositions for treating cancer, reducing side effects, and reducing postmenopausal symptoms comprising anordrin or analog thereof (such as anordrin) alone or in combination with at least one other agent selected from the group consisting of tamoxifen, raloxifene or functional equivalent thereof, and an aromatase inhibitor.

Abstract: An inducible chimeric antigen receptor and its application relate to the field of immune therapy. The inducible antigen receptor includes a single-chain variable fragment (scFv) antibody against human CSF1R, a truncated hIgG1 hinge region SH, a T cell co-stimulatory signaling molecule, and a T cell cytoplasmic signaling domain. Transcription of the chimeric antigen receptor is regulated by an inducible expression element tet operator. The induce chimeric antigen receptor molecules can be used to modify T lymphocytes, eliminating the cytokine storm problem of CAR-T cells in the treatment of Alzheimer's disease (AD), and achieving target treatment of AD.

Abstract: A B7-H3 targeting antibody-drug conjugate, and a preparation method therefor and use thereof. Provided is the antibody-drug conjugate as shown in formula I. The compound has a good targeting property, good inhibitory effect on tumor cells positively expressing B7-H3, and good druggability and safety. The present antibody-drug conjugate has an inhibitory effect against B7-H3, and also a good inhibitory effect against at least one of NCI-N87, A375, LN-229, PA-1, MDA-MB-468, Calu-6 and HS-700T cells.

Abstract: A wireless communication method includes receiving, by a communication node, a first signal. The method further includes determining quasi co-location (QCL) information for the first signal based on at least one of a predefined rule and a configuration information from a base station, and performing a selective monitoring of a control channel based on information received in the first signal.

Abstract: A data processing method and apparatus. The data process method includes: determining, by a transmitting node, a code block length N0 for encoding an information bit sequence to be transmitted according to a data characteristic for representing the information bit sequence to be transmitted and a preset parameter corresponding to the data characteristic; performing, by the transmitting node, polar encoding on the information bit sequence to be transmitted according to the code block length N0; and transmitting, by the transmitting node, a code block obtained through the polar encoding to a receiving node.

Abstract: A TROP2 targeting antibody-drug conjugate, and a preparation method and use therefor. The antibody-drug conjugate is shown in formula I. Said type of compound has a good targeting property, a good inhibitory effect on tumor cells positively expressing TROP2, and good druggability and high safety. The present antibody drug conjugate has an inhibitory effect on TROP2, and also a good inhibitory effect on at least one of NCI-N87, MDA-MB-468 and BXPC3 cells.

Abstract: Provided is a genetically modified non-human animal, in which at least one copy of the endogenous nucleotide sequence encoding Protein C in the genome of said the non-human animal has been replaced by a nucleotide sequence encoding human Protein C or a functional fragment or variant thereof. Also provided are vectors, cells, and methods for the production of such non-human animals. Further provided are methods of testing agents for their ability to alter to the level and/or functional activity of human protein C, for example, to test their potential therapeutic efficacy.

Abstract: A low density parity check encoding method, including: determining a target parity check matrix, where the target parity check matrix belongs to a second parity check matrix set, and a base graph of the second parity check matrix set is extracted from a base graph of a first parity check matrix set and performing low density parity check encoding on data to be transmitted according to the target parity check matrix and a target lifting size.

Abstract: A modified silicon-carbon negative electrode material, a preparation method therefor, and an application thereof are disclosed. A method includes mixing a silicon-carbon negative electrode material with a lithium alkoxide solution to carry out a solvothermal reaction. The solid powder obtained after the solvothermal reaction is alcohol washed. The powder is dried to obtain the modified silicon-carbon negative electrode material. The lithium alkoxide solution is formed by mixing metallic lithium with an alcohol solvent.

Abstract: Method, systems and devices for identifying and mitigating remote interference, e.g. a downlink transmission from a remote network device interfering with uplink transmissions of another network device, are described. One example method for identifying remote interference includes determining that an interference type is a remote interference, and transmitting, in response to the determining, a reference signal indicative of a resource that was affected by the remote interference. Another example method for identifying remote interference includes detecting a reference signal in a frame, and determining a resource that was affected by a remote interference based on a position of the reference signal in the frame.

Abstract: Soft magnetic powder, a preparation method therefor, and a use thereof. The preparation method comprises: (1) respectively independently performing surface silane coupling and silicon nitriding treatment on first magnetic powder, second magnetic powder, and third magnetic powder to obtain first magnetic powder, second magnetic powder, and third magnetic powder of which the surfaces are coated with compound films of —Si—N— chemical bonds; and (2) mixing the first magnetic powder, the second magnetic powder, and the third magnetic powder of which the surfaces are coated with the compound films of the —Si—N— chemical bonds, so as to obtain the soft magnetic powder.

