Abstract: Non-human animal cells and non-human animals comprising a humanized Tfrc gene, e.g., at an endogenous Tfrc locus, and methods of using such non-human animal cells and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized Tfrc gene express a human TfR protein or fragments thereof. Non-human animal cells and non-human animals comprising a humanized Tfrc gene and a knockout mutation in a Gaa gene, e.g., at an endogenous Gaa locus, and methods of using such non-human animal cells and non-human animals are also provided. Such animals are useful to screen anti-human-TfR binding protein based therapies of, e.g., Pompe disease.

Abstract: The present disclosure relates to a method for analyzing a geological body with the help of physical and chemical properties thereof, and in particular, to a method for identifying an exudative sandstone uranium deposit. With the method for identifying an exudative sandstone uranium deposit according to the embodiments of the present disclosure, an exudative sandstone uranium deposit formed by an exudation metallogenesis may be systematically identified, so as to guide prediction and prospecting evaluation of a uranium deposit in red variegated sandstone formations of a sedimentary basin, avoid ore dislocation and ore leakage, open up new prospecting positions and spaces, and break through new uranium resources.

Abstract: A control method for a lighting system, a lighting system, and a storage medium are provided. The method includes steps of receiving a control instruction for the electric bracket, acquiring accessory information of the accessory based on the control instruction, determining control parameters of the electric bracket which are configured for the lighting device, based on the accessory information, and calibrating the electric bracket based on the control parameters.

Abstract: A nitrogen-containing polycyclic fused ring compound of formula I, a pharmaceutical composition thereof, a preparation method therefor and use thereof are related to the field of medicinal chemistry. The compound can be used as a selective and effective RET inhibitor. It has strong inhibitory effect on the RET gatekeeper residue mutant RET V804M, RET solvent-front residue mutant RET G810R and other clinically relevant RET mutants, as well as RET wt. The compound can also inhibit the growth of TT cell line derived from thyroid cancer and Ba/F3 cells transformed with various RET mutants, and induce the death of TT cells.

Abstract: Provided are a method for determining a fault in a position signal of a motor, a device, a system, and a vehicle. According to embodiments of the present disclosure, the method for determining the fault in the position signal of the motor includes: acquiring an electrical signal outputted by a position sensor, the position sensor being configured to acquire an angle of the motor; calculating a first angle of the motor based on the electrical signal by using a first algorithm; calculating a second angle of the motor based on the electrical signal by using a second algorithm, and in response to a difference between the first angle and the second angle being smaller than or equal to a predetermined value, determining that there is a fault in the position signal of the motor.

Abstract: A method for preparing a nitrogen-containing polycyclic fused ring compound of formula I, and an intermediate thereof are provided. By this method, the compound of formula I can be produced on an industrial scale without column chromatography separation, purification steps such as silica gel column chromatography, or hydrogen. In addition, the preparation method effectively uses positional isomers IIIA and IIIB, and improves the yield of a target product from being adversely influenced by discarding positional isomer IIIA.

Abstract: A variable-stroke self-adaptive adjustment quasi-zero stiffness device includes an integrating sphere, a target, a collimator, a pointing measuring instrument, a disturbance source, an inertia simulation tooling, a quasi-zero stiffness suspension adjustment device and an optical air-bearing platform. The integrating sphere, the target and the collimator are coaxially mounted on the optical air-bearing platform in sequence. The pointing measuring instrument is connected and fixed with the inertia simulation tooling through a screw; three disturbance sources are mounted on the inertia simulation tooling to provide small disturbance and inertia for the pointing measuring instrument; the quasi-zero stiffness suspension adjustment device suspends the inertia simulation tooling to provide a free boundary environment; and the quasi-zero stiffness suspension adjustment device, the pointing measuring instrument, the disturbance source and the inertia simulation tooling form a set of two-pendulum system as a whole.

Abstract: The present disclosure relates to a method for analyzing a geological body with the help of physical and chemical properties thereof, and in particular, to a method for identifying an exudative sandstone uranium deposit. With the method for identifying an exudative sandstone uranium deposit according to the embodiments of the present disclosure, an exudative sandstone uranium deposit formed by an exudation metallogenesis may be systematically identified, so as to guide prediction and prospecting evaluation of a uranium deposit in red variegated sandstone formations of a sedimentary basin, avoid ore dislocation and ore leakage, open up new prospecting positions and spaces, and break through new uranium resources.

Abstract: A device and a method for determining a microvibration effect on a millisecond-level space optical sensor are provided. The device includes: a light source, a star simulator, an air flotation vibration isolation platform, a suspension system/air flotation system, a zero stiffness system, a supporting system, a six-degree-of-freedom microvibration simulator, a signal driving apparatus, and a data acquisition and processing system. In the device for determining a microvibration effect on a space pointing measurement apparatus, a free boundary condition and a zero gravity environment are simulated by using a suspension system and a zero stiffness system. A light source and a star simulator simulate a star at infinity. A six-degree-of-freedom microvibration simulator simulates an on-orbit microvibration mechanical environment which is used as an input of a test. Extremely high-precision sensors collect system response data.

