Patents by Inventor Jundong Meng

Jundong Meng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • A HIGH-PURITY ADRENOCORTICOTROPIC HORMONE ANALOGUE AND A LARGE-SCALE PREPARATION METHOD THEREOF
    Publication number: 20220401521
    Abstract: The invention belongs to the technical field of polypeptide preparation methods, and in particular relates to a high-purity ACTH (human sequence) or analogue and large-scale preparation method thereof. The main steps include: amino acids are coupled from the C-terminal to the N-terminal by Fmoc solid-phase synthesis method to obtain the crude ACTH (human sequence) or analogue peptidyl-resin with protective groups, wherein the reaction temperature of C-15 peptide synthesis is 40-60° C. After cleavage and precipitation, the crude product of ACTH (human sequence) or analogue is obtained, and then the high-purity product is obtained by liquid chromatography. The chromatographic purity of ACTH (human sequence) or analogue prepared by the invention is more than 99%, the stability is good, and the yield of the target peptide is ?63%.
    Type: Application
    Filed: August 19, 2022
    Publication date: December 22, 2022
    Inventors: Jundong Meng, Tao Yang, Feifei Wu, Haoning Zhang
  • High-purity adrenocorticotropic hormone, analogue and a large-scale preparation method thereof
    Patent number: 11419919
    Abstract: The invention belongs to the technical field of polypeptide preparation methods, and in particular relates to a high-purity ACTH (human sequence) or analogue and large-scale preparation method thereof. The main steps include: amino acids are coupled from the C-terminal to the N-terminal by Fmoc solid-phase synthesis method to obtain the crude ACTH (human sequence) or analogue peptidyl-resin with protective groups, wherein the reaction temperature of C-15 peptide synthesis is 40-60° C. After cleavge and precipitation, the crude product of ACTH (human sequence) or analogue is obtained, and then the high-purity product is obtained by liquid chromatography. The chromatographic purity of ACTH (human sequence) or analogue prepared by the invention is more than 99%, the stability is good, and the yield of the target peptide is ?63%.
    Type: Grant
    Filed: June 24, 2021
    Date of Patent: August 23, 2022
    Assignee: Nanjing Hanxin Pharmaceutical Technology Co., Ltd.
    Inventors: Jundong Meng, Kangning Rui, Bin Liu, Yuanyuan Han, Song Chen, Haoning Zhang
  • Method of purifying idraparinux sodium
    Patent number: 9873712
    Abstract: A method for the purification of idraparinux sodium includes: passing a solution including a crude idraparinux sodium through a column including a sodium ion exchange resin to obtain a first mixture; passing a solution including the first mixture through a gel chromatogaphy column to obtain a second mixture; and precipitating a purified idraparinux sodium from a solution including the second mixture.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: January 23, 2018
    Assignee: Amphastar Pharmaceuticals, Inc.
    Inventors: Jundong Meng, Yonggang Xu, Wencun Wang, Song Chen, Haoning Zhang
  • METHOD OF PURIFYING IDRAPARINUX SODIUM
    Publication number: 20160096856
    Abstract: A method for the purification of idraparinux sodium includes: passing a solution including a crude idraparinux sodium through a column including a sodium ion exchange resin to obtain a first mixture; passing a solution including the first mixture through a gel chromatogaphy column to obtain a second mixture; and precipitating a purified idraparinux sodium from a solution including the second mixture.
    Type: Application
    Filed: May 15, 2015
    Publication date: April 7, 2016
    Inventors: Jundong Meng, Yonggang Xu, Wencun Wang, Song Chen, Haoning Wang