Abstract: A detection apparatus determines whether a recording layer of an optical disc is at a focal point of an objective lens. The detection apparatus includes an objective lens, a beam splitter, a reflector, a detector, and a servo controller. The reflector and the detector are disposed opposite to each other on two sides of an optical axis of the objective lens, and a normal line of the reflector is perpendicular to the optical axis. The beam splitter is disposed between the reflector and the detector and is located on the optical axis. The servo controller is connected to the detector.

Abstract: An integrated co-fired inductor and preparation method therefor, comprising: batch filling a magnetic powder in the mold cavity, embedding at least one wire into one layer of the magnetic powder, the two ends of the wire extending out of the mold cavity, sequentially performing compression molding and heat treatment to obtain a magnetic core, and bending and tinning the wire to obtain the co-fired inductor. The preparation method uses an integrated mold forming process to prepare the inductor to avoid an assembly process involving an excessive number of components; heat treatment is performed after the integral forming process, stress is fully released, material hysteresis loss is reduced, and the loss of the device under light load conditions is reduced; no extra gap exists between the wire and the magnetic core, air gaps are uniformly distributed within the magnetic core, and the vibration noise of eddy current loss is reduced.

Abstract: An antibody-drug conjugate, and an intermediate thereof, a preparation method therefor, and an application thereof. Provided is an antibody-drug conjugate as represented by formula I. The compound has good targetability, has a good inhibitory effect on HER3-positive tumor cells, and has good druggability and high safety. The antibody-drug conjugate has an inhibitory effect on HER3, has an inhibitory effect on SK-BR-3 and SW620 cells, and also has a good inhibitory effect on at least one of 22Rv1, LNCaP, NCI-H820, OVCAR-8, and HCC827 cells.

Abstract: The present invention provides a transformer, which is applied to the technical field of power transmission and distribution, the transformer comprising an iron core, body windings, and a semi-conductive layer, the body windings being sleeved on a core post of the iron core, and the semi-conductive layer being correspondingly provided with the body windings. Auxiliary circuits are connected to the body windings, the auxiliary circuits and preset positions of the body windings have equal potentials, and an equipotential connection point of the semi-conductive layer is provided by the auxiliary circuits. After the semi-conductive layer is connected to the auxiliary circuits, the effect of balancing the electric field distribution of a winding can be achieved.

Abstract: This disclosure above describes a method and system for transmitting and receiving Wake Up Burst and reducing UE power consumption. The method includes transmitting a Wake Up Burst (WUB) to a User Equipment (UE), the WUB comprising a reference signal. The disclosure describes format and functionality of the WUB, as well as various scheme for allocating resource for the WUB.

Abstract: An integrated co-fired inductor and preparation method therefor, comprising: filling a mold cavity with a magnetic powder, embedding at least one wire in the magnetic powder, wherein the two ends extend out of the mold cavity, sequentially performing compression molding and heat treatment to obtain a magnetic core, and bending and tinning the wire extending out of the magnetic core to obtain the co-fired inductor. The preparation method uses an integrated mold forming process to prepare the inductor to avoid an assembly process involving an excessive number of components; heat treatment is performed after the integral forming process, stress is fully released, material hysteresis loss is reduced, and the loss of the device under light load conditions is reduced; no extra gap exists between the wire and the magnetic core, air gaps are uniformly distributed within the magnetic core, and the vibration noise of eddy current loss is reduced.

Abstract: A pet litter box and a control method of a pet litter box are provided. The pet litter box includes: a base and a box body, where the base is provided with a chamber; a top side of the base is provided with a base opening; the box body is provided in the chamber; and the base includes a shell bottom opposite to the base opening and a shell wall provided in a peripheral direction of the shell bottom.

Abstract: Provided is a bridge cascade system, which includes at least one phase unit and a driving unit for the phase unit. The phase unit includes N bridge topologies cascaded on alternating current AC sides. The driving unit includes one driving power supply circuit, multiple bootstrap power supply circuits and 2N driving circuits. In the phase unit, the driving circuits are powered by the driving power supply circuit directly or through corresponding bootstrap power supply circuits. The driving circuits are configured to provide driving signals for corresponding switch transistors in the phase unit. In this way, one driving power supply is matched with multiple bootstrap power supply circuits, realizing power supply to the driving circuits corresponding to the switch transistors of all bridge topologies, which reduces the difficulty in designing the driving power supply for the bridge cascade system and reduces cost for the system.

Abstract: A programming pulse is caused to be applied to a wordline associated with a memory cell of the memory sub-system. A program verify operation is caused to be performed on the memory cell to determine that a measured threshold voltage associated with the memory cell. The measured threshold voltage associated with the memory cell is stored in a sensing node associated with the memory cell. A bitline voltage matching the measured threshold voltage is caused to be applied to a bitline associated with the memory cell to reduce a rate of programming associated with the memory cell.