Abstract: A nitrogen-containing polycyclic fused ring compound represented by formula I, a pharmaceutical composition thereof, a preparation method therefor, and a use thereof are provided. The compound has an inhibitory effect on RET gatekeeper residue mutant RET V804M mutation, RET solvent front residue mutant G810R, and other clinically relevant RET mutants and RET-wt. The compound can also significantly inhibit the growth of a TT cell line derived from thyroid cancer and Ba/F3 cells transformed by various RET mutants, and has a stronger inhibition effect than selective RET inhibitor LOXO-292. In addition, the compound can block cellular RET autophosphorylation and downstream pathways, and can significantly induce TT cell death.

Abstract: A device and a method for determining a microvibration effect on a millisecond-level space optical sensor are provided. The device includes: a light source, a star simulator, an air flotation vibration isolation platform, a suspension system/air flotation system, a zero stiffness system, a supporting system, a six-degree-of-freedom microvibration simulator, a signal driving apparatus, and a data acquisition and processing system. In the device for determining a microvibration effect on a space pointing measurement apparatus, a free boundary condition and a zero gravity environment are simulated by using a suspension system and a zero stiffness system. A light source and a star simulator simulate a star at infinity. A six-degree-of-freedom microvibration simulator simulates an on-orbit microvibration mechanical environment which is used as an input of a test. Extremely high-precision sensors collect system response data.

Abstract: A nitrogen-containing polycyclic fused ring compound of formula I, a pharmaceutical composition thereof, a preparation method therefor and use thereof are related to the field of medicinal chemistry. The compound can be used as a selective and effective RET inhibitor. It has strong inhibitory effect on the RET gatekeeper residue mutant RET V804M, RET solvent-front residue mutant RET G810R and other clinically relevant RET mutants, as well as RET wt. The compound can also inhibit the growth of TT cell line derived from thyroid cancer and Ba/F3 cells transformed with various RET mutants, and induce the death of TT cells.

Abstract: A compound is represented by the following formula I. The compound and stereoisomer, racemate, tautomer, isotope labelled derivative, nitrogen oxide, pharmaceutically acceptable salt or solvate thereof can be prepared and used in the preparation of a medicament for treating a RET kinase-mediated disease.

Abstract: The present invention relates to a S-substituted-2-amino-3-mercaptopropionate derivative, a preparation method and an application thereof. The S-substituted-2-amino-3-mercaptopropionate derivative in the present invention has a structure of a formula (A). The present invention also includes an application of the S-substituted-2-amino-3-mercaptopropionate derivative serving as a medicine for treating and/or preventing neurodegenerative diseases, particularly Alzheimer's disease.

Abstract: The present invention discloses deuterated thienopiperidine derivatives, a manufacturing method and an application thereof. The deuterated thienopiperidine derivatives in the present invention are of a structure of the following formula (I). The present invention also comprises the application of the deuterated thienopiperidine derivatives as a drug for treating and preventing cardiovascular and cerebrovascular diseases.

Abstract: The present invention relates to a kind of thienopiperidine derivative or pharmaceutically acceptable acid addition salt thereof and a pharmaceutical composition comprising these compounds, the thienopiperidine derivative related in the present invention has a structure as represented by formula (I): In formula (I), represents —O—R or ?O; X is P or S, m is 0 or 1, R, R? can be the same or different, respectively and independently are H, C1-C4 braight or branched alkyl substituted by halogen or unsubstituted, phenyl or substituted phenyl. The present invention also relates to the uses of the described thienopiperidine derivative in preparing drugs for preventing platelet aggregation and for treating or preventing cardiovascular and cerebrovascular diseases.

Abstract: The present invention relates to a S-substituted-2-amino-3-mercaptopropionate derivative, a preparation method and an application thereof. The S-substituted-2-amino-3-mercaptopropionate derivative in the present invention has a structure of a formula (A). The present invention also includes an application of the S-substituted-2-amino-3-mercaptopropionate derivative serving as a medicine for treating and/or preventing neurodegenerative diseases, particularly Alzheimer's disease.

Abstract: The present invention discloses deuterated thienopiperidine derivatives, a manufacturing method and an application thereof. The deuterated thienopiperidine derivatives in the present invention are of a structure of the following formula (I). The present invention also comprises the application of the deuterated thienopiperidine derivatives as a drug for treating and preventing cardiovascular and cerebrovascular diseases.

Abstract: The present invention relates to a kind of thienopiperidine derivative or pharmaceutically acceptable acid addition salt thereof and a pharmaceutical composition comprising these compounds, the thienopiperidine derivative related in the present invention has a structure as represented by formula(I): In formula (I) represents —O—R or ?O; X is P or S, m is 0 or 1, R, R? can be the same or different, respectively and independently are H, C1-C4 braight or branched alkyl substituted by halogen or unsubstituted, phenyl or substituted phenyl. The present invention also relates to the uses of the described thienopiperidine derivative in preparing drugs for preventing platelet aggregation and for treating or preventing cardiovascular and cerebrovascular diseases.

Abstract: The invention discloses a background service process unit, a position system and a method for call control thereof. The method includes: a browser sending an operation request according to a customer representative to a background service process unit through an operation page; the background service process unit judging whether the operation can be performed currently, if yes, sending the operation request to a CTI server; the CTI server forwarding the received operation request to an automatic call distributor for performing, and forwarding an operation completion notification message, after the operation request is performed completely, to the background service process unit; the background service process unit making a switching to a position state according to the operation completion notification